Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322006677> ?p ?o ?g. }
- W4322006677 abstract "Whilst the pathophysiology at a cellular level has been defined, the cause of Parkinson’s disease (PD) remains poorly understood. This neurodegenerative disorder is associated with impaired dopamine transmission in the substantia nigra, and protein accumulations known as Lewy bodies are visible in affected neurons. Cell culture models of PD have indicated impaired mitochondrial function, so the focus of this paper is on the quality control processes involved in and around mitochondria. Mitochondrial autophagy (mitophagy) is the process through which defective mitochondria are removed from the cell by internalisation into autophagosomes which fuse with a lysosome. This process involves many proteins, notably including PINK1 and parkin, both of which are known to be coded on genes associated with PD. Normally in healthy individuals, PINK1 associates with the outer mitochondrial membrane, which then recruits parkin, activating it to attach ubiquitin proteins to the mitochondrial membrane. PINK1, parkin, and ubiquitin cooperate to form a positive feedback system which accelerates the deposition of ubiquitin on dysfunctional mitochondria, resulting in mitophagy. However, in hereditary PD, the genes encoding PINK1 and parkin are mutated, resulting in proteins that are less efficient at removing poorly performing mitochondria, leaving cells more vulnerable to oxidative stress and ubiquitinated inclusion bodies, such as Lewy bodies. Current research that looks into the connection between mitophagy and PD is promising, already yielding potentially therapeutic compounds; until now, pharmacological support for the mitophagy process has not been part of the therapeutic arsenal. Continued research in this area is warranted." @default.
- W4322006677 created "2023-02-26" @default.
- W4322006677 creator A5039179081 @default.
- W4322006677 creator A5071452279 @default.
- W4322006677 date "2023-02-25" @default.
- W4322006677 modified "2023-10-05" @default.
- W4322006677 title "Is Disrupted Mitophagy a Central Player to Parkinson’s Disease Pathology?" @default.
- W4322006677 cites W1146046970 @default.
- W4322006677 cites W114737604 @default.
- W4322006677 cites W1479935944 @default.
- W4322006677 cites W1489055978 @default.
- W4322006677 cites W1539994192 @default.
- W4322006677 cites W1541181512 @default.
- W4322006677 cites W1548036170 @default.
- W4322006677 cites W1577068987 @default.
- W4322006677 cites W1707209502 @default.
- W4322006677 cites W1812905037 @default.
- W4322006677 cites W1829183563 @default.
- W4322006677 cites W1876850155 @default.
- W4322006677 cites W1877873625 @default.
- W4322006677 cites W1963967499 @default.
- W4322006677 cites W1964485431 @default.
- W4322006677 cites W1967603366 @default.
- W4322006677 cites W1968843321 @default.
- W4322006677 cites W1969971911 @default.
- W4322006677 cites W1974778184 @default.
- W4322006677 cites W1977174816 @default.
- W4322006677 cites W1979408355 @default.
- W4322006677 cites W1979462186 @default.
- W4322006677 cites W1981089442 @default.
- W4322006677 cites W1983509809 @default.
- W4322006677 cites W1986335419 @default.
- W4322006677 cites W1989540944 @default.
- W4322006677 cites W1993098682 @default.
- W4322006677 cites W1996711072 @default.
- W4322006677 cites W1999469282 @default.
- W4322006677 cites W1999801453 @default.
- W4322006677 cites W2000730002 @default.
- W4322006677 cites W2002207189 @default.
- W4322006677 cites W2003069888 @default.
- W4322006677 cites W2006379278 @default.
- W4322006677 cites W2008560062 @default.
- W4322006677 cites W2009342682 @default.
- W4322006677 cites W2010717540 @default.
- W4322006677 cites W2013828402 @default.
- W4322006677 cites W2014300038 @default.
- W4322006677 cites W2018304425 @default.
- W4322006677 cites W2023448800 @default.
- W4322006677 cites W2023542615 @default.
- W4322006677 cites W2024656201 @default.
- W4322006677 cites W2026540198 @default.
- W4322006677 cites W2030504165 @default.
- W4322006677 cites W2038976751 @default.
- W4322006677 cites W2041255615 @default.
- W4322006677 cites W2044829505 @default.
- W4322006677 cites W2047256870 @default.
- W4322006677 cites W2048984899 @default.
- W4322006677 cites W2049528479 @default.
- W4322006677 cites W2051704317 @default.
- W4322006677 cites W2052243909 @default.
- W4322006677 cites W2052889619 @default.
- W4322006677 cites W2054193843 @default.
- W4322006677 cites W2056998843 @default.
- W4322006677 cites W2060516612 @default.
- W4322006677 cites W2064016373 @default.
- W4322006677 cites W2064445049 @default.
- W4322006677 cites W2065991187 @default.
- W4322006677 cites W2067112159 @default.
- W4322006677 cites W2067123002 @default.
- W4322006677 cites W2069581626 @default.
- W4322006677 cites W2074813364 @default.
- W4322006677 cites W2075058886 @default.
- W4322006677 cites W2075513888 @default.
- W4322006677 cites W2077883552 @default.
- W4322006677 cites W2079755405 @default.
- W4322006677 cites W2080421381 @default.
- W4322006677 cites W2082425146 @default.
- W4322006677 cites W2084735269 @default.
- W4322006677 cites W2089085990 @default.
- W4322006677 cites W2090505404 @default.
- W4322006677 cites W2098972637 @default.
- W4322006677 cites W2101341178 @default.
- W4322006677 cites W2103230459 @default.
- W4322006677 cites W2103296967 @default.
- W4322006677 cites W2104382960 @default.
- W4322006677 cites W2105477358 @default.
- W4322006677 cites W2106142195 @default.
- W4322006677 cites W2108113014 @default.
- W4322006677 cites W2108326484 @default.
- W4322006677 cites W2109326232 @default.
- W4322006677 cites W2112505333 @default.
- W4322006677 cites W2115524420 @default.
- W4322006677 cites W2116335531 @default.
- W4322006677 cites W2117924937 @default.
- W4322006677 cites W2123884205 @default.
- W4322006677 cites W2126478464 @default.
- W4322006677 cites W2128090246 @default.
- W4322006677 cites W2129917779 @default.
- W4322006677 cites W2131251654 @default.
- W4322006677 cites W2131709002 @default.