FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321497624> ?p ?o ?g. }

• W4321497624 abstract "Background: Major depression is one of the most common psychiatric disorders worldwide, inflicting suffering, significant reduction in life span, and financial burdens on families and society. Mounting evidence implicates that exposure to chronic stress can induce the dysregulation of the immune system, and the activation of brain-resident innate immune cells, microglia, leading to depression-like symptoms. However, the specific mechanisms need to be further elucidated. Method: Animal models of depression were established by chronic restraint stress (CRS), and depression-like behavior was assessed by sucrose preference test (SPT), open field test (OFT), tail suspension test (TST) and forced swimming test (FST). Microglial activation was visualized by immunofluorescent and immunohistochemical staining, and microglial morphological changes were further analyzed by skeleton analysis. The levels of inflammatory cytokines were detected by western blotting and qPCR. Result: Microglial Dlg1 knockout ameliorates CRS-induced mice depression-like behavior. In contrast to the effect of Dlg1 in the LPS-induced mouse model, Dlg1 knockout had little effect on microglial density, but significantly decreased the number of activated microglia and reversed microglia morphological changes in mice challenged with CRS. Moreover, the upregulation of inflammatory cytokines following CRS exposure was partially reversed by Dlg1 deletion. Conclusion: Our study provides the evidence that Dlg1 ablation in microglia remarkedly reverses microglial activation and depression-like behavior in mice exposed to CRS, implicating a potential target for the treatment of clinical depression." @default.
• W4321497624 created "2023-02-23" @default.
• W4321497624 creator A5026376619 @default.
• W4321497624 creator A5026731357 @default.
• W4321497624 creator A5050174686 @default.
• W4321497624 creator A5055151897 @default.
• W4321497624 creator A5059328163 @default.
• W4321497624 creator A5066862028 @default.
• W4321497624 creator A5081491205 @default.
• W4321497624 date "2023-02-22" @default.
• W4321497624 modified "2023-10-14" @default.
• W4321497624 title "Dlg1 deletion in microglia ameliorates chronic restraint stress induced mice depression-like behavior" @default.
• W4321497624 cites W1966654065 @default.
• W4321497624 cites W1967267265 @default.
• W4321497624 cites W1968764187 @default.
• W4321497624 cites W1985438873 @default.
• W4321497624 cites W1996454121 @default.
• W4321497624 cites W2000852562 @default.
• W4321497624 cites W2002519510 @default.
• W4321497624 cites W2003982930 @default.
• W4321497624 cites W2025116335 @default.
• W4321497624 cites W2043189848 @default.
• W4321497624 cites W2050508296 @default.
• W4321497624 cites W2051359369 @default.
• W4321497624 cites W2083315323 @default.
• W4321497624 cites W2086472415 @default.
• W4321497624 cites W2087146795 @default.
• W4321497624 cites W2103997793 @default.
• W4321497624 cites W2126795224 @default.
• W4321497624 cites W2127854743 @default.
• W4321497624 cites W2128703002 @default.
• W4321497624 cites W2148132316 @default.
• W4321497624 cites W2152958471 @default.
• W4321497624 cites W2340747659 @default.
• W4321497624 cites W2346391128 @default.
• W4321497624 cites W2416643466 @default.
• W4321497624 cites W2551251325 @default.
• W4321497624 cites W2605741546 @default.
• W4321497624 cites W2606918206 @default.
• W4321497624 cites W2712049910 @default.
• W4321497624 cites W2862552137 @default.
• W4321497624 cites W2937934820 @default.
• W4321497624 cites W2942284280 @default.
• W4321497624 cites W2975822783 @default.
• W4321497624 cites W2977675093 @default.
• W4321497624 cites W2980347030 @default.
• W4321497624 cites W3005877643 @default.
• W4321497624 cites W3025282583 @default.
• W4321497624 cites W3034105086 @default.
• W4321497624 cites W3034505053 @default.
• W4321497624 cites W3036454441 @default.
• W4321497624 cites W3037934445 @default.
• W4321497624 cites W3045973332 @default.
• W4321497624 cites W3084800981 @default.
• W4321497624 cites W3101181278 @default.
• W4321497624 cites W3115061260 @default.
• W4321497624 cites W3180853779 @default.
• W4321497624 cites W3194032198 @default.
• W4321497624 cites W3196804017 @default.
• W4321497624 cites W4221100697 @default.
• W4321497624 cites W4224279191 @default.
• W4321497624 cites W4295998041 @default.
• W4321497624 cites W4310038872 @default.
• W4321497624 cites W4310215201 @default.
• W4321497624 doi "https://doi.org/10.3389/fphar.2023.1124845" @default.
• W4321497624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36909184" @default.
• W4321497624 hasPublicationYear "2023" @default.
• W4321497624 type Work @default.
• W4321497624 citedByCount "3" @default.
• W4321497624 countsByYear W43214976242023 @default.
• W4321497624 crossrefType "journal-article" @default.
• W4321497624 hasAuthorship W4321497624A5026376619 @default.
• W4321497624 hasAuthorship W4321497624A5026731357 @default.
• W4321497624 hasAuthorship W4321497624A5050174686 @default.
• W4321497624 hasAuthorship W4321497624A5055151897 @default.
• W4321497624 hasAuthorship W4321497624A5059328163 @default.
• W4321497624 hasAuthorship W4321497624A5066862028 @default.
• W4321497624 hasAuthorship W4321497624A5081491205 @default.
• W4321497624 hasBestOaLocation W43214976241 @default.
• W4321497624 hasConcept C126322002 @default.
• W4321497624 hasConcept C134018914 @default.
• W4321497624 hasConcept C136449434 @default.
• W4321497624 hasConcept C136569192 @default.
• W4321497624 hasConcept C139719470 @default.
• W4321497624 hasConcept C162324750 @default.
• W4321497624 hasConcept C169760540 @default.
• W4321497624 hasConcept C170493617 @default.
• W4321497624 hasConcept C182704531 @default.
• W4321497624 hasConcept C203014093 @default.
• W4321497624 hasConcept C2776867660 @default.
• W4321497624 hasConcept C2776914184 @default.
• W4321497624 hasConcept C2778654844 @default.
• W4321497624 hasConcept C2779085643 @default.
• W4321497624 hasConcept C2779177272 @default.
• W4321497624 hasConcept C2779830541 @default.
• W4321497624 hasConcept C2780194698 @default.
• W4321497624 hasConcept C2781001258 @default.
• W4321497624 hasConcept C2781161787 @default.
• W4321497624 hasConcept C71924100 @default.
• W4321497624 hasConcept C86803240 @default.

• next