FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322009038> ?p ?o ?g. }

• W4322009038 abstract "ABSTRACT Memory engrams are both necessary and sufficient to mediate behavioral outputs. Defensive behaviors such as freezing and avoidance are commonly examined during hippocampal-mediated fear engram reactivation, yet how reactivation of these cellular populations across different contexts engages the brain to produce a variety of defensive behaviors is relatively unclear. To address this, we first optogenetically reactivated a tagged fear engram in the dentate gyrus (DG) subregion of the hippocampus across three distinct contexts. We found that there were differential amounts of light-induced freezing depending on the size of the context in which reactivation occurred: mice demonstrated robust light-induced freezing in the most spatially restricted of the three contexts but not in the largest. We then utilized graph theoretical analyses to identify brain-wide alterations in cFos co-activation during engram reactivation across the smallest and largest contexts. Our manipulations conferred greater positive cFos correlations and recruited regions spanning putative fear and defense systems as hubs in the respective networks. Moreover, reactivating DG-mediated engrams generated network topologies across experimental conditions, emphasizing both shared and distinct features. By identifying and manipulating the circuits supporting memory function, as well as their corresponding brain-wide activity patterns, it is thereby possible to resolve systems-level biological mechanisms mediating memory’s capacity to modulate behavioral states. SIGNIFICANCE STATEMENT Implementing appropriate defensive behaviors across disparate environments is essential for survival. Memories can be used to select these responses. Recent work identified and artificially manipulated cellular ensembles within the hippocampus that mediate fear memory recall, yet how these populations engage brain-wide pathways that mediate defensive behaviors under environmental contingencies is unclear. We demonstrated here that reactivation across environments of various sizes elicits different behavioral responses and corresponding brain-wide network dynamics. These findings establish the flexibility of memory-bearing ensembles in generating brain and behavior states." @default.
• W4322009038 created "2023-02-26" @default.
• W4322009038 creator A5007872169 @default.
• W4322009038 creator A5021268614 @default.
• W4322009038 creator A5023493887 @default.
• W4322009038 creator A5042819869 @default.
• W4322009038 creator A5044060597 @default.
• W4322009038 creator A5050878903 @default.
• W4322009038 creator A5075668451 @default.
• W4322009038 creator A5079272543 @default.
• W4322009038 creator A5084947597 @default.
• W4322009038 creator A5087615520 @default.
• W4322009038 creator A5089421577 @default.
• W4322009038 date "2023-02-24" @default.
• W4322009038 modified "2023-10-06" @default.
• W4322009038 title "Hippocampal engrams generate flexible behavioral responses and brain-wide network states" @default.
• W4322009038 cites W1487216741 @default.
• W4322009038 cites W1505984050 @default.
• W4322009038 cites W1507396199 @default.
• W4322009038 cites W1547865271 @default.
• W4322009038 cites W1828920277 @default.
• W4322009038 cites W1921862095 @default.
• W4322009038 cites W1937980604 @default.
• W4322009038 cites W1968714114 @default.
• W4322009038 cites W1971994650 @default.
• W4322009038 cites W1972768039 @default.
• W4322009038 cites W1980006923 @default.
• W4322009038 cites W1987395516 @default.
• W4322009038 cites W1990592723 @default.
• W4322009038 cites W1991236735 @default.
• W4322009038 cites W1994389924 @default.
• W4322009038 cites W2001477070 @default.
• W4322009038 cites W2005476331 @default.
• W4322009038 cites W2012844042 @default.
• W4322009038 cites W2013375585 @default.
• W4322009038 cites W2017246888 @default.
• W4322009038 cites W2017586792 @default.
• W4322009038 cites W2017987256 @default.
• W4322009038 cites W2042847262 @default.
• W4322009038 cites W2046015860 @default.
• W4322009038 cites W2047541308 @default.
• W4322009038 cites W2051005796 @default.
• W4322009038 cites W2058711140 @default.
• W4322009038 cites W2068252829 @default.
• W4322009038 cites W2082235945 @default.
• W4322009038 cites W2089767272 @default.
• W4322009038 cites W2104806243 @default.
• W4322009038 cites W2110659025 @default.
• W4322009038 cites W2131681506 @default.
• W4322009038 cites W2137155095 @default.
• W4322009038 cites W2140201388 @default.
• W4322009038 cites W2155505956 @default.
• W4322009038 cites W2205794177 @default.
• W4322009038 cites W2236432672 @default.
• W4322009038 cites W2299967951 @default.
• W4322009038 cites W2410446460 @default.
• W4322009038 cites W2415217866 @default.
• W4322009038 cites W2427840519 @default.
• W4322009038 cites W2469176136 @default.
• W4322009038 cites W2487041855 @default.
• W4322009038 cites W2497649352 @default.
• W4322009038 cites W2520811319 @default.
• W4322009038 cites W2580493263 @default.
• W4322009038 cites W2601947439 @default.
• W4322009038 cites W2605419237 @default.
• W4322009038 cites W2605615531 @default.
• W4322009038 cites W2787419526 @default.
• W4322009038 cites W2802438942 @default.
• W4322009038 cites W2904533595 @default.
• W4322009038 cites W2920805976 @default.
• W4322009038 cites W2922428053 @default.
• W4322009038 cites W2945623725 @default.
• W4322009038 cites W2948352443 @default.
• W4322009038 cites W2952157926 @default.
• W4322009038 cites W2964024465 @default.
• W4322009038 cites W2975634117 @default.
• W4322009038 cites W2998470023 @default.
• W4322009038 cites W3080181386 @default.
• W4322009038 cites W3089208116 @default.
• W4322009038 cites W3134120952 @default.
• W4322009038 cites W3154021207 @default.
• W4322009038 cites W3154972878 @default.
• W4322009038 cites W371353707 @default.
• W4322009038 doi "https://doi.org/10.1101/2023.02.24.529744" @default.
• W4322009038 hasPublicationYear "2023" @default.
• W4322009038 type Work @default.
• W4322009038 citedByCount "1" @default.
• W4322009038 countsByYear W43220090382023 @default.
• W4322009038 crossrefType "posted-content" @default.
• W4322009038 hasAuthorship W4322009038A5007872169 @default.
• W4322009038 hasAuthorship W4322009038A5021268614 @default.
• W4322009038 hasAuthorship W4322009038A5023493887 @default.
• W4322009038 hasAuthorship W4322009038A5042819869 @default.
• W4322009038 hasAuthorship W4322009038A5044060597 @default.
• W4322009038 hasAuthorship W4322009038A5050878903 @default.
• W4322009038 hasAuthorship W4322009038A5075668451 @default.
• W4322009038 hasAuthorship W4322009038A5079272543 @default.
• W4322009038 hasAuthorship W4322009038A5084947597 @default.
• W4322009038 hasAuthorship W4322009038A5087615520 @default.
• W4322009038 hasAuthorship W4322009038A5089421577 @default.

• next