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- W4321615238 abstract "Neutralizing antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being developed world over. We investigated the possibility of producing artificial antibodies from the formalin fixation and paraffin-embedding (FFPE) lung lobes of a patient who died by coronavirus disease 2019 (COVID-19). The B-cell receptors repertoire in the lung tissue where SARS-CoV-2 was detected were considered to have highly sensitive virus-neutralizing activity, and artificial antibodies were produced by combining the most frequently detected heavy and light chains. Some neutralizing effects against the SARS-CoV-2 were observed, and mixing two different artificial antibodies had a higher tendency to suppress the virus. The neutralizing effects were similar to the immunoglobulin G obtained from healthy donors who had received a COVID-19 mRNA vaccine. Therefore, the use of FFPE lung tissue, which preserves the condition of direct virus sensitization, to generate artificial antibodies may be useful against future unknown infectious diseases." @default.
- W4321615238 created "2023-02-24" @default.
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- W4321615238 date "2023-02-23" @default.
- W4321615238 modified "2023-10-14" @default.
- W4321615238 title "B cell receptor repertoire analysis from autopsy samples of COVID-19 patients" @default.
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- W4321615238 doi "https://doi.org/10.3389/fimmu.2023.1034978" @default.
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