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• W4322012247 abstract "There have pieces of evidence of the distinct aberrant functional network topology profile in bipolar disorder (BD) across mania, depression, and euthymic episodes. However, the underlying anatomical network topology pattern in BD across different episodes is unclear.We calculated the whole-brain probabilistic structurally connectivity across 143 subjects (72 with BD [34 depression; 13 mania; 25 euthymic] and 53 healthy controls), and used graph theory to examine the trait- and state-related topology alterations of the structural connectome in BD. The correlation analysis was further conducted to explore the relationship between detected network measures and clinical symptoms.There no omnibus alteration of any global network metrics were observed across all diagnostic groups. In the regional network metrics level, bipolar depression showed increased clustering coefficient in the right lingual gyrus compared with all other groups, and the increased clustering coefficient in the right lingual gyrus positively correlated with depression, anxiety, and illness burden symptoms but negatively correlated with mania symptoms; manic and euthymic patients showed decreased clustering coefficient in the left inferior occipital gyrus compared with HCs.The moderate sample size of all patient groups (especially for subjects with mania) might have contributed to the negative findings of the trait feature in this study.We demonstrated the altered regional connectivity pattern in the occipital lobe of the bipolar depression and mania episode, especially the lingual gyrus. The association of the clustering coefficient in the lingual gyrus with clinical symptoms helps monitor the state of BD." @default.
• W4322012247 created "2023-02-26" @default.
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• W4322012247 date "2023-05-01" @default.
• W4322012247 modified "2023-10-15" @default.
• W4322012247 title "The anatomical networks based on probabilistic structurally connectivity in bipolar disorder across mania, depression, and euthymic states" @default.
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• W4322012247 doi "https://doi.org/10.1016/j.jad.2023.02.109" @default.
• W4322012247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36842653" @default.
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