Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322152898> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4322152898 endingPage "13" @default.
- W4322152898 startingPage "13" @default.
- W4322152898 abstract "Background: Sepsis is a state of systemic inflammation due to an infectious etiology that may lead to multisystem dysfunction, hemodynamic instability, and even death. It has been postulated that there may be an underlying immunomodulatory process resulting from rapid and exaggerated activation of macrophages that results in a cytokine storm and the development of macrophage activation syndrome (MAS). Adding immunomodulation to standard therapy (antibiotics and supportive care) can improve the prognosis. Clinical Description: We present a series of three young children who presented with the clinical features of sepsis. All three showed poor clinical response to management with timely antibiotics and supportive care, even after 48–72 h of initiation. In addition, there was the development of thrombocytopenia and transaminitis. The suspicion of MAS prompted us to order ferritin, triglyceride, and fibrinogen levels and applies the 2016 diagnostic criteria for MAS. These were satisfied, thus establishing the diagnosis. Management: In all three cases, immunomodulatory agents (intravenous immunoglobulin with or without pulses of methylprednisolone) were added, after which there was a clinical improvement, normalization of biomarkers, and complete recovery. Conclusion: Early immunomodulatory therapy, in addition to antibiotics, is beneficial in the successful treatment of children presenting with sepsis-induced MAS, thus preventing further morbidity and mortality and improving outcomes." @default.
- W4322152898 created "2023-02-27" @default.
- W4322152898 creator A5028656797 @default.
- W4322152898 creator A5032915189 @default.
- W4322152898 creator A5059741072 @default.
- W4322152898 creator A5067503437 @default.
- W4322152898 creator A5078331480 @default.
- W4322152898 date "2023-01-01" @default.
- W4322152898 modified "2023-09-24" @default.
- W4322152898 title "Immunomodulation in sepsis-induced macrophage activation syndrome in children" @default.
- W4322152898 cites W1977330237 @default.
- W4322152898 cites W1981427380 @default.
- W4322152898 cites W2052233685 @default.
- W4322152898 cites W2085128602 @default.
- W4322152898 cites W2085382520 @default.
- W4322152898 cites W2119893731 @default.
- W4322152898 cites W2151554745 @default.
- W4322152898 cites W2568091469 @default.
- W4322152898 cites W2619168870 @default.
- W4322152898 cites W2904470232 @default.
- W4322152898 doi "https://doi.org/10.4103/ipcares.ipcares_146_22" @default.
- W4322152898 hasPublicationYear "2023" @default.
- W4322152898 type Work @default.
- W4322152898 citedByCount "0" @default.
- W4322152898 crossrefType "journal-article" @default.
- W4322152898 hasAuthorship W4322152898A5028656797 @default.
- W4322152898 hasAuthorship W4322152898A5032915189 @default.
- W4322152898 hasAuthorship W4322152898A5059741072 @default.
- W4322152898 hasAuthorship W4322152898A5067503437 @default.
- W4322152898 hasAuthorship W4322152898A5078331480 @default.
- W4322152898 hasConcept C126322002 @default.
- W4322152898 hasConcept C177713679 @default.
- W4322152898 hasConcept C203014093 @default.
- W4322152898 hasConcept C203987217 @default.
- W4322152898 hasConcept C2776914184 @default.
- W4322152898 hasConcept C2777077863 @default.
- W4322152898 hasConcept C2778384902 @default.
- W4322152898 hasConcept C2778734968 @default.
- W4322152898 hasConcept C2779134260 @default.
- W4322152898 hasConcept C2779559532 @default.
- W4322152898 hasConcept C2779613421 @default.
- W4322152898 hasConcept C2780372218 @default.
- W4322152898 hasConcept C3008058167 @default.
- W4322152898 hasConcept C501593827 @default.
- W4322152898 hasConcept C524204448 @default.
- W4322152898 hasConcept C71924100 @default.
- W4322152898 hasConcept C86803240 @default.
- W4322152898 hasConcept C89423630 @default.
- W4322152898 hasConceptScore W4322152898C126322002 @default.
- W4322152898 hasConceptScore W4322152898C177713679 @default.
- W4322152898 hasConceptScore W4322152898C203014093 @default.
- W4322152898 hasConceptScore W4322152898C203987217 @default.
- W4322152898 hasConceptScore W4322152898C2776914184 @default.
- W4322152898 hasConceptScore W4322152898C2777077863 @default.
- W4322152898 hasConceptScore W4322152898C2778384902 @default.
- W4322152898 hasConceptScore W4322152898C2778734968 @default.
- W4322152898 hasConceptScore W4322152898C2779134260 @default.
- W4322152898 hasConceptScore W4322152898C2779559532 @default.
- W4322152898 hasConceptScore W4322152898C2779613421 @default.
- W4322152898 hasConceptScore W4322152898C2780372218 @default.
- W4322152898 hasConceptScore W4322152898C3008058167 @default.
- W4322152898 hasConceptScore W4322152898C501593827 @default.
- W4322152898 hasConceptScore W4322152898C524204448 @default.
- W4322152898 hasConceptScore W4322152898C71924100 @default.
- W4322152898 hasConceptScore W4322152898C86803240 @default.
- W4322152898 hasConceptScore W4322152898C89423630 @default.
- W4322152898 hasIssue "1" @default.
- W4322152898 hasLocation W43221528981 @default.
- W4322152898 hasOpenAccess W4322152898 @default.
- W4322152898 hasPrimaryLocation W43221528981 @default.
- W4322152898 hasRelatedWork W2036307020 @default.
- W4322152898 hasRelatedWork W2331492309 @default.
- W4322152898 hasRelatedWork W2416648174 @default.
- W4322152898 hasRelatedWork W2934953589 @default.
- W4322152898 hasRelatedWork W3011483549 @default.
- W4322152898 hasRelatedWork W3156789540 @default.
- W4322152898 hasRelatedWork W3181993135 @default.
- W4322152898 hasRelatedWork W3204096812 @default.
- W4322152898 hasRelatedWork W4206254929 @default.
- W4322152898 hasRelatedWork W4317611848 @default.
- W4322152898 hasVolume "3" @default.
- W4322152898 isParatext "false" @default.
- W4322152898 isRetracted "false" @default.
- W4322152898 workType "article" @default.