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• W4321768665 endingPage "104686" @default.
• W4321768665 startingPage "104686" @default.
• W4321768665 abstract "Persistent symptoms on short-term follow-up after infection with COVID-19 are common, but long-term consequences have been insufficiently studied. The aim of this study was to characterize pulmonary function and ongoing symptoms 12 months after hospitalization with COVID-19. This prospective multicenter study included 222 patients hospitalized with PCR-confirmed COVID-19 in the Central Denmark Region. Disease severity was stratified using WHO Clinical Progression Scale. Clinical characteristics, pulmonary function test (PFT), 6-minute walk test (6MWT), and patient-reported outcome measures were collected at follow-up 3 and 12 months after discharge. Outcome measures from follow-up 3 months after discharge have previously been published. A total of 179 (81%) patients completed the 12-month follow-up. Median age was 60 years (IQR 51, 69) and 58% were male patients. At 12-month follow-up 49.7% had a normal diffusion capacity for carbon monoxide (DLCO), while 39.4% had DLCO <80%. The 6MWT distance increased significantly (29m 95% CI 19, 40; p<0.01). An mMRC score of 0 was reported by 51% and an mMRC≥2 by 20%. The frequency and severity of fatigue, depression, and anxiety did not improve over time. The study found that impaired DLCO percentage is common 12 months after hospitalization with SARS-CoV-2 and reduction in DLCO percentage is associated to dyspnea." @default.
• W4321768665 created "2023-02-25" @default.
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• W4321768665 date "2023-02-01" @default.
• W4321768665 modified "2023-10-12" @default.
• W4321768665 title "Twelve-month follow-up after hospitalization for SARS-COV-2: physiology improves, symptoms remain" @default.
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• W4321768665 doi "https://doi.org/10.1016/j.idnow.2023.104686" @default.
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• W4321768665 hasPublicationYear "2023" @default.
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