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- W4321639013 abstract "<h3>Background</h3> The accurate and prompt diagnosis of antibody-mediated rejection (ABMR) in paediatric kidney transplant recipients (pKTR) is vital in allowing the early initiation of treatment to prevent renal allograft dysfunction and loss. The important role of complement activation in renal transplant immunology and rejection has been described, especially when some pKTR can have circulating peripheral donor specific antibodies for years. There are limited data in the paediatric population identifying the presence and deposition of specific complement pro-inflammatory and inhibitory factors in suspected ABMR. <h3>Methods</h3> Retrospective, single-centre study of percutaneous renal transplant biopsies from 10 pKTR with donor-specific antibodies (DSA) and a histological diagnosis of ABMR, were retrieved for immunohistochemistry (IHC) staining between April 2017 and September 2017. The cases were reviewed for the expression of complement induced pro-inflammatory (SYK, C3D) and inhibitory (CD46, CD55, CD59) factors. <h3>Results</h3> CD59 staining was positive in all 10 biopsies with stronger staining in the peritubular capillaries and patchy staining in the proximal and distal tubules, without evidence of CD55 staining. CD46 showed mainly patchy staining in the basement membrane and occasionally patchy staining in the proximal and distal tubules. C3D staining showed predominantly strongly positive staining in glomerular capillaries, and occasional patchy staining in the tubules. SYK staining was strongly positive and confined to the distal tubules. <h3>Conclusions</h3> Our study confirms that complement regulating proteins have an important role in ABMR. It also suggests stronger protection against terminal complement by CD59 compared to the proximal regulators CD46 and CD55. Further studies are warranted to evaluate their role in diagnosing, classifying and treating ABMR, and to determine the potential role for complement targeted therapies." @default.
- W4321639013 created "2023-02-24" @default.
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- W4321639013 date "2023-02-01" @default.
- W4321639013 modified "2023-09-28" @default.
- W4321639013 title "12 Determining the role of complement pro-inflammatory factors and regulatory proteins in antibody-mediated rejection (ABMR) in paediatric kidney transplant recipients (pKTR)" @default.
- W4321639013 doi "https://doi.org/10.1136/archdischild-2023-gosh.12" @default.
- W4321639013 hasPublicationYear "2023" @default.
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