Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321491595> ?p ?o ?g. }
- W4321491595 abstract "Abstract Background Atopic dermatitis (AD) is a chronic, recurrent, itchy skin disease characterized by inflammatory imbalance. Objective To identify novel diagnostic biomarkers and potential therapeutic targets for AD. Methods Two test microarray datasets (GSE63741, GSE60709) and a validated dataset (GSE75890) were downloaded from the Gene Expression Omnibus database. We explored the hub genes by analysis of immune coexpression and protein–protein interaction. We also constructed a competing endogenous RNA (ceRNA) network to explore the new therapeutic targets. We estimated immune cell types by ImmucellAI and the relevance between hub genes and immune cells. Functional analysis was also performed. Finally, we validated the hub genes through real-time quantitative PCR (RT-qPCR), immunohistochemistry (IHC) and western blotting (WB). Results A significantly altered proportion of 24 immune-cell types was found between healthy controls (HCs) and AD patients, and each of the hub genes was significantly correlated with the main infiltrating cells. Expression of S100A7 , APOE and KRT15 in skin tissues differed significantly between AD patients and HCs. hsa-miR-365a-3p and NPSR1-AS1 were identified as potential new therapeutic targets of AD. Conclusion S100A7 , APOE and KRT15 were associated with immune cells and could become new diagnostic biomarkers and hsa-miR-365a-3p and NPSR1-AS1 might be new therapeutic targets of AD." @default.
- W4321491595 created "2023-02-23" @default.
- W4321491595 creator A5017216785 @default.
- W4321491595 creator A5018898266 @default.
- W4321491595 creator A5021833618 @default.
- W4321491595 creator A5049075415 @default.
- W4321491595 creator A5052646625 @default.
- W4321491595 creator A5053413262 @default.
- W4321491595 creator A5053838397 @default.
- W4321491595 creator A5058380236 @default.
- W4321491595 creator A5069170273 @default.
- W4321491595 date "2023-02-22" @default.
- W4321491595 modified "2023-09-25" @default.
- W4321491595 title "Identifying immune cell infiltration and constructing a ceRNA network to explore novel diagnostic biomarkers and therapeutic targets in atopic dermatitis" @default.
- W4321491595 cites W1201924020 @default.
- W4321491595 cites W1960770201 @default.
- W4321491595 cites W1965007203 @default.
- W4321491595 cites W1979686755 @default.
- W4321491595 cites W1995552142 @default.
- W4321491595 cites W2002600662 @default.
- W4321491595 cites W2017777108 @default.
- W4321491595 cites W2020541351 @default.
- W4321491595 cites W2025346638 @default.
- W4321491595 cites W2028176002 @default.
- W4321491595 cites W2028372028 @default.
- W4321491595 cites W2035944097 @default.
- W4321491595 cites W2057450814 @default.
- W4321491595 cites W2061503084 @default.
- W4321491595 cites W2077180647 @default.
- W4321491595 cites W2083381199 @default.
- W4321491595 cites W2085938864 @default.
- W4321491595 cites W2088552013 @default.
- W4321491595 cites W2103912979 @default.
- W4321491595 cites W2117977572 @default.
- W4321491595 cites W2118258530 @default.
- W4321491595 cites W2123250471 @default.
- W4321491595 cites W2158042884 @default.
- W4321491595 cites W2159346740 @default.
- W4321491595 cites W2159675211 @default.
- W4321491595 cites W2171398108 @default.
- W4321491595 cites W2177198880 @default.
- W4321491595 cites W2179886188 @default.
- W4321491595 cites W2325147761 @default.
- W4321491595 cites W2336229378 @default.
- W4321491595 cites W2339134557 @default.
- W4321491595 cites W2395328824 @default.
- W4321491595 cites W2399280193 @default.
- W4321491595 cites W2411361269 @default.
- W4321491595 cites W2537623931 @default.
- W4321491595 cites W2565686633 @default.
- W4321491595 cites W2605235260 @default.
- W4321491595 cites W2611663587 @default.
- W4321491595 cites W2765905017 @default.
- W4321491595 cites W2767694090 @default.
- W4321491595 cites W2789232815 @default.
- W4321491595 cites W3005889306 @default.
- W4321491595 cites W3029717128 @default.
- W4321491595 cites W3084361883 @default.
- W4321491595 cites W3199424339 @default.
- W4321491595 cites W4211026773 @default.
- W4321491595 cites W4211145137 @default.
- W4321491595 cites W4211146151 @default.
- W4321491595 doi "https://doi.org/10.21203/rs.3.rs-2589492/v1" @default.
- W4321491595 hasPublicationYear "2023" @default.
- W4321491595 type Work @default.
- W4321491595 citedByCount "0" @default.
- W4321491595 crossrefType "posted-content" @default.
- W4321491595 hasAuthorship W4321491595A5017216785 @default.
- W4321491595 hasAuthorship W4321491595A5018898266 @default.
- W4321491595 hasAuthorship W4321491595A5021833618 @default.
- W4321491595 hasAuthorship W4321491595A5049075415 @default.
- W4321491595 hasAuthorship W4321491595A5052646625 @default.
- W4321491595 hasAuthorship W4321491595A5053413262 @default.
- W4321491595 hasAuthorship W4321491595A5053838397 @default.
- W4321491595 hasAuthorship W4321491595A5058380236 @default.
- W4321491595 hasAuthorship W4321491595A5069170273 @default.
- W4321491595 hasBestOaLocation W43214915951 @default.
- W4321491595 hasConcept C104317684 @default.
- W4321491595 hasConcept C126322002 @default.
- W4321491595 hasConcept C150194340 @default.
- W4321491595 hasConcept C186836561 @default.
- W4321491595 hasConcept C203014093 @default.
- W4321491595 hasConcept C2778329239 @default.
- W4321491595 hasConcept C2779134260 @default.
- W4321491595 hasConcept C54355233 @default.
- W4321491595 hasConcept C60365752 @default.
- W4321491595 hasConcept C62203573 @default.
- W4321491595 hasConcept C67705224 @default.
- W4321491595 hasConcept C71924100 @default.
- W4321491595 hasConcept C86803240 @default.
- W4321491595 hasConcept C8891405 @default.
- W4321491595 hasConceptScore W4321491595C104317684 @default.
- W4321491595 hasConceptScore W4321491595C126322002 @default.
- W4321491595 hasConceptScore W4321491595C150194340 @default.
- W4321491595 hasConceptScore W4321491595C186836561 @default.
- W4321491595 hasConceptScore W4321491595C203014093 @default.
- W4321491595 hasConceptScore W4321491595C2778329239 @default.
- W4321491595 hasConceptScore W4321491595C2779134260 @default.
- W4321491595 hasConceptScore W4321491595C54355233 @default.
- W4321491595 hasConceptScore W4321491595C60365752 @default.