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- W4322009214 abstract "Precise control of tissue temperature during Laser-Induced Thermotherapy (LITT) procedures has the potential to improve the clinical efficiency and safety of such minimally invasive therapies. We present a method to automatically regulate in vivo the temperature increase during LITT using real-time rapid volumetric Magnetic Resonance thermometry (8 slices acquired every second, with an in-plane resolution of 1.4 mmx1.4 mm and a slice thickness of 3 mm) using the proton-resonance frequency (PRF) shift technique. The laser output power is adjusted every second using a feedback control algorithm (proportional-integral-derivative controller) to force maximal tissue temperature in the targeted region to follow a predefined temperature-time profile. The root-mean-square of the difference between the target temperature and the measured temperature ranged between 0.5 °C and 1.4 °C, for temperature increases between + 5 °C to + 30 °C above body temperature and a long heating duration (up to 15 min), showing excellent accuracy and stability of the method. These results were obtained on a 1.5 T clinical MRI scanner, showing a potential immediate clinical application of such a temperature controller during MR-guided LITT." @default.
- W4322009214 created "2023-02-26" @default.
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- W4322009214 date "2023-02-25" @default.
- W4322009214 modified "2023-10-01" @default.
- W4322009214 title "Real-time automatic temperature regulation during in vivo MRI-guided laser-induced thermotherapy (MR-LITT)" @default.
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- W4322009214 doi "https://doi.org/10.1038/s41598-023-29818-z" @default.
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