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- W4321749312 endingPage "49" @default.
- W4321749312 startingPage "1" @default.
- W4321749312 abstract "Endogenous estradiol (E2) exerts diverse physiological and pharmacological activities, commonly used for hormone replacement therapy. However, prolonged and excessive exposure to E2 potentially increases estrogenic cancer risk. Reportedly, CYP1 enzyme-mediated biotransformation of E2 is largely concerned with its balance between detoxification and carcinogenic pathways. Among the three key CYP1 enzymes (CYP1A1, CYP1A2, and CYP1B1), CYP1A1 and CYP1A2 mainly catalyze the formation of nontoxic 2-hydroxyestradiol (2-OH-E2), while CYP1B1 specifically catalyzes the formation of genotoxic 4-hydroxyestradiol (4-OH-E2). 4-OH-E2 can be further metabolized to electrophilic quinone intermediates accompanied by the generation of reactive oxygen species (ROS), triggering DNA damage. Since abnormal alterations in CYP1 activities can greatly affect the bioactivation process of E2, regulatory effects of xenobiotics on CYP1s are essential for E2-associated cancer development. To date, thousands of natural and synthetic compounds have been found to show potential inhibition and/or induction actions on the three CYP1 members. Generally, these chemicals share similar planar polycyclic skeletons, the structural motifs and substituent groups of which are important for their inhibitory/inductive efficiency and selectivity toward CYP1 enzymes. This review comprehensively summarizes these known inhibitors and/or inductors of E2-metabolizing CYP1s based on chemical categories and discusses their structure-activity relationships, which would contribute to better understanding of the correlation between xenobiotic-regulated CYP1 activities and estrogenic cancer susceptibility." @default.
- W4321749312 created "2023-02-25" @default.
- W4321749312 creator A5015575575 @default.
- W4321749312 creator A5052344287 @default.
- W4321749312 creator A5065859286 @default.
- W4321749312 date "2023-02-23" @default.
- W4321749312 modified "2023-09-23" @default.
- W4321749312 title "Effects of xenobiotics on CYP1 enzyme-mediated biotransformation and bioactivation of estradiol" @default.
- W4321749312 cites W1268162879 @default.
- W4321749312 cites W1963833048 @default.
- W4321749312 cites W1966294678 @default.
- W4321749312 cites W1967630373 @default.
- W4321749312 cites W1969612295 @default.
- W4321749312 cites W1969870510 @default.
- W4321749312 cites W1970655935 @default.
- W4321749312 cites W1973116405 @default.
- W4321749312 cites W1973592361 @default.
- W4321749312 cites W1978865356 @default.
- W4321749312 cites W1981521880 @default.
- W4321749312 cites W1982307198 @default.
- W4321749312 cites W1984720043 @default.
- W4321749312 cites W1984939504 @default.
- W4321749312 cites W1985222443 @default.
- W4321749312 cites W1986354204 @default.
- W4321749312 cites W1988411979 @default.
- W4321749312 cites W1988551553 @default.
- W4321749312 cites W1991056592 @default.
- W4321749312 cites W1994965036 @default.
- W4321749312 cites W1996048503 @default.
- W4321749312 cites W1998118464 @default.
- W4321749312 cites W1999491824 @default.
- W4321749312 cites W2003237988 @default.
- W4321749312 cites W2003705004 @default.
- W4321749312 cites W2004337431 @default.
- W4321749312 cites W2005103744 @default.
- W4321749312 cites W2005177013 @default.
- W4321749312 cites W2008411429 @default.
- W4321749312 cites W2008727945 @default.
- W4321749312 cites W2009082706 @default.
- W4321749312 cites W2009266960 @default.
- W4321749312 cites W2010427019 @default.
- W4321749312 cites W2010886541 @default.
- W4321749312 cites W2015192043 @default.
- W4321749312 cites W2016965610 @default.
- W4321749312 cites W2017967036 @default.
- W4321749312 cites W2018159079 @default.
- W4321749312 cites W2020251056 @default.
- W4321749312 cites W2021851827 @default.
- W4321749312 cites W2028921444 @default.
- W4321749312 cites W2031909185 @default.
- W4321749312 cites W2032196352 @default.
- W4321749312 cites W2033234613 @default.
- W4321749312 cites W2034311256 @default.
- W4321749312 cites W2034805981 @default.
- W4321749312 cites W2036402179 @default.
- W4321749312 cites W2038267090 @default.
- W4321749312 cites W2039319158 @default.
- W4321749312 cites W2039629375 @default.
- W4321749312 cites W2040459088 @default.
- W4321749312 cites W2041685866 @default.
- W4321749312 cites W2042199152 @default.
- W4321749312 cites W2043712625 @default.
- W4321749312 cites W2045561807 @default.
- W4321749312 cites W2050660880 @default.
- W4321749312 cites W2050948297 @default.
- W4321749312 cites W2052442334 @default.
- W4321749312 cites W2054639376 @default.
- W4321749312 cites W2058618472 @default.
- W4321749312 cites W2062753542 @default.
- W4321749312 cites W2064996975 @default.
- W4321749312 cites W2068772465 @default.
- W4321749312 cites W2069593769 @default.
- W4321749312 cites W2072729440 @default.
- W4321749312 cites W2074073688 @default.
- W4321749312 cites W2074451871 @default.
- W4321749312 cites W2075802999 @default.
- W4321749312 cites W2076267521 @default.
- W4321749312 cites W2078988238 @default.
- W4321749312 cites W2079085660 @default.
- W4321749312 cites W2080272820 @default.
- W4321749312 cites W2081500551 @default.
- W4321749312 cites W2082448349 @default.
- W4321749312 cites W2084075687 @default.
- W4321749312 cites W2086737804 @default.
- W4321749312 cites W2087335973 @default.
- W4321749312 cites W2088062399 @default.
- W4321749312 cites W2089076228 @default.
- W4321749312 cites W2089676696 @default.
- W4321749312 cites W2091893762 @default.
- W4321749312 cites W2093852491 @default.
- W4321749312 cites W2094879937 @default.
- W4321749312 cites W2095388315 @default.
- W4321749312 cites W2095396181 @default.
- W4321749312 cites W2097529071 @default.
- W4321749312 cites W2098395524 @default.
- W4321749312 cites W2099663261 @default.
- W4321749312 cites W2105524626 @default.
- W4321749312 cites W2111400269 @default.