Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321499548> ?p ?o ?g. }
- W4321499548 abstract "Abstract Pathological placental inflammation increases the risk for several adult disorders, but these mediators are also expressed under homeostatic conditions, where their contribution to adult health outcomes is unknown. Here we define an expression signature of homeostatic inflammation in the term placenta and use expression quantitative trait loci (eQTLs) to create a polygenic score (PGS) predictive of its expression. Using this PGS in the UK Biobank we carried out a phenome-wide association study, followed by mendelian randomization and identified protective, sex-dependent effects of the placental module on cardiovascular and depressive outcomes. Genes differentially regulated by intra-amniotic infection and preterm birth were also over-represented within the module. Our data support a model where disruption of placental homeostatic inflammation, following preterm birth or intra-amniotic infection, contributes to the increased risk of depression and cardiovascular disease observed in these individuals. Finally, we identify aspirin as a putative modulator of this homeostatic inflammatory signature." @default.
- W4321499548 created "2023-02-23" @default.
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- W4321499548 creator A5073633671 @default.
- W4321499548 date "2023-02-21" @default.
- W4321499548 modified "2023-10-16" @default.
- W4321499548 title "Homeostatic inflammation in the placenta is protective against adult cardiovascular and depressive outcomes" @default.
- W4321499548 cites W1151864206 @default.
- W4321499548 cites W1420275956 @default.
- W4321499548 cites W1504401263 @default.
- W4321499548 cites W1520563745 @default.
- W4321499548 cites W1902575419 @default.
- W4321499548 cites W1974033269 @default.
- W4321499548 cites W1977391294 @default.
- W4321499548 cites W2009923059 @default.
- W4321499548 cites W2015470285 @default.
- W4321499548 cites W2026245311 @default.
- W4321499548 cites W2030342693 @default.
- W4321499548 cites W2030729694 @default.
- W4321499548 cites W2031492796 @default.
- W4321499548 cites W2038485346 @default.
- W4321499548 cites W2045949302 @default.
- W4321499548 cites W2047931806 @default.
- W4321499548 cites W2057197272 @default.
- W4321499548 cites W2098887960 @default.
- W4321499548 cites W2104336562 @default.
- W4321499548 cites W2113699335 @default.
- W4321499548 cites W2121734518 @default.
- W4321499548 cites W2128736149 @default.
- W4321499548 cites W2129340132 @default.
- W4321499548 cites W2145825942 @default.
- W4321499548 cites W2154015462 @default.
- W4321499548 cites W2156247618 @default.
- W4321499548 cites W2165444002 @default.
- W4321499548 cites W2169456326 @default.
- W4321499548 cites W2238851414 @default.
- W4321499548 cites W2332292689 @default.
- W4321499548 cites W2400827254 @default.
- W4321499548 cites W2432815617 @default.
- W4321499548 cites W2515897135 @default.
- W4321499548 cites W2549732759 @default.
- W4321499548 cites W2553830639 @default.
- W4321499548 cites W2605538435 @default.
- W4321499548 cites W2609460893 @default.
- W4321499548 cites W2732904266 @default.
- W4321499548 cites W2762591582 @default.
- W4321499548 cites W2770598799 @default.
- W4321499548 cites W2790940356 @default.
- W4321499548 cites W2794480084 @default.
- W4321499548 cites W2794779007 @default.
- W4321499548 cites W2803229193 @default.
- W4321499548 cites W2805983714 @default.
- W4321499548 cites W2818417770 @default.
- W4321499548 cites W2883755605 @default.
- W4321499548 cites W2898583289 @default.
- W4321499548 cites W2898759023 @default.
- W4321499548 cites W2900144939 @default.
- W4321499548 cites W2911487850 @default.
- W4321499548 cites W2919361526 @default.
- W4321499548 cites W2922637566 @default.
- W4321499548 cites W2933586548 @default.
- W4321499548 cites W2935716359 @default.
- W4321499548 cites W2936002515 @default.
- W4321499548 cites W2938551441 @default.
- W4321499548 cites W2945883683 @default.
- W4321499548 cites W2958615822 @default.
- W4321499548 cites W2960943033 @default.
- W4321499548 cites W2965635787 @default.
- W4321499548 cites W2980980552 @default.
- W4321499548 cites W3042830188 @default.
- W4321499548 cites W3092854319 @default.
- W4321499548 cites W3093023303 @default.
- W4321499548 cites W3095295339 @default.
- W4321499548 cites W3107626709 @default.
- W4321499548 cites W3120392574 @default.
- W4321499548 cites W3120679015 @default.
- W4321499548 cites W3126281164 @default.
- W4321499548 cites W3127294734 @default.
- W4321499548 cites W3127556601 @default.
- W4321499548 cites W3160448956 @default.
- W4321499548 cites W3178987458 @default.
- W4321499548 cites W3187226810 @default.
- W4321499548 cites W3201988987 @default.
- W4321499548 cites W3204167790 @default.
- W4321499548 cites W3205792145 @default.
- W4321499548 cites W4205900283 @default.
- W4321499548 cites W4206980763 @default.
- W4321499548 cites W4220887281 @default.
- W4321499548 cites W4226168421 @default.