FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321487204> ?p ?o ?g. }

• W4321487204 abstract "Liver fibrosis is a life-threatening pathological anomaly which usually evolves into advanced liver cirrhosis and hepatocellular carcinoma although limited therapeutic option is readily available. FUN14 domain containing 1 (FUNDC1) is a mitophagy receptor with little information in liver fibrosis.This study was designed to examine the role for FUNDC1 in carbon tetrachloride (CCl4)-induced liver injury.GEO database analysis and subsequent validation of biological processes including western blot, immunofluorescence, and co-immunoprecipitation were applied to clarify the regulatory role of FUNDC1 on mitophagy and ferroptosis.Our data revealed elevated FUNDC1 levels in liver tissues of patients with liver fibrotic injury and CCl4-challenged mice. FUNDC1 deletion protected against CCl4-induced hepatic anomalies in mice. Moreover, FUNDC1 deletion ameliorated CCl4-induced ferroptosis in vivo and in vitro. Mechanically, FUNDC1 interacted with glutathione peroxidase (GPx4), a selenoenzyme to neutralize lipid hydroperoxides and ferroptosis, via its 96-133 amino acid domain to facilitate GPx4 recruitment into mitochondria from cytoplasm. GPx4 entered mitochondria through mitochondrial protein import system-the translocase of outer membrane/translocase of inner membrane (TOM/TIM) complex, prior to degradation of GPx4 mainly through mitophagy along with ROS-induced damaged mitochondria, resulting in hepatocyte ferroptosis.Taken together, our data favored that FUNDC1 promoted hepatocyte injury through GPx4 binding to facilitate its mitochondrial translocation through TOM/TIM complex, where GPx4 was degraded by mitophagy to trigger ferroptosis. Targeting FUNDC1 may be a promising therapeutic approach for liver fibrosis." @default.
• W4321487204 created "2023-02-23" @default.
• W4321487204 creator A5008568216 @default.
• W4321487204 creator A5018072765 @default.
• W4321487204 creator A5029484872 @default.
• W4321487204 creator A5033201492 @default.
• W4321487204 creator A5036965952 @default.
• W4321487204 creator A5047987427 @default.
• W4321487204 creator A5055794211 @default.
• W4321487204 creator A5055875257 @default.
• W4321487204 creator A5065560361 @default.
• W4321487204 creator A5066289448 @default.
• W4321487204 creator A5090257502 @default.
• W4321487204 date "2023-02-01" @default.
• W4321487204 modified "2023-10-15" @default.
• W4321487204 title "FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner" @default.
• W4321487204 cites W1919254267 @default.
• W4321487204 cites W1992033043 @default.
• W4321487204 cites W1997183854 @default.
• W4321487204 cites W2002490399 @default.
• W4321487204 cites W2011052121 @default.
• W4321487204 cites W2033231579 @default.
• W4321487204 cites W2058799578 @default.
• W4321487204 cites W2067107606 @default.
• W4321487204 cites W2069386166 @default.
• W4321487204 cites W2085224193 @default.
• W4321487204 cites W2146122852 @default.
• W4321487204 cites W2276179096 @default.
• W4321487204 cites W2345721849 @default.
• W4321487204 cites W2522446227 @default.
• W4321487204 cites W2579276161 @default.
• W4321487204 cites W2601166832 @default.
• W4321487204 cites W2800668750 @default.
• W4321487204 cites W2800885070 @default.
• W4321487204 cites W2804020656 @default.
• W4321487204 cites W2884556905 @default.
• W4321487204 cites W2884686428 @default.
• W4321487204 cites W2901573161 @default.
• W4321487204 cites W2906319220 @default.
• W4321487204 cites W2907246363 @default.
• W4321487204 cites W2914436528 @default.
• W4321487204 cites W2933550566 @default.
• W4321487204 cites W2942140770 @default.
• W4321487204 cites W2978816214 @default.
• W4321487204 cites W2979641493 @default.
• W4321487204 cites W2980472864 @default.
• W4321487204 cites W2984537832 @default.
• W4321487204 cites W2985065511 @default.
• W4321487204 cites W2988889252 @default.
• W4321487204 cites W2994550619 @default.
• W4321487204 cites W2997148129 @default.
• W4321487204 cites W3002823891 @default.
• W4321487204 cites W3010348275 @default.
• W4321487204 cites W3013293439 @default.
• W4321487204 cites W3021818653 @default.
• W4321487204 cites W3033074721 @default.
• W4321487204 cites W3045446009 @default.
• W4321487204 cites W3087013454 @default.
• W4321487204 cites W3091332987 @default.
• W4321487204 cites W3095376832 @default.
• W4321487204 cites W3106791130 @default.
• W4321487204 cites W3129972903 @default.
• W4321487204 cites W3133823534 @default.
• W4321487204 cites W3135213615 @default.
• W4321487204 cites W3162516608 @default.
• W4321487204 cites W3177355887 @default.
• W4321487204 cites W3182929688 @default.
• W4321487204 doi "https://doi.org/10.1016/j.jare.2023.02.012" @default.
• W4321487204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36828120" @default.
• W4321487204 hasPublicationYear "2023" @default.
• W4321487204 type Work @default.
• W4321487204 citedByCount "4" @default.
• W4321487204 countsByYear W43214872042023 @default.
• W4321487204 crossrefType "journal-article" @default.
• W4321487204 hasAuthorship W4321487204A5008568216 @default.
• W4321487204 hasAuthorship W4321487204A5018072765 @default.
• W4321487204 hasAuthorship W4321487204A5029484872 @default.
• W4321487204 hasAuthorship W4321487204A5033201492 @default.
• W4321487204 hasAuthorship W4321487204A5036965952 @default.
• W4321487204 hasAuthorship W4321487204A5047987427 @default.
• W4321487204 hasAuthorship W4321487204A5055794211 @default.
• W4321487204 hasAuthorship W4321487204A5055875257 @default.
• W4321487204 hasAuthorship W4321487204A5065560361 @default.
• W4321487204 hasAuthorship W4321487204A5066289448 @default.
• W4321487204 hasAuthorship W4321487204A5090257502 @default.
• W4321487204 hasBestOaLocation W43214872041 @default.
• W4321487204 hasConcept C134018914 @default.
• W4321487204 hasConcept C158086472 @default.
• W4321487204 hasConcept C185592680 @default.
• W4321487204 hasConcept C190283241 @default.
• W4321487204 hasConcept C202751555 @default.
• W4321487204 hasConcept C203522944 @default.
• W4321487204 hasConcept C2776151105 @default.
• W4321487204 hasConcept C2776200302 @default.
• W4321487204 hasConcept C2776637226 @default.
• W4321487204 hasConcept C2778760513 @default.
• W4321487204 hasConcept C2778979269 @default.
• W4321487204 hasConcept C2779324830 @default.
• W4321487204 hasConcept C28859421 @default.
• W4321487204 hasConcept C502942594 @default.

• next