FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321605900> ?p ?o ?g. }

• W4321605900 abstract "Abstract Background Gastric cancer (GC), gastroesophageal junction cancer (GEJC), and esophageal adenocarcinoma (EAC), together, are leading causes of cancer deaths worldwide. Patient health-related quality of life (HRQoL) and well-being has become increasingly important alongside traditional oncologic outcomes for both patients and clinicians and may aid treatment decisions. We conducted a survey to examine the clinical characteristics, humanistic burden, and the effects of first-line (1L) treatment in patients with GC/GEJC/EAC, across different geographic regions, to address the paucity of real-world data. Methods Clinicians treating patients with unresectable advanced or metastatic GC/GEJC/EAC in China, France, Germany, Japan, the United Kingdom, and the United States, during April–October 2019, were invited to provide data on their patients’ demographics, clinical characteristics, treatment, and HRQoL via medical chart reviews, clinician surveys, and patient questionnaires. Data were analyzed using descriptive statistics, regression analyses comparing active treatment and best supportive care. Patients were also stratified into subgroups that were identified either as human epidermal growth factor receptor 2 (HER2) positive, HER2 negative (which has a higher prevalence but for whom there are limited treatment options), or unknown HER2 status. Results Survey data were analyzed for 995 patients, 87% of whom were on active treatment, most commonly dual or triple chemotherapy. Demographics and clinical characteristics were similar across countries with most patients having GC and the lowest incidence of GEJC and EAC in China. Overall, most patients had de novo disease with good response to 1L treatment, while their HRQoL and well-being was significantly worse than the general population. In 682 patients on active treatment with HER2 negative or unknown status, HRQoL also appeared to be worse in those with recurrent disease. Regression analysis identified several drivers of treatment decisions and factors impacting patients’ HRQoL, including stage of disease and comorbidities. Conclusions In patients with advanced GC/GEJC/EAC, screening and assessment of HER2 status as well as patient-reported HRQoL outcomes are invaluable in aiding treatment decisions. The introduction of appropriate therapy soon after diagnosis has the prospect of achieving improved HRQoL and survival in these patients." @default.
• W4321605900 created "2023-02-24" @default.
• W4321605900 creator A5014306232 @default.
• W4321605900 creator A5020809319 @default.
• W4321605900 creator A5037659186 @default.
• W4321605900 creator A5042390338 @default.
• W4321605900 creator A5083020751 @default.
• W4321605900 date "2023-02-23" @default.
• W4321605900 modified "2023-10-18" @default.
• W4321605900 title "Global retrospective analysis of clinician- and patient-reported clinical characteristics and humanistic burden of patients with gastroesophageal cancers on first-line treatment" @default.
• W4321605900 cites W1484127751 @default.
• W4321605900 cites W1890874870 @default.
• W4321605900 cites W2000445173 @default.
• W4321605900 cites W2029540916 @default.
• W4321605900 cites W2040113387 @default.
• W4321605900 cites W2052146702 @default.
• W4321605900 cites W2066123107 @default.
• W4321605900 cites W2098428600 @default.
• W4321605900 cites W2121656227 @default.
• W4321605900 cites W2137329062 @default.
• W4321605900 cites W2149564130 @default.
• W4321605900 cites W2167112387 @default.
• W4321605900 cites W2272149632 @default.
• W4321605900 cites W2418436986 @default.
• W4321605900 cites W2473786944 @default.
• W4321605900 cites W2522769074 @default.
• W4321605900 cites W2570401594 @default.
• W4321605900 cites W2767195694 @default.
• W4321605900 cites W2787831475 @default.
• W4321605900 cites W2791479921 @default.
• W4321605900 cites W2792603544 @default.
• W4321605900 cites W2900604868 @default.
• W4321605900 cites W2902077240 @default.
• W4321605900 cites W2923878314 @default.
• W4321605900 cites W2944106172 @default.
• W4321605900 cites W2963629082 @default.
• W4321605900 cites W2973674273 @default.
• W4321605900 cites W2980149971 @default.
• W4321605900 cites W2994683483 @default.
• W4321605900 cites W2998120564 @default.
• W4321605900 cites W2998914340 @default.
• W4321605900 cites W3008121526 @default.
• W4321605900 cites W3024601476 @default.
• W4321605900 cites W3029494773 @default.
• W4321605900 cites W3034449190 @default.
• W4321605900 cites W3117254226 @default.
• W4321605900 cites W3126239108 @default.
• W4321605900 cites W3128646645 @default.
• W4321605900 cites W3171517418 @default.
• W4321605900 cites W4210685329 @default.
• W4321605900 doi "https://doi.org/10.1186/s12885-023-10553-7" @default.
• W4321605900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36823552" @default.
• W4321605900 hasPublicationYear "2023" @default.
• W4321605900 type Work @default.
• W4321605900 citedByCount "0" @default.
• W4321605900 crossrefType "journal-article" @default.
• W4321605900 hasAuthorship W4321605900A5014306232 @default.
• W4321605900 hasAuthorship W4321605900A5020809319 @default.
• W4321605900 hasAuthorship W4321605900A5037659186 @default.
• W4321605900 hasAuthorship W4321605900A5042390338 @default.
• W4321605900 hasAuthorship W4321605900A5083020751 @default.
• W4321605900 hasBestOaLocation W43216059001 @default.
• W4321605900 hasConcept C120665830 @default.
• W4321605900 hasConcept C121332964 @default.
• W4321605900 hasConcept C121608353 @default.
• W4321605900 hasConcept C126322002 @default.
• W4321605900 hasConcept C159110408 @default.
• W4321605900 hasConcept C2779951463 @default.
• W4321605900 hasConcept C2780140570 @default.
• W4321605900 hasConcept C512399662 @default.
• W4321605900 hasConcept C61511704 @default.
• W4321605900 hasConcept C71924100 @default.
• W4321605900 hasConceptScore W4321605900C120665830 @default.
• W4321605900 hasConceptScore W4321605900C121332964 @default.
• W4321605900 hasConceptScore W4321605900C121608353 @default.
• W4321605900 hasConceptScore W4321605900C126322002 @default.
• W4321605900 hasConceptScore W4321605900C159110408 @default.
• W4321605900 hasConceptScore W4321605900C2779951463 @default.
• W4321605900 hasConceptScore W4321605900C2780140570 @default.
• W4321605900 hasConceptScore W4321605900C512399662 @default.
• W4321605900 hasConceptScore W4321605900C61511704 @default.
• W4321605900 hasConceptScore W4321605900C71924100 @default.
• W4321605900 hasIssue "1" @default.
• W4321605900 hasLocation W43216059001 @default.
• W4321605900 hasLocation W43216059002 @default.
• W4321605900 hasLocation W43216059003 @default.
• W4321605900 hasOpenAccess W4321605900 @default.
• W4321605900 hasPrimaryLocation W43216059001 @default.
• W4321605900 hasRelatedWork W1580426574 @default.
• W4321605900 hasRelatedWork W1977732319 @default.
• W4321605900 hasRelatedWork W1984877488 @default.
• W4321605900 hasRelatedWork W2089620537 @default.
• W4321605900 hasRelatedWork W2275480158 @default.
• W4321605900 hasRelatedWork W2323950372 @default.
• W4321605900 hasRelatedWork W2371214482 @default.
• W4321605900 hasRelatedWork W2407004706 @default.
• W4321605900 hasRelatedWork W2929987155 @default.
• W4321605900 hasRelatedWork W4238089809 @default.
• W4321605900 hasVolume "23" @default.
• W4321605900 isParatext "false" @default.

• next