FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321502896> ?p ?o ?g. }

• W4321502896 endingPage "260" @default.
• W4321502896 startingPage "255" @default.
• W4321502896 abstract "•Direct LDL-C assay in children aged 2-6 years can be obtained in routine check-ups. •Family history for FH or premature CVD is not a reliable predictor in preschoolers. •On a population level positive family history is associated with higher LDL-C. Background Individuals with FH develop cardiovascular disease due to lifelong cumulative exposure to elevated LDL-C. Effective screening for FH is not yet established. Objective To evaluate the practicability of a FH screening by measuring directly the LDL-C in preschoolers. Methods LDL-C measurement through capillary blood sampling during the compulsory routine check-ups by the pediatrician in children aged 2 to 6 years including information on family history as dyslipidemia and/or premature cardiovascular disease in first and second grade of pedigrees. Results 15,009 children (52.2% males, median age 3.9 years [IQR 3.0-5.1]) participated in the study. Positive family history for hyperlipidemia was stated in 40.9% cases, in 12.0% also in at least one 1st degree relative. In the total cohort, median LDL-C was 93 mg/dL [IQR 79-109 mg/dL]. Boys had significantly higher LDL-C levels than girls (p < 0.0001), whereas there was no difference regarding their age (p = 0.757). Children from families with a positive history for hypercholesterolemia/dyslipidemia had significantly higher LDL-C levels (p < 0.001) and were more frequently among those with LDL-C values above 135 mg/dL (3.5 mmol/L, 96th percentile; 53.2% vs. 40.3%, p < 0.001) and those with LDL-C levels above 160 mg/dL (4.1 mmol/L, 99th percentile; 45.3% vs. 40.7%, p < 0.001) than children without positive family history. Conclusions Direct measurement of LDL-C levels in children at ages 2-6 years during the compulsory routine check-ups as well as at any voluntary visits to the pediatrician's office is practicable and delivers reliable information, which can be used for a FH screening strategy in the general population. Individuals with FH develop cardiovascular disease due to lifelong cumulative exposure to elevated LDL-C. Effective screening for FH is not yet established. To evaluate the practicability of a FH screening by measuring directly the LDL-C in preschoolers. LDL-C measurement through capillary blood sampling during the compulsory routine check-ups by the pediatrician in children aged 2 to 6 years including information on family history as dyslipidemia and/or premature cardiovascular disease in first and second grade of pedigrees. 15,009 children (52.2% males, median age 3.9 years [IQR 3.0-5.1]) participated in the study. Positive family history for hyperlipidemia was stated in 40.9% cases, in 12.0% also in at least one 1st degree relative. In the total cohort, median LDL-C was 93 mg/dL [IQR 79-109 mg/dL]. Boys had significantly higher LDL-C levels than girls (p < 0.0001), whereas there was no difference regarding their age (p = 0.757). Children from families with a positive history for hypercholesterolemia/dyslipidemia had significantly higher LDL-C levels (p < 0.001) and were more frequently among those with LDL-C values above 135 mg/dL (3.5 mmol/L, 96th percentile; 53.2% vs. 40.3%, p < 0.001) and those with LDL-C levels above 160 mg/dL (4.1 mmol/L, 99th percentile; 45.3% vs. 40.7%, p < 0.001) than children without positive family history. Direct measurement of LDL-C levels in children at ages 2-6 years during the compulsory routine check-ups as well as at any voluntary visits to the pediatrician's office is practicable and delivers reliable information, which can be used for a FH screening strategy in the general population." @default.
• W4321502896 created "2023-02-23" @default.
• W4321502896 creator A5017305166 @default.
• W4321502896 creator A5021568045 @default.
• W4321502896 creator A5024413040 @default.
• W4321502896 creator A5025661636 @default.
• W4321502896 creator A5026378883 @default.
• W4321502896 creator A5053835735 @default.
• W4321502896 date "2023-03-01" @default.
• W4321502896 modified "2023-10-14" @default.
• W4321502896 title "Direct LDL-C estimation in preschoolers: Practicable first step for FH screening" @default.
• W4321502896 cites W2032428593 @default.
• W4321502896 cites W2055010010 @default.
• W4321502896 cites W2071663212 @default.
• W4321502896 cites W2104299102 @default.
• W4321502896 cites W2116404316 @default.
• W4321502896 cites W2142627469 @default.
• W4321502896 cites W2165624352 @default.
• W4321502896 cites W2609543937 @default.
• W4321502896 cites W2741252257 @default.
• W4321502896 cites W2804801890 @default.
• W4321502896 cites W2893980284 @default.
• W4321502896 cites W2894066152 @default.
• W4321502896 cites W2901003402 @default.
• W4321502896 cites W2991192025 @default.
• W4321502896 cites W2992424641 @default.
• W4321502896 cites W3028800184 @default.
• W4321502896 doi "https://doi.org/10.1016/j.jacl.2023.02.004" @default.
• W4321502896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36858936" @default.
• W4321502896 hasPublicationYear "2023" @default.
• W4321502896 type Work @default.
• W4321502896 citedByCount "0" @default.
• W4321502896 crossrefType "journal-article" @default.
• W4321502896 hasAuthorship W4321502896A5017305166 @default.
• W4321502896 hasAuthorship W4321502896A5021568045 @default.
• W4321502896 hasAuthorship W4321502896A5024413040 @default.
• W4321502896 hasAuthorship W4321502896A5025661636 @default.
• W4321502896 hasAuthorship W4321502896A5026378883 @default.
• W4321502896 hasAuthorship W4321502896A5053835735 @default.
• W4321502896 hasConcept C105795698 @default.
• W4321502896 hasConcept C122048520 @default.
• W4321502896 hasConcept C126322002 @default.
• W4321502896 hasConcept C134018914 @default.
• W4321502896 hasConcept C187212893 @default.
• W4321502896 hasConcept C2778096610 @default.
• W4321502896 hasConcept C2778163477 @default.
• W4321502896 hasConcept C2779091943 @default.
• W4321502896 hasConcept C2779120738 @default.
• W4321502896 hasConcept C2779134260 @default.
• W4321502896 hasConcept C2781179581 @default.
• W4321502896 hasConcept C2908647359 @default.
• W4321502896 hasConcept C33923547 @default.
• W4321502896 hasConcept C555293320 @default.
• W4321502896 hasConcept C71924100 @default.
• W4321502896 hasConcept C72563966 @default.
• W4321502896 hasConcept C99454951 @default.
• W4321502896 hasConceptScore W4321502896C105795698 @default.
• W4321502896 hasConceptScore W4321502896C122048520 @default.
• W4321502896 hasConceptScore W4321502896C126322002 @default.
• W4321502896 hasConceptScore W4321502896C134018914 @default.
• W4321502896 hasConceptScore W4321502896C187212893 @default.
• W4321502896 hasConceptScore W4321502896C2778096610 @default.
• W4321502896 hasConceptScore W4321502896C2778163477 @default.
• W4321502896 hasConceptScore W4321502896C2779091943 @default.
• W4321502896 hasConceptScore W4321502896C2779120738 @default.
• W4321502896 hasConceptScore W4321502896C2779134260 @default.
• W4321502896 hasConceptScore W4321502896C2781179581 @default.
• W4321502896 hasConceptScore W4321502896C2908647359 @default.
• W4321502896 hasConceptScore W4321502896C33923547 @default.
• W4321502896 hasConceptScore W4321502896C555293320 @default.
• W4321502896 hasConceptScore W4321502896C71924100 @default.
• W4321502896 hasConceptScore W4321502896C72563966 @default.
• W4321502896 hasConceptScore W4321502896C99454951 @default.
• W4321502896 hasFunder F4320306172 @default.
• W4321502896 hasFunder F4320309446 @default.
• W4321502896 hasFunder F4320334498 @default.
• W4321502896 hasIssue "2" @default.
• W4321502896 hasLocation W43215028961 @default.
• W4321502896 hasLocation W43215028962 @default.
• W4321502896 hasOpenAccess W4321502896 @default.
• W4321502896 hasPrimaryLocation W43215028961 @default.
• W4321502896 hasRelatedWork W1856293137 @default.
• W4321502896 hasRelatedWork W2003447000 @default.
• W4321502896 hasRelatedWork W2018645250 @default.
• W4321502896 hasRelatedWork W2085392057 @default.
• W4321502896 hasRelatedWork W2092236618 @default.
• W4321502896 hasRelatedWork W2098362024 @default.
• W4321502896 hasRelatedWork W2157259602 @default.
• W4321502896 hasRelatedWork W2439278715 @default.
• W4321502896 hasRelatedWork W3112117237 @default.
• W4321502896 hasRelatedWork W4238248719 @default.
• W4321502896 hasVolume "17" @default.
• W4321502896 isParatext "false" @default.
• W4321502896 isRetracted "false" @default.
• W4321502896 workType "article" @default.