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- W4321497130 abstract "摘要 CRISPR-Cas系统是细菌和古菌针对外源性可移动基因元件的一种适应性免疫系统. 为了逃避这种免疫效应，噬菌体可以通过表达Anti-CRISPR（Acr）蛋白以抑制CRISPR-Cas系统的作用. 通过生物信息学和生物化学的多种方法，人们至今已发现了三十二种针对II型CRISPR-Cas系统的Acr基因，其编码蛋白抑制CRISPR-Cas系统的机制不尽相同，可以抑制Cas蛋白从单体形式至催化反应完成全过程中的不同阶段，并且由于其对不同Cas蛋白的抑制能力，Acr蛋白有望应用于多种临床应用中成为重要的调控元件" @default.
- W4321497130 created "2023-02-23" @default.
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- W4321497130 date "2023-01-01" @default.
- W4321497130 modified "2023-09-28" @default.
- W4321497130 title "针对II型CRISPR-Cas系统的Acr基因的发现及Acr蛋白多样化的抑制机制" @default.
- W4321497130 doi "https://doi.org/10.1360/ssv-2022-0309" @default.
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