FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321764606> ?p ?o ?g. }

• W4321764606 abstract "Deficiency for the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) leads to chromosomal instability and diseases such as cancer. Yet, defective HR also results in vulnerabilities that can be exploited for targeted therapy. Here, we identify such a vulnerability and show that BRCA1-deficient cells are dependent on the long-range end-resection factor EXO1 for survival. EXO1 loss results in DNA replication-induced lesions decorated by poly(ADP-ribose)-chains. In cells that lack both BRCA1 and EXO1, this is accompanied by unresolved DSBs due to impaired single-strand annealing (SSA), a DSB repair process that requires the activity of both proteins. In contrast, BRCA2-deficient cells have increased SSA, also in the absence of EXO1, and hence are not dependent on EXO1 for survival. In agreement with our mechanistic data, BRCA1-mutated tumours have elevated EXO1 expression and contain more genomic signatures of SSA compared to BRCA1-proficient tumours. Collectively, our data indicate that EXO1 is a promising novel target for treatment of BRCA1-deficient tumours." @default.
• W4321764606 created "2023-02-25" @default.
• W4321764606 creator A5000355154 @default.
• W4321764606 creator A5001682954 @default.
• W4321764606 creator A5012252615 @default.
• W4321764606 creator A5024568154 @default.
• W4321764606 creator A5025093429 @default.
• W4321764606 creator A5025708775 @default.
• W4321764606 creator A5027225750 @default.
• W4321764606 creator A5028769361 @default.
• W4321764606 creator A5051248838 @default.
• W4321764606 creator A5052378659 @default.
• W4321764606 creator A5064622785 @default.
• W4321764606 creator A5067900225 @default.
• W4321764606 creator A5071217665 @default.
• W4321764606 creator A5072084304 @default.
• W4321764606 creator A5091679060 @default.
• W4321764606 date "2023-02-24" @default.
• W4321764606 modified "2023-09-27" @default.
• W4321764606 title "EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells" @default.
• W4321764606 cites W1916817328 @default.
• W4321764606 cites W1966018310 @default.
• W4321764606 cites W1973268287 @default.
• W4321764606 cites W1976924852 @default.
• W4321764606 cites W1982957001 @default.
• W4321764606 cites W1993910101 @default.
• W4321764606 cites W2009007206 @default.
• W4321764606 cites W2011902133 @default.
• W4321764606 cites W2014091491 @default.
• W4321764606 cites W2021255875 @default.
• W4321764606 cites W2021703784 @default.
• W4321764606 cites W2022495797 @default.
• W4321764606 cites W2031211461 @default.
• W4321764606 cites W2037095827 @default.
• W4321764606 cites W2042134072 @default.
• W4321764606 cites W2043876753 @default.
• W4321764606 cites W2046535007 @default.
• W4321764606 cites W2070781513 @default.
• W4321764606 cites W2073569331 @default.
• W4321764606 cites W2074446011 @default.
• W4321764606 cites W2081383594 @default.
• W4321764606 cites W2082411289 @default.
• W4321764606 cites W2104003823 @default.
• W4321764606 cites W2106070783 @default.
• W4321764606 cites W2109003615 @default.
• W4321764606 cites W2113125265 @default.
• W4321764606 cites W2114860131 @default.
• W4321764606 cites W2115626825 @default.
• W4321764606 cites W2117265134 @default.
• W4321764606 cites W2122439785 @default.
• W4321764606 cites W2123645269 @default.
• W4321764606 cites W2126078599 @default.
• W4321764606 cites W2152440925 @default.
• W4321764606 cites W2157899948 @default.
• W4321764606 cites W2160999108 @default.
• W4321764606 cites W2161340431 @default.
• W4321764606 cites W2168396953 @default.
• W4321764606 cites W2172631200 @default.
• W4321764606 cites W2266606089 @default.
• W4321764606 cites W2278379148 @default.
• W4321764606 cites W2336105423 @default.
• W4321764606 cites W2344657883 @default.
• W4321764606 cites W2382242955 @default.
• W4321764606 cites W2443774396 @default.
• W4321764606 cites W2464252485 @default.
• W4321764606 cites W2476568892 @default.
• W4321764606 cites W2494243053 @default.
• W4321764606 cites W2597062310 @default.
• W4321764606 cites W2606336993 @default.
• W4321764606 cites W2614487508 @default.
• W4321764606 cites W2727479110 @default.
• W4321764606 cites W2734678671 @default.
• W4321764606 cites W2736499558 @default.
• W4321764606 cites W2754242788 @default.
• W4321764606 cites W2763077107 @default.
• W4321764606 cites W2795656593 @default.
• W4321764606 cites W2795993993 @default.
• W4321764606 cites W2852866740 @default.
• W4321764606 cites W2883664363 @default.
• W4321764606 cites W2896176648 @default.
• W4321764606 cites W2897156010 @default.
• W4321764606 cites W2914604310 @default.
• W4321764606 cites W2941159973 @default.
• W4321764606 cites W2950137068 @default.
• W4321764606 cites W2955620588 @default.
• W4321764606 cites W2966053746 @default.
• W4321764606 cites W2968820602 @default.
• W4321764606 cites W2976898289 @default.
• W4321764606 cites W2982112195 @default.
• W4321764606 cites W3004584205 @default.
• W4321764606 cites W3028304854 @default.
• W4321764606 cites W3033735360 @default.
• W4321764606 cites W3085743991 @default.
• W4321764606 cites W3095003868 @default.
• W4321764606 cites W3099886820 @default.
• W4321764606 cites W3125609455 @default.
• W4321764606 cites W3162487464 @default.
• W4321764606 cites W3176830741 @default.
• W4321764606 cites W3183902079 @default.
• W4321764606 cites W3185785576 @default.

• next