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- W4322007618 abstract "Background Overweight and obesity are common amongst women attending breast cancer Family History, Risk and Prevention Clinics (FHRPCs). Overweight increases risk of breast cancer (BC) and conditions including 1 cardiovascular disease (CVD) and type-2 diabetes (T2D). Clinics provide written health behaviour advice with is likely to have minimal effects. We assessed efficacy of two remotely delivered weight loss programmes vs. written advice. Method 210 women with overweight or obesity attending three UK FHRPCs were randomised to either a BC prevention programme (BCPP) framed to reduce risk of BC ( n = 86), a multiple disease prevention programme (MDPP) framed to reduce risk of BC, CVD and T2D ( n = 87), or written advice ( n = 37). Change in weight and health behaviours were assessed at 12-months. Results Weight loss at 12 months was −6.3% (−8.2, −4.5) in BCPP, −6.0% (−7.9, −4.2) in MDPP and −3.3% (−6.2, −0.5) in the written group ( p = 0.451 across groups). The percentage losing ≥10% weight in these groups were respectively 34%, 23% and 14% ( p = 0.038 across groups). Discussion BCPP and MDPP programmes resulted in more women achieving ≥10% weight loss, but no evidence of additional benefits of MDPP. A multicentre RCT to test the BCPP across UK FHRPCs is warranted. Clinical Trial Registration ISRCTN16431108." @default.
- W4322007618 created "2023-02-26" @default.
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- W4322007618 date "2023-02-25" @default.
- W4322007618 modified "2023-10-18" @default.
- W4322007618 title "Randomised controlled trial of breast cancer and multiple disease prevention weight loss programmes vs written advice amongst women attending a breast cancer family history clinic" @default.
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- W4322007618 doi "https://doi.org/10.1038/s41416-023-02207-z" @default.
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