Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322154619> ?p ?o ?g. }
- W4322154619 endingPage "104982" @default.
- W4322154619 startingPage "104982" @default.
- W4322154619 abstract "Cerebral small vessel disease (SVD), which is highly age-related, is the most common neuroimaging finding in community-dwelling elderly individuals. In addition to increasing the risk of dementia and stroke, SVD is associated with cognitive and physical (particularly gait speed) functional impairments in the elderly. Here, we provide evidence suggesting covert SVD, e.g. without clinically evident stroke or dementia, as a critical target to preserve the functional ability that enables well-being in older age. First, we discuss the relationship between covert SVD and geriatric syndrome. SVD lesions found in non-demented, stroke-free elderly are actually not “silent” but are associated with accelerated age-related functional decline. We also review the brain structural and functional abnormalities associated with covert SVD and the possible mechanisms underlying their contributions to SVD-related cognitive and physical functional impairments. Finally, we reveal current data, though limited, on the management of elderly patients with covert SVD to prevent SVD lesion progression and functional decline. Although it is important in aging health, covert SVD is still under-recognized or misjudged by physicians in both neurological and geriatric professions. Improving the acknowledgment, detection, interpretation, and understanding of SVD would be a multidisciplinary priority to maintain cognitive and physical functions in the elderly. The dilemmas and future directions of clinical practice and research for the elderly with covert SVD are also included in the present review." @default.
- W4322154619 created "2023-02-27" @default.
- W4322154619 creator A5010804567 @default.
- W4322154619 creator A5030597935 @default.
- W4322154619 creator A5063016255 @default.
- W4322154619 creator A5086359211 @default.
- W4322154619 date "2023-07-01" @default.
- W4322154619 modified "2023-09-25" @default.
- W4322154619 title "Targeting cerebral small vessel disease to promote healthy aging: Preserving physical and cognitive functions in the elderly" @default.
- W4322154619 cites W1567524252 @default.
- W4322154619 cites W1971548649 @default.
- W4322154619 cites W1988057862 @default.
- W4322154619 cites W1994157973 @default.
- W4322154619 cites W2015010735 @default.
- W4322154619 cites W2018253362 @default.
- W4322154619 cites W2034446184 @default.
- W4322154619 cites W2038349208 @default.
- W4322154619 cites W2047316865 @default.
- W4322154619 cites W2073748140 @default.
- W4322154619 cites W2075485349 @default.
- W4322154619 cites W2084439196 @default.
- W4322154619 cites W2091163929 @default.
- W4322154619 cites W2099511111 @default.
- W4322154619 cites W2100428051 @default.
- W4322154619 cites W2109334713 @default.
- W4322154619 cites W2109527205 @default.
- W4322154619 cites W2116868098 @default.
- W4322154619 cites W2117841533 @default.
- W4322154619 cites W2120210755 @default.
- W4322154619 cites W2122294423 @default.
- W4322154619 cites W2124405724 @default.
- W4322154619 cites W2135042258 @default.
- W4322154619 cites W2140732046 @default.
- W4322154619 cites W2142227028 @default.
- W4322154619 cites W2147115476 @default.
- W4322154619 cites W2158742097 @default.
- W4322154619 cites W2164059021 @default.
- W4322154619 cites W2167945792 @default.
- W4322154619 cites W2171776652 @default.
- W4322154619 cites W2201981601 @default.
- W4322154619 cites W2292956239 @default.
- W4322154619 cites W2310054071 @default.
- W4322154619 cites W2327997790 @default.
- W4322154619 cites W2338681188 @default.
- W4322154619 cites W2364172915 @default.
- W4322154619 cites W2517883070 @default.
- W4322154619 cites W2519139027 @default.
- W4322154619 cites W2532210012 @default.
- W4322154619 cites W2588513588 @default.
- W4322154619 cites W2610536118 @default.
- W4322154619 cites W2622183425 @default.
- W4322154619 cites W2766141193 @default.
- W4322154619 cites W2773438956 @default.
- W4322154619 cites W2789556447 @default.
- W4322154619 cites W2792254568 @default.
- W4322154619 cites W2801080245 @default.
- W4322154619 cites W2804435536 @default.
- W4322154619 cites W2805830996 @default.
- W4322154619 cites W2885306996 @default.
- W4322154619 cites W2888863716 @default.
- W4322154619 cites W2889884522 @default.
- W4322154619 cites W2891412296 @default.
- W4322154619 cites W2892288854 @default.
- W4322154619 cites W2896186615 @default.
- W4322154619 cites W2898320157 @default.
- W4322154619 cites W2910684629 @default.
- W4322154619 cites W2940420923 @default.
- W4322154619 cites W2946066695 @default.
- W4322154619 cites W2947924379 @default.
- W4322154619 cites W2949150659 @default.
- W4322154619 cites W2967318538 @default.
- W4322154619 cites W2980283866 @default.
- W4322154619 cites W2990654528 @default.
- W4322154619 cites W2991513719 @default.
- W4322154619 cites W2994157969 @default.
- W4322154619 cites W2995247272 @default.
- W4322154619 cites W3005437800 @default.
- W4322154619 cites W3010328887 @default.
- W4322154619 cites W3014416510 @default.
- W4322154619 cites W3016925212 @default.
- W4322154619 cites W3023972366 @default.
- W4322154619 cites W3047157019 @default.
- W4322154619 cites W3088903441 @default.
- W4322154619 cites W3094435518 @default.
- W4322154619 cites W3095302667 @default.
- W4322154619 cites W3101125165 @default.
- W4322154619 cites W3118310327 @default.
- W4322154619 cites W3122492289 @default.
- W4322154619 cites W3135969841 @default.
- W4322154619 cites W3161563824 @default.
- W4322154619 cites W3165584042 @default.
- W4322154619 cites W3198488367 @default.
- W4322154619 cites W3210269550 @default.
- W4322154619 cites W3210314308 @default.
- W4322154619 cites W3215836782 @default.
- W4322154619 cites W4224279080 @default.
- W4322154619 cites W4225320941 @default.
- W4322154619 cites W4281615507 @default.