Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321602232> ?p ?o ?g. }
- W4321602232 endingPage "104703" @default.
- W4321602232 startingPage "104703" @default.
- W4321602232 abstract "Several metal-based nanoparticles (NPs) have been found to be toxic and are known to exert adverse health outcomes with irreversible side effects. This highlights the need to discover effective, stable, and biocompatible therapeutic components using natural sources. Here, a hexane extract of Nigella sativa seeds was used to synthesize iron oxide NPs (NS-IONPs) embedded with N. sativa phytoconstituents. The extract acted as a reducing agent that restricted the size of the NS-IONPs to 5–6 nm, signifying the potential to be cleared through the renal system. The fabricated NS-IONPs had a prominent effect on pathogenic gram-negative bacteria, E. coli (19.3 mm) and Salmonella typhi (14.2 mm) and lung cancer cells (lowest IC50 of 18.75 µg/mL) mainly by binding to the phospholipid components of the cell membrane. This resulted in cell shrinkage and further inhibited cell growth. Transmission electron microscopy analyses revealed that the mechanisms of cellular NP uptake varied depending on the cell type. Accumulation of NS-IONPs inside the cell increased BAX expression and arrested the cells at the G0/G1 phase, thereby conspicuously extending the G0 phase to initiate necrosis. Thus, these finding suggest that the synthesized NS-IONPs exhibited high antibacterial activity and effective cytotoxicity against cancer cell lines A549 and HCT116 compared to IONPs. The innovation of the current study is that the biogenic fabrication of IONPs is simple and cost effective results in stable nanomaterial, NS-IONPs with potential antibacterial and anticancer activity, which can be explored furthermore for various biomedical applications." @default.
- W4321602232 created "2023-02-24" @default.
- W4321602232 creator A5015139221 @default.
- W4321602232 creator A5017859473 @default.
- W4321602232 creator A5038229123 @default.
- W4321602232 creator A5045712665 @default.
- W4321602232 creator A5057217216 @default.
- W4321602232 creator A5059396262 @default.
- W4321602232 creator A5084755666 @default.
- W4321602232 date "2023-06-01" @default.
- W4321602232 modified "2023-10-11" @default.
- W4321602232 title "Phytogenic fabrication of iron oxide nanoparticles and evaluation of their in vitro antibacterial and cytotoxic activity" @default.
- W4321602232 cites W1533049658 @default.
- W4321602232 cites W1735969114 @default.
- W4321602232 cites W1818850674 @default.
- W4321602232 cites W1911250742 @default.
- W4321602232 cites W2000430544 @default.
- W4321602232 cites W2005112341 @default.
- W4321602232 cites W2023542788 @default.
- W4321602232 cites W2030904288 @default.
- W4321602232 cites W2031743190 @default.
- W4321602232 cites W2044277801 @default.
- W4321602232 cites W2045261504 @default.
- W4321602232 cites W2053253397 @default.
- W4321602232 cites W2070262613 @default.
- W4321602232 cites W2118050759 @default.
- W4321602232 cites W2123781894 @default.
- W4321602232 cites W2160581431 @default.
- W4321602232 cites W2210316652 @default.
- W4321602232 cites W2412335728 @default.
- W4321602232 cites W2482441615 @default.
- W4321602232 cites W2605677382 @default.
- W4321602232 cites W2676887466 @default.
- W4321602232 cites W2728540916 @default.
- W4321602232 cites W2767684813 @default.
- W4321602232 cites W2775734282 @default.
- W4321602232 cites W2791293241 @default.
- W4321602232 cites W2806613787 @default.
- W4321602232 cites W2884937283 @default.
- W4321602232 cites W2885334779 @default.
- W4321602232 cites W2895497506 @default.
- W4321602232 cites W2896083352 @default.
- W4321602232 cites W2900946320 @default.
- W4321602232 cites W2903084758 @default.
- W4321602232 cites W2907124204 @default.
- W4321602232 cites W2912716858 @default.
- W4321602232 cites W2919384165 @default.
- W4321602232 cites W2933525006 @default.
- W4321602232 cites W2938749991 @default.
- W4321602232 cites W2941183806 @default.
- W4321602232 cites W2943671997 @default.
- W4321602232 cites W2956074157 @default.
- W4321602232 cites W2967099261 @default.
- W4321602232 cites W2969389203 @default.
- W4321602232 cites W2994618781 @default.
- W4321602232 cites W3013442735 @default.
- W4321602232 cites W3015201322 @default.
- W4321602232 cites W3033416815 @default.
- W4321602232 cites W3040902861 @default.
- W4321602232 cites W3088345745 @default.
- W4321602232 cites W3111089873 @default.
- W4321602232 cites W3119573036 @default.
- W4321602232 cites W3133650133 @default.
- W4321602232 cites W3139074090 @default.
- W4321602232 cites W3163638395 @default.
- W4321602232 cites W3212073657 @default.
- W4321602232 cites W4214819533 @default.
- W4321602232 doi "https://doi.org/10.1016/j.arabjc.2023.104703" @default.
- W4321602232 hasPublicationYear "2023" @default.
- W4321602232 type Work @default.
- W4321602232 citedByCount "2" @default.
- W4321602232 countsByYear W43216022322023 @default.
- W4321602232 crossrefType "journal-article" @default.
- W4321602232 hasAuthorship W4321602232A5015139221 @default.
- W4321602232 hasAuthorship W4321602232A5017859473 @default.
- W4321602232 hasAuthorship W4321602232A5038229123 @default.
- W4321602232 hasAuthorship W4321602232A5045712665 @default.
- W4321602232 hasAuthorship W4321602232A5057217216 @default.
- W4321602232 hasAuthorship W4321602232A5059396262 @default.
- W4321602232 hasAuthorship W4321602232A5084755666 @default.
- W4321602232 hasBestOaLocation W43216022321 @default.
- W4321602232 hasConcept C109316439 @default.
- W4321602232 hasConcept C12554922 @default.
- W4321602232 hasConcept C155672457 @default.
- W4321602232 hasConcept C171250308 @default.
- W4321602232 hasConcept C178790620 @default.
- W4321602232 hasConcept C185592680 @default.
- W4321602232 hasConcept C192562407 @default.
- W4321602232 hasConcept C202751555 @default.
- W4321602232 hasConcept C2777697756 @default.
- W4321602232 hasConcept C2778889443 @default.
- W4321602232 hasConcept C2780104969 @default.
- W4321602232 hasConcept C523546767 @default.
- W4321602232 hasConcept C54355233 @default.
- W4321602232 hasConcept C55493867 @default.
- W4321602232 hasConcept C86803240 @default.
- W4321602232 hasConceptScore W4321602232C109316439 @default.
- W4321602232 hasConceptScore W4321602232C12554922 @default.