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• W4321496657 endingPage "119" @default.
• W4321496657 startingPage "119" @default.
• W4321496657 abstract "Light-cured composite resins are widely used in dental restorations to fill cavities and fabricate temporary crowns. After curing, the residual monomer is a known to be cytotoxic, but increasing the curing time should improve biocompatibility. However, a biologically optimized cure time has not been determined through systematic experimentation. The objective of this study was to examine the behavior and function of human gingival fibroblasts cultured with flowable and bulk-fill composites cured for different periods of time, while considering the physical location of the cells with regard to the materials. Biological effects were separately evaluated for cells in direct contact with, and in close proximity to, the two composite materials. Curing time varied from the recommended 20 s to 40, 60, and 80 s. Pre-cured, milled-acrylic resin was used as a control. No cell survived and attached to or around the flowable composite, regardless of curing time. Some cells survived and attached close to (but not on) the bulk-fill composite, with survival increasing with a longer curing time, albeit to <20% of the numbers growing on milled acrylic even after 80 s of curing. A few cells (<5% of milled acrylic) survived and attached around the flowable composite after removal of the surface layer, but attachment was not cure-time dependent. Removing the surface layer increased cell survival and attachment around the bulk-fill composite after a 20-s cure, but survival was reduced after an 80-s cure. Dental-composite materials are lethal to contacting fibroblasts, regardless of curing time. However, longer curing times mitigated material cytotoxicity exclusively for bulk-fill composites when the cells were not in direct contact. Removing the surface layer slightly improved biocompatibility for cells in proximity to the materials, but not in proportion to cure time. In conclusion, mitigating the cytotoxicity of composite materials by increasing cure time is conditional on the physical location of cells, the type of material, and the finish of the surface layer. This study provides valuable information for clinical decision making and novel insights into the polymerization behavior of composite materials." @default.
• W4321496657 created "2023-02-23" @default.
• W4321496657 creator A5003618989 @default.
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• W4321496657 date "2023-02-22" @default.
• W4321496657 modified "2023-10-18" @default.
• W4321496657 title "Conditional Mitigation of Dental-Composite Material-Induced Cytotoxicity by Increasing the Cure Time" @default.
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• W4321496657 doi "https://doi.org/10.3390/jfb14030119" @default.
• W4321496657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36976043" @default.
• W4321496657 hasPublicationYear "2023" @default.
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