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• W4321495478 abstract "On 2/2019, the Neonatal Antimicrobial Stewardship Program at Nationwide Children’s Hospital recommended reducing empirical antibiotic therapy for early-onset sepsis (EOS) from 48 to 24 hours with a TIME-OUT. We describe our experience with this guideline and assess its safety. Retrospective review of newborns evaluated for possible EOS at 6 NICUs from 12/2018-7/2019. Safety endpoints were re-initiation of antibiotics within 7 days after discontinuation of the initial course, positive bacterial blood or cerebrospinal fluid culture in the 7 days after antibiotic discontinuation, and overall and sepsis-related mortality. Among 414 newborns evaluated for EOS, 196 (47%) received a 24 hour rule-out sepsis antibiotic course while 218 (53%) were managed with a 48 hour course. The 24-hour rule-out group were less likely to have antibiotics re-initiated and did not differ in the other predefined safety endpoints. Antibiotic therapy for suspected EOS may be discontinued safely within 24 hours." @default.
• W4321495478 created "2023-02-23" @default.
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• W4321495478 date "2023-02-22" @default.
• W4321495478 modified "2023-10-15" @default.
• W4321495478 title "Short-course empiric antibiotic therapy for possible early-onset sepsis in the NICU" @default.
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• W4321495478 doi "https://doi.org/10.1038/s41372-023-01634-3" @default.
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