Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321793133> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4321793133 endingPage "115310" @default.
- W4321793133 startingPage "115310" @default.
- W4321793133 abstract "Different Senecio species, especially S. inaequidens - a neophyte native to South Africa - have widely spread across Europe and now are found worldwide. The entire genus is known to contain toxic pyrrolizidine alkaloids (PAs), which renders them a possible health hazard to humans and livestock. As they can enter the food chain or occur as contaminants in herbal crops and phytopharmaceutical formulations (e.g. teas), efficient and straightforward assays for their qualitative and quantitative analysis are in high demand. Different techniques have been used for this purpose, most commonly HPLC or GC. As the analysis of PAs is a challenging task, alternative methodologies like ultra-high performance SFC (UHPSFC) may offer an additional benefit in terms of their separation efficiency and orthogonal selectivity. In this study an UHPSFC approach for the simultaneous determination of six PAs (free bases as well as N-oxides) is presented, which achieved the baseline separation of all standard compounds in seven min. Optimal separation was carried out in gradient mode on a Torus™ DEA column with 0.05% ammonia in methanol as modifier. The column temperature was 25 °C, ABPR 1900 psi and flow rate 1.1 mL/min, with a detection wavelength of 215 nm. The assay was validated and fulfilled all ICH criteria exhibiting good linearity (R2 ≥ 0.9994), precision (inter-day variance ≤ 3.67%, intra-day variance ≤ 3.92%) and recovery rates (96.3-104.1%), with detection limits typical for SFC-PDA (≤ 4.24 µg/mL). Furthermore, it could conveniently be coupled to MS-detection, which increased the sensitivity significantly. To confirm practical suitability of the method, different Senecio samples were analyzed, indicating a high qualitative as well as quantitative difference in their PA profile (e.g. total amounts of PA between 0.09 and 4.63 mg/g)." @default.
- W4321793133 created "2023-02-25" @default.
- W4321793133 creator A5008522457 @default.
- W4321793133 creator A5052458135 @default.
- W4321793133 creator A5070592083 @default.
- W4321793133 date "2023-05-01" @default.
- W4321793133 modified "2023-10-14" @default.
- W4321793133 title "Separation of pyrrolizidine alkaloids in different Senecio species using ultra-high performance supercritical fluid chromatography" @default.
- W4321793133 cites W1866888867 @default.
- W4321793133 cites W1971207900 @default.
- W4321793133 cites W1972794427 @default.
- W4321793133 cites W1981124894 @default.
- W4321793133 cites W1984396246 @default.
- W4321793133 cites W1998474720 @default.
- W4321793133 cites W2007703433 @default.
- W4321793133 cites W2011650948 @default.
- W4321793133 cites W2012441096 @default.
- W4321793133 cites W2018050438 @default.
- W4321793133 cites W2029746784 @default.
- W4321793133 cites W2039195731 @default.
- W4321793133 cites W2066459972 @default.
- W4321793133 cites W2084023079 @default.
- W4321793133 cites W2095608571 @default.
- W4321793133 cites W2159152727 @default.
- W4321793133 cites W2172753162 @default.
- W4321793133 cites W2286546832 @default.
- W4321793133 cites W2323846788 @default.
- W4321793133 cites W2415507181 @default.
- W4321793133 cites W2623350173 @default.
- W4321793133 cites W2759554991 @default.
- W4321793133 cites W2806011116 @default.
- W4321793133 cites W2920043055 @default.
- W4321793133 cites W2955212242 @default.
- W4321793133 cites W3000138532 @default.
- W4321793133 cites W3092996256 @default.
- W4321793133 cites W3208732044 @default.
- W4321793133 cites W358814872 @default.
- W4321793133 cites W4250251926 @default.
- W4321793133 cites W4302764057 @default.
- W4321793133 doi "https://doi.org/10.1016/j.jpba.2023.115310" @default.
- W4321793133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36863105" @default.
- W4321793133 hasPublicationYear "2023" @default.
- W4321793133 type Work @default.
- W4321793133 citedByCount "1" @default.
- W4321793133 countsByYear W43217931332023 @default.
- W4321793133 crossrefType "journal-article" @default.
- W4321793133 hasAuthorship W4321793133A5008522457 @default.
- W4321793133 hasAuthorship W4321793133A5052458135 @default.
- W4321793133 hasAuthorship W4321793133A5070592083 @default.
- W4321793133 hasBestOaLocation W43217931331 @default.
- W4321793133 hasConcept C179998833 @default.
- W4321793133 hasConcept C185592680 @default.
- W4321793133 hasConcept C203147553 @default.
- W4321793133 hasConcept C2775859528 @default.
- W4321793133 hasConcept C2779461572 @default.
- W4321793133 hasConcept C43617362 @default.
- W4321793133 hasConcept C59822182 @default.
- W4321793133 hasConcept C71240020 @default.
- W4321793133 hasConcept C86803240 @default.
- W4321793133 hasConceptScore W4321793133C179998833 @default.
- W4321793133 hasConceptScore W4321793133C185592680 @default.
- W4321793133 hasConceptScore W4321793133C203147553 @default.
- W4321793133 hasConceptScore W4321793133C2775859528 @default.
- W4321793133 hasConceptScore W4321793133C2779461572 @default.
- W4321793133 hasConceptScore W4321793133C43617362 @default.
- W4321793133 hasConceptScore W4321793133C59822182 @default.
- W4321793133 hasConceptScore W4321793133C71240020 @default.
- W4321793133 hasConceptScore W4321793133C86803240 @default.
- W4321793133 hasLocation W43217931331 @default.
- W4321793133 hasLocation W43217931332 @default.
- W4321793133 hasOpenAccess W4321793133 @default.
- W4321793133 hasPrimaryLocation W43217931331 @default.
- W4321793133 hasRelatedWork W137658126 @default.
- W4321793133 hasRelatedWork W1967260000 @default.
- W4321793133 hasRelatedWork W1979165521 @default.
- W4321793133 hasRelatedWork W2037171905 @default.
- W4321793133 hasRelatedWork W2037644494 @default.
- W4321793133 hasRelatedWork W2063908732 @default.
- W4321793133 hasRelatedWork W2094704771 @default.
- W4321793133 hasRelatedWork W2791334340 @default.
- W4321793133 hasRelatedWork W4321793133 @default.
- W4321793133 hasRelatedWork W62463899 @default.
- W4321793133 hasVolume "228" @default.
- W4321793133 isParatext "false" @default.
- W4321793133 isRetracted "false" @default.
- W4321793133 workType "article" @default.