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- W4321786706 endingPage "154" @default.
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- W4321786706 abstract "The pathogenic role of deregulated histone (de-)acetylation by histone deacetyles (HDACs) has been demonstrated in several human cancers. While some HDAC inhibitors (HDACi) have been approved for individual entities, for endocrine tumors such translation into clinical practice has not yet been achieved.Relevant results identified by structured searches in PubMed as well as in reference lists are summarized in a narrative review to discuss the current knowledge of HDAC involvement and their therapeutic relevance in endocrine tumors. For thyroid, neuroendocrine, and adrenal tumors, various oncogenic mechanisms of HDAC deregulation and effects of HDAC inhibitors (HDACi) have been identified in preclinical studies including direct cancer cell toxicity and modification of differentiation status.Based on positive pre-clinical results, the research on HDAC (inhibition) in the various endocrine tumors should be intensified - yet, it needs to be considered that i) HDACs' oncogenic actions might constitute only a part of epigenetic mechanisms driving cancer, ii) individual HDAC has different roles in different endocrine tumor entities, iii) inhibition of HDACs might be especially attractive in combination with conventional or other targeted therapies, and iv) new HDAC-inhibiting drugs with improved specificity or functionally modified HDACi might further improve their efficacy." @default.
- W4321786706 created "2023-02-25" @default.
- W4321786706 creator A5010743128 @default.
- W4321786706 creator A5017416078 @default.
- W4321786706 creator A5023411290 @default.
- W4321786706 creator A5059196549 @default.
- W4321786706 creator A5064726206 @default.
- W4321786706 creator A5086183279 @default.
- W4321786706 date "2023-03-04" @default.
- W4321786706 modified "2023-09-27" @default.
- W4321786706 title "HDACs as an emerging target in endocrine tumors: a comprehensive review" @default.
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