Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321601143> ?p ?o ?g. }
- W4321601143 endingPage "982" @default.
- W4321601143 startingPage "969" @default.
- W4321601143 abstract "Metastasis is the major cause of cancer-related death of cancer patients. Epithelial-mesenchymal transition (EMT) is one critical process during the cascade of tumor metastasis. EMT is a developmental program exploited by cancer cells to transition from epithelial state to mesenchymal state and confers metastatic properties as well as treatment resistance. Finding factors to inhibit EMT will greatly improve the prognosis patients. Spermatogenesis associated 2 (SPATA2) was originally isolated from human testis and proved playing a role in spermatogenesis. To date, however, the role of SPATA2 in oncogenesis is unknown. In the current study, by mining the public database and validating in a cohort of collected non-small cell lung cancer (NSCLC) specimens, we uncovered that the expression of SPATA2 positively correlated with the prognosis of patients and was an independent prognosis marker in NSCLC. Functional studies proved that ectopic overexpression of SPATA2 inhibited EMT resulting in impaired motility and invasiveness properties in vitro and metastasis in vivo, and increased radiosensitivity in NSCLC. Mechanistic investigation showed that SPATA2 could suppress the β-catenin signaling via attenuating DVL1 ubiquitination to achieve the functions. Taken together, the current study revealed an inhibitory role of SPATA2 on EMT and that SPATA2 could be a potential target for therapy of NSCLC." @default.
- W4321601143 created "2023-02-24" @default.
- W4321601143 creator A5002597187 @default.
- W4321601143 creator A5004476606 @default.
- W4321601143 creator A5044757881 @default.
- W4321601143 creator A5046893121 @default.
- W4321601143 creator A5048374246 @default.
- W4321601143 creator A5052086894 @default.
- W4321601143 creator A5084029581 @default.
- W4321601143 creator A5085481083 @default.
- W4321601143 creator A5090889094 @default.
- W4321601143 date "2023-02-22" @default.
- W4321601143 modified "2023-10-18" @default.
- W4321601143 title "<scp>SPATA2</scp> suppresses epithelial‐mesenchymal transition to inhibit metastasis and radiotherapy sensitivity in non–small cell lung cancer via impairing <scp>DVL1</scp>/β‐catenin signaling" @default.
- W4321601143 cites W1964847767 @default.
- W4321601143 cites W1988058295 @default.
- W4321601143 cites W1999082557 @default.
- W4321601143 cites W2003680843 @default.
- W4321601143 cites W2004252534 @default.
- W4321601143 cites W2006444511 @default.
- W4321601143 cites W2009393065 @default.
- W4321601143 cites W2029454644 @default.
- W4321601143 cites W2033962173 @default.
- W4321601143 cites W2055878176 @default.
- W4321601143 cites W2080232352 @default.
- W4321601143 cites W2086559511 @default.
- W4321601143 cites W2132834292 @default.
- W4321601143 cites W2134185120 @default.
- W4321601143 cites W2141077390 @default.
- W4321601143 cites W2158021558 @default.
- W4321601143 cites W2436312957 @default.
- W4321601143 cites W2481104931 @default.
- W4321601143 cites W2514355059 @default.
- W4321601143 cites W2517895740 @default.
- W4321601143 cites W2574819148 @default.
- W4321601143 cites W2734814598 @default.
- W4321601143 cites W2786843484 @default.
- W4321601143 cites W2802357699 @default.
- W4321601143 cites W2888486524 @default.
- W4321601143 cites W2914008581 @default.
- W4321601143 cites W2917837889 @default.
- W4321601143 cites W2966452581 @default.
- W4321601143 cites W2991262688 @default.
- W4321601143 cites W3017082393 @default.
- W4321601143 cites W3160466435 @default.
- W4321601143 cites W4211233744 @default.
- W4321601143 cites W4298325589 @default.
- W4321601143 cites W4321601143 @default.
- W4321601143 doi "https://doi.org/10.1111/1759-7714.14828" @default.
- W4321601143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36814090" @default.
- W4321601143 hasPublicationYear "2023" @default.
- W4321601143 type Work @default.
- W4321601143 citedByCount "2" @default.
- W4321601143 countsByYear W43216011432023 @default.
- W4321601143 crossrefType "journal-article" @default.
- W4321601143 hasAuthorship W4321601143A5002597187 @default.
- W4321601143 hasAuthorship W4321601143A5004476606 @default.
- W4321601143 hasAuthorship W4321601143A5044757881 @default.
- W4321601143 hasAuthorship W4321601143A5046893121 @default.
- W4321601143 hasAuthorship W4321601143A5048374246 @default.
- W4321601143 hasAuthorship W4321601143A5052086894 @default.
- W4321601143 hasAuthorship W4321601143A5084029581 @default.
- W4321601143 hasAuthorship W4321601143A5085481083 @default.
- W4321601143 hasAuthorship W4321601143A5090889094 @default.
- W4321601143 hasBestOaLocation W43216011431 @default.
- W4321601143 hasConcept C121608353 @default.
- W4321601143 hasConcept C126322002 @default.
- W4321601143 hasConcept C137620995 @default.
- W4321601143 hasConcept C143998085 @default.
- W4321601143 hasConcept C206684579 @default.
- W4321601143 hasConcept C2776256026 @default.
- W4321601143 hasConcept C2779013556 @default.
- W4321601143 hasConcept C502942594 @default.
- W4321601143 hasConcept C509974204 @default.
- W4321601143 hasConcept C555283112 @default.
- W4321601143 hasConcept C62478195 @default.
- W4321601143 hasConcept C71924100 @default.
- W4321601143 hasConcept C76419328 @default.
- W4321601143 hasConcept C86803240 @default.
- W4321601143 hasConcept C95444343 @default.
- W4321601143 hasConceptScore W4321601143C121608353 @default.
- W4321601143 hasConceptScore W4321601143C126322002 @default.
- W4321601143 hasConceptScore W4321601143C137620995 @default.
- W4321601143 hasConceptScore W4321601143C143998085 @default.
- W4321601143 hasConceptScore W4321601143C206684579 @default.
- W4321601143 hasConceptScore W4321601143C2776256026 @default.
- W4321601143 hasConceptScore W4321601143C2779013556 @default.
- W4321601143 hasConceptScore W4321601143C502942594 @default.
- W4321601143 hasConceptScore W4321601143C509974204 @default.
- W4321601143 hasConceptScore W4321601143C555283112 @default.
- W4321601143 hasConceptScore W4321601143C62478195 @default.
- W4321601143 hasConceptScore W4321601143C71924100 @default.
- W4321601143 hasConceptScore W4321601143C76419328 @default.
- W4321601143 hasConceptScore W4321601143C86803240 @default.
- W4321601143 hasConceptScore W4321601143C95444343 @default.
- W4321601143 hasFunder F4320321001 @default.
- W4321601143 hasFunder F4320335468 @default.
- W4321601143 hasIssue "11" @default.