Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321499812> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4321499812 endingPage "383" @default.
- W4321499812 startingPage "383" @default.
- W4321499812 abstract "Objective: Supratotal resection (SupTR) of glioblastoma allows for a superior long-term disease control and increases overall survival. On the other hand, aggressive conventional approaches, including gross total resections (GTR), are limited by the impairment risk of adjacent eloquent areas, which may cause severe postoperative functional morbidity. This study aimed to analyze institutional cases with respect to the potential survival benefits of additional resection, including lobectomy, as a paradigm for SupTR in patients of glioblastoma. Methods: Between 2014 and 2018, 15 patients with glioblastoma underwent SupTR (GTR and additional lobectomy) at the authors’ institution. The postoperative Karnofsky performance score (KPS), progression-free survival (PFS), and overall survival (OS) were analyzed for the patients. Results: Patients with SupTR showed significantly prolonged PFS and OS. The median PFS and OS values for the entire study group were 33.5 months (95% confidence intervals (CI): 18.5–57.3 months) and 49.1 months (95% CI: 24.7–86.6 months), respectively. Multivariate analysis revealed that the O6-DNA-methylguanine methyltransferase (MGMT) promoter methylation status was the only predictor for both superior PFS (p = 0.03, OR 5.7, 95% CI 1.0–49.8) and OS (p = 0.04, OR 6.5, 95% CI 1.1–40.2). There was no significant difference between the pre- and postoperative KPS scores. Conclusions: Our results suggest that SupTR with lobectomy allows for a superior PFS and OS without negatively affecting patient performance. However, due to the small number of patients, further studies that include more patients are needed." @default.
- W4321499812 created "2023-02-23" @default.
- W4321499812 creator A5031243739 @default.
- W4321499812 creator A5035256895 @default.
- W4321499812 creator A5037315685 @default.
- W4321499812 creator A5071928897 @default.
- W4321499812 date "2023-02-22" @default.
- W4321499812 modified "2023-10-02" @default.
- W4321499812 title "Supratotal Resection of Glioblastoma: Better Survival Outcome than Gross Total Resection" @default.
- W4321499812 cites W1882450096 @default.
- W4321499812 cites W1887747927 @default.
- W4321499812 cites W1969374483 @default.
- W4321499812 cites W1972093598 @default.
- W4321499812 cites W2001859971 @default.
- W4321499812 cites W2034716377 @default.
- W4321499812 cites W2047631667 @default.
- W4321499812 cites W2052566050 @default.
- W4321499812 cites W2064214863 @default.
- W4321499812 cites W2090139973 @default.
- W4321499812 cites W2096287682 @default.
- W4321499812 cites W2126809148 @default.
- W4321499812 cites W2134390196 @default.
- W4321499812 cites W2150988286 @default.
- W4321499812 cites W2164049072 @default.
- W4321499812 cites W2227408374 @default.
- W4321499812 cites W2323828687 @default.
- W4321499812 cites W2526011086 @default.
- W4321499812 cites W2598593030 @default.
- W4321499812 cites W2606452322 @default.
- W4321499812 cites W2732629724 @default.
- W4321499812 cites W2764209486 @default.
- W4321499812 cites W2800469107 @default.
- W4321499812 cites W2896027205 @default.
- W4321499812 cites W2917608491 @default.
- W4321499812 cites W3031224726 @default.
- W4321499812 cites W4250899941 @default.
- W4321499812 cites W9494978 @default.
- W4321499812 doi "https://doi.org/10.3390/jpm13030383" @default.
- W4321499812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36983564" @default.
- W4321499812 hasPublicationYear "2023" @default.
- W4321499812 type Work @default.
- W4321499812 citedByCount "2" @default.
- W4321499812 countsByYear W43214998122023 @default.
- W4321499812 crossrefType "journal-article" @default.
- W4321499812 hasAuthorship W4321499812A5031243739 @default.
- W4321499812 hasAuthorship W4321499812A5035256895 @default.
- W4321499812 hasAuthorship W4321499812A5037315685 @default.
- W4321499812 hasAuthorship W4321499812A5071928897 @default.
- W4321499812 hasBestOaLocation W43214998121 @default.
- W4321499812 hasConcept C126322002 @default.
- W4321499812 hasConcept C141071460 @default.
- W4321499812 hasConcept C143998085 @default.
- W4321499812 hasConcept C2776194525 @default.
- W4321499812 hasConcept C2910123053 @default.
- W4321499812 hasConcept C3019894029 @default.
- W4321499812 hasConcept C38180746 @default.
- W4321499812 hasConcept C44249647 @default.
- W4321499812 hasConcept C502942594 @default.
- W4321499812 hasConcept C71924100 @default.
- W4321499812 hasConceptScore W4321499812C126322002 @default.
- W4321499812 hasConceptScore W4321499812C141071460 @default.
- W4321499812 hasConceptScore W4321499812C143998085 @default.
- W4321499812 hasConceptScore W4321499812C2776194525 @default.
- W4321499812 hasConceptScore W4321499812C2910123053 @default.
- W4321499812 hasConceptScore W4321499812C3019894029 @default.
- W4321499812 hasConceptScore W4321499812C38180746 @default.
- W4321499812 hasConceptScore W4321499812C44249647 @default.
- W4321499812 hasConceptScore W4321499812C502942594 @default.
- W4321499812 hasConceptScore W4321499812C71924100 @default.
- W4321499812 hasIssue "3" @default.
- W4321499812 hasLocation W43214998121 @default.
- W4321499812 hasLocation W43214998122 @default.
- W4321499812 hasLocation W43214998123 @default.
- W4321499812 hasOpenAccess W4321499812 @default.
- W4321499812 hasPrimaryLocation W43214998121 @default.
- W4321499812 hasRelatedWork W201717253 @default.
- W4321499812 hasRelatedWork W2044980821 @default.
- W4321499812 hasRelatedWork W2096952915 @default.
- W4321499812 hasRelatedWork W2159986890 @default.
- W4321499812 hasRelatedWork W2216144508 @default.
- W4321499812 hasRelatedWork W2414949291 @default.
- W4321499812 hasRelatedWork W2623790224 @default.
- W4321499812 hasRelatedWork W3135597474 @default.
- W4321499812 hasRelatedWork W4239548780 @default.
- W4321499812 hasRelatedWork W4241510236 @default.
- W4321499812 hasVolume "13" @default.
- W4321499812 isParatext "false" @default.
- W4321499812 isRetracted "false" @default.
- W4321499812 workType "article" @default.