Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321851566> ?p ?o ?g. }
- W4321851566 abstract "Abstract Ischemic stroke is associated with high mortality and morbidity rates worldwide. However, the molecular mechanisms underlying the neuronal damage incurred by stroke victims remain unclear. It has previously been reported that ischemic stroke can induce an increase in the levels of brain iron, which is an important factor of in the associated brain damage. Ferroportin 1 (FPN1), the only known cellular iron export protein, is found in brain microvascular endothelial cells (BMVECs) at the blood-brain barrier, and is considered the gateway for entry of plasma iron into the central nervous system. Despite the connection of brain iron to neuronal damage, the role of BMVECs FPN1 in ischemic stroke remains unexplored. Herein, we conditionally deleted Fpn1 in mouse endothelial cells (ECs), using VE-cadherin-Cre transgenic mice, and explored the impact on brain iron homeostasis after stroke. Our data demonstrated that Fpn1 knockout in ECs decreased the brain iron levels in mice, attenuated the oxidative stress and inflammatory responses after stroke, and inhibited both ferroptosis and apoptosis, ultimately alleviating neurological impairment and decreasing cerebral infarct volume during the acute phase of ischemic stroke. By contrast, we found that Fpn1 knockout in ECs delayed the recovery of neurological function in mice following ischemic stroke. We also found that ECs Fpn1 knockout decreased the brain iron levels after stroke, exacerbated glial cell proliferation, and inhibited neuronal development, indicating that the diminished brain iron levels hindered the repair of neural injury in mice. In conclusion, our findings reveal a dual consequence of FPN1 deficiency in ECs in the development of ischemic stroke. More specifically, iron deficiency initially exerts a neuroprotective effect during the acute phase of ischemic stroke but inhibits recovery during the later stages. Our findings are important to the development of iron- or FPN1-targeting therapeutics for the treatment of ischemic stroke." @default.
- W4321851566 created "2023-02-25" @default.
- W4321851566 creator A5021158030 @default.
- W4321851566 creator A5031320671 @default.
- W4321851566 creator A5032829757 @default.
- W4321851566 creator A5042775743 @default.
- W4321851566 creator A5055366697 @default.
- W4321851566 creator A5063627915 @default.
- W4321851566 creator A5071001756 @default.
- W4321851566 creator A5072808334 @default.
- W4321851566 creator A5073380317 @default.
- W4321851566 creator A5082650528 @default.
- W4321851566 date "2023-02-25" @default.
- W4321851566 modified "2023-10-18" @default.
- W4321851566 title "Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke" @default.
- W4321851566 cites W1594425991 @default.
- W4321851566 cites W1618001767 @default.
- W4321851566 cites W1737772948 @default.
- W4321851566 cites W1892595029 @default.
- W4321851566 cites W1969965209 @default.
- W4321851566 cites W1979107365 @default.
- W4321851566 cites W1988312440 @default.
- W4321851566 cites W2001177428 @default.
- W4321851566 cites W2004872316 @default.
- W4321851566 cites W2006418412 @default.
- W4321851566 cites W2007440356 @default.
- W4321851566 cites W2011992792 @default.
- W4321851566 cites W2017589879 @default.
- W4321851566 cites W2019211967 @default.
- W4321851566 cites W2033963984 @default.
- W4321851566 cites W2041715899 @default.
- W4321851566 cites W204521712 @default.
- W4321851566 cites W2046260941 @default.
- W4321851566 cites W2049228659 @default.
- W4321851566 cites W2054998458 @default.
- W4321851566 cites W2065566358 @default.
- W4321851566 cites W2072434736 @default.
- W4321851566 cites W2104704429 @default.
- W4321851566 cites W2115958127 @default.
- W4321851566 cites W2118200665 @default.
- W4321851566 cites W2127634810 @default.
- W4321851566 cites W2130601361 @default.
- W4321851566 cites W2134831823 @default.
- W4321851566 cites W2141003407 @default.
- W4321851566 cites W2146336916 @default.
- W4321851566 cites W2149844824 @default.
- W4321851566 cites W2155299988 @default.
- W4321851566 cites W2159383423 @default.
- W4321851566 cites W2162527851 @default.
- W4321851566 cites W2165092386 @default.
- W4321851566 cites W2165302236 @default.
- W4321851566 cites W2315662623 @default.
- W4321851566 cites W2351673993 @default.
- W4321851566 cites W2400419369 @default.
- W4321851566 cites W2474566658 @default.
- W4321851566 cites W2511335713 @default.
- W4321851566 cites W2520566194 @default.
- W4321851566 cites W2531529425 @default.
- W4321851566 cites W2559433778 @default.
- W4321851566 cites W2620099834 @default.
- W4321851566 cites W2793488506 @default.
- W4321851566 cites W2906120852 @default.
- W4321851566 cites W2920373067 @default.
- W4321851566 cites W2922447247 @default.
- W4321851566 cites W2953037856 @default.
- W4321851566 cites W2959218190 @default.
- W4321851566 cites W2998440386 @default.
- W4321851566 cites W3087015595 @default.
- W4321851566 cites W3092849554 @default.
- W4321851566 cites W3108338524 @default.
- W4321851566 cites W3160023208 @default.
- W4321851566 cites W3164239271 @default.
- W4321851566 cites W4210345586 @default.
- W4321851566 cites W4212764106 @default.
- W4321851566 cites W4229005747 @default.
- W4321851566 doi "https://doi.org/10.1038/s41419-023-05688-1" @default.
- W4321851566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36841833" @default.
- W4321851566 hasPublicationYear "2023" @default.
- W4321851566 type Work @default.
- W4321851566 citedByCount "3" @default.
- W4321851566 countsByYear W43218515662023 @default.
- W4321851566 crossrefType "journal-article" @default.
- W4321851566 hasAuthorship W4321851566A5021158030 @default.
- W4321851566 hasAuthorship W4321851566A5031320671 @default.
- W4321851566 hasAuthorship W4321851566A5032829757 @default.
- W4321851566 hasAuthorship W4321851566A5042775743 @default.
- W4321851566 hasAuthorship W4321851566A5055366697 @default.
- W4321851566 hasAuthorship W4321851566A5063627915 @default.
- W4321851566 hasAuthorship W4321851566A5071001756 @default.
- W4321851566 hasAuthorship W4321851566A5072808334 @default.
- W4321851566 hasAuthorship W4321851566A5073380317 @default.
- W4321851566 hasAuthorship W4321851566A5082650528 @default.
- W4321851566 hasBestOaLocation W43218515661 @default.
- W4321851566 hasConcept C102230213 @default.
- W4321851566 hasConcept C104317684 @default.
- W4321851566 hasConcept C126322002 @default.
- W4321851566 hasConcept C127413603 @default.
- W4321851566 hasConcept C141035611 @default.
- W4321851566 hasConcept C169760540 @default.
- W4321851566 hasConcept C170493617 @default.