FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321788883> ?p ?o ?g. }

• W4321788883 abstract "Background: Epithelial-mesenchymal transition (EMT) is closely associated with cancer cell metastasis. Colon adenocarcinoma (COAD) is one of the most common malignancies in the world, and its metastasis leading to poor prognosis remains a challenge for clinicians. The purpose of this study was to explore the prognostic value of EMT-related genes (EMTRGs) by bioinformatics analysis and to develop a new EMTRGs prognostic signature for COAD. Methods: The TCGA-COAD dataset was downloaded from the TCGA portal as the training cohort, and the GSE17538 and GSE29621 datasets were obtained from the GEO database as the validation cohort. The best EMTRGs prognostic signature was constructed by differential expression analysis, Cox, and LASSO regression analysis. Gene set enrichment analysis (GSEA) is used to reveal pathways that are enriched in high-risk and low-risk groups. Differences in tumor immune cell levels were analyzed using microenvironmental cell population counter and single sample gene set enrichment analysis. Subclass mapping analysis and Genomics of Drug Sensitivity in Cancer were applied for prediction of immunotherapy response and chemotherapy response, respectively. Results: A total of 77 differentially expressed EMTRGs were identified in the TCGA-COAD cohort, and they were significantly associated with functions and pathways related to cancer cell metastasis, proliferation, and apoptosis. We constructed EMTRGs prognostic signature with COMP, MYL9, PCOLCE2, SCG2, and TIMP1 as new COAD prognostic biomarkers. The high-risk group had a poorer prognosis with enhanced immune cell infiltration. The GSEA demonstrated that the high-risk group was involved in ECM Receptor Interaction, WNT Signaling Pathway and Colorectal Cancer. Furthermore, patients with high risk scores may respond to anti-CTLA4 therapy and may be more resistant to targeted therapy agents BI 2536 and ABT-888. Conclusion: Together, we developed a new EMTRGs prognostic signature that can be an independent prognostic factor for COAD. This study has guiding implications for individualized counseling and treatment of COAD patients." @default.
• W4321788883 created "2023-02-25" @default.
• W4321788883 creator A5005277049 @default.
• W4321788883 creator A5033113453 @default.
• W4321788883 creator A5055875257 @default.
• W4321788883 creator A5061817335 @default.
• W4321788883 creator A5071407293 @default.
• W4321788883 creator A5071773009 @default.
• W4321788883 date "2023-02-24" @default.
• W4321788883 modified "2023-09-30" @default.
• W4321788883 title "An epithelial–mesenchymal transition-related mRNA signature associated with the prognosis, immune infiltration and therapeutic response of colon adenocarcinoma" @default.
• W4321788883 cites W1861714325 @default.
• W4321788883 cites W1960849084 @default.
• W4321788883 cites W1986203874 @default.
• W4321788883 cites W1990265423 @default.
• W4321788883 cites W2069440689 @default.
• W4321788883 cites W2069695705 @default.
• W4321788883 cites W2075294566 @default.
• W4321788883 cites W2130410032 @default.
• W4321788883 cites W2130430382 @default.
• W4321788883 cites W2171190137 @default.
• W4321788883 cites W2265419075 @default.
• W4321788883 cites W2340964572 @default.
• W4321788883 cites W2467902526 @default.
• W4321788883 cites W2533508881 @default.
• W4321788883 cites W2576724021 @default.
• W4321788883 cites W2600631691 @default.
• W4321788883 cites W2605082672 @default.
• W4321788883 cites W2789878273 @default.
• W4321788883 cites W2794157907 @default.
• W4321788883 cites W2796207838 @default.
• W4321788883 cites W2887304587 @default.
• W4321788883 cites W2891314908 @default.
• W4321788883 cites W2896442590 @default.
• W4321788883 cites W2901068426 @default.
• W4321788883 cites W2903466791 @default.
• W4321788883 cites W2904316920 @default.
• W4321788883 cites W2915834874 @default.
• W4321788883 cites W2930050789 @default.
• W4321788883 cites W2943895348 @default.
• W4321788883 cites W2951183091 @default.
• W4321788883 cites W2953578264 @default.
• W4321788883 cites W2954441087 @default.
• W4321788883 cites W2956140345 @default.
• W4321788883 cites W2973169637 @default.
• W4321788883 cites W3006100200 @default.
• W4321788883 cites W3012084551 @default.
• W4321788883 cites W3019294197 @default.
• W4321788883 cites W3028106501 @default.
• W4321788883 cites W3036772952 @default.
• W4321788883 cites W3044915036 @default.
• W4321788883 cites W3045679402 @default.
• W4321788883 cites W3048942453 @default.
• W4321788883 cites W3083720470 @default.
• W4321788883 cites W3085810340 @default.
• W4321788883 cites W3092222195 @default.
• W4321788883 cites W3093924329 @default.
• W4321788883 cites W3094348326 @default.
• W4321788883 cites W3107755801 @default.
• W4321788883 cites W3109922053 @default.
• W4321788883 cites W3113047044 @default.
• W4321788883 cites W3117437033 @default.
• W4321788883 cites W3118790373 @default.
• W4321788883 cites W3120595388 @default.
• W4321788883 cites W3128646645 @default.
• W4321788883 cites W3147148069 @default.
• W4321788883 cites W3147739291 @default.
• W4321788883 cites W3150492631 @default.
• W4321788883 cites W3151863197 @default.
• W4321788883 cites W3158512209 @default.
• W4321788883 cites W3162403113 @default.
• W4321788883 cites W3175984978 @default.
• W4321788883 cites W3186338877 @default.
• W4321788883 cites W3193293519 @default.
• W4321788883 cites W3194269637 @default.
• W4321788883 cites W3195607972 @default.
• W4321788883 cites W3196976863 @default.
• W4321788883 cites W3209200513 @default.
• W4321788883 cites W3210581746 @default.
• W4321788883 cites W3211165921 @default.
• W4321788883 cites W3212670168 @default.
• W4321788883 cites W3214048256 @default.
• W4321788883 cites W4200116133 @default.
• W4321788883 cites W4200214274 @default.
• W4321788883 cites W4206388417 @default.
• W4321788883 cites W4206479175 @default.
• W4321788883 cites W4210358516 @default.
• W4321788883 cites W4212874434 @default.
• W4321788883 cites W4220750583 @default.
• W4321788883 cites W4221099798 @default.
• W4321788883 cites W4224917684 @default.
• W4321788883 cites W4225655927 @default.
• W4321788883 cites W4226101064 @default.
• W4321788883 cites W4229041981 @default.
• W4321788883 cites W4280511367 @default.
• W4321788883 cites W4303940404 @default.
• W4321788883 doi "https://doi.org/10.3389/pore.2023.1611016" @default.
• W4321788883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36910014" @default.
• W4321788883 hasPublicationYear "2023" @default.
• W4321788883 type Work @default.

• next