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• W4322487042 abstract "Abstract Compartmentalization of RNA in biopolymer-rich membraneless organelles is now understood to be pervasive and critical for the function of extant biology and has been proposed as a prebiotically-plausible way to accumulate RNA. However, compartment-RNA interactions that drive encapsulation have the potential to influence RNA structure and function in compartment- and RNA sequence-dependent ways. Herein, we detail Next-Generation Sequencing (NGS) experiments performed for the first time in membraneless compartments called complex coacervates to characterize the fold of many different transfer RNAs (tRNAs) simultaneously under the potentially denaturing conditions of these compartments. Strikingly, we find that natural modifications favor the native fold of tRNAs in these compartments. This suggests that covalent RNA modifications could have played a critical role in metabolic processes at the origin of life. One Sentence Summary We demonstrate that RNA folds into native secondary and tertiary structures in protocell models and that this is favored by covalent modifications, which is critical for the origins of life." @default.
• W4322487042 created "2023-02-28" @default.
• W4322487042 creator A5000325415 @default.
• W4322487042 creator A5031886230 @default.
• W4322487042 creator A5053201698 @default.
• W4322487042 creator A5064831960 @default.
• W4322487042 creator A5069398620 @default.
• W4322487042 date "2023-02-27" @default.
• W4322487042 modified "2023-09-30" @default.
• W4322487042 title "RNA folding studies inside peptide-rich droplets reveal roles of modified nucleosides at the origin of life" @default.
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• W4322487042 cites W1546095110 @default.
• W4322487042 cites W1912455695 @default.
• W4322487042 cites W1978583577 @default.
• W4322487042 cites W1978595049 @default.
• W4322487042 cites W1990320656 @default.
• W4322487042 cites W1995010142 @default.
• W4322487042 cites W1995143868 @default.
• W4322487042 cites W2003825614 @default.
• W4322487042 cites W2008349049 @default.
• W4322487042 cites W2012253277 @default.
• W4322487042 cites W2017934591 @default.
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• W4322487042 cites W2029483687 @default.
• W4322487042 cites W2034937344 @default.
• W4322487042 cites W2035487809 @default.
• W4322487042 cites W2036897871 @default.
• W4322487042 cites W2037577397 @default.
• W4322487042 cites W2038492487 @default.
• W4322487042 cites W2051631331 @default.
• W4322487042 cites W2053710579 @default.
• W4322487042 cites W2054249920 @default.
• W4322487042 cites W2062019095 @default.
• W4322487042 cites W2064908517 @default.
• W4322487042 cites W2065898700 @default.
• W4322487042 cites W2070820093 @default.
• W4322487042 cites W2072110058 @default.
• W4322487042 cites W2075835114 @default.
• W4322487042 cites W2076091642 @default.
• W4322487042 cites W2084694036 @default.
• W4322487042 cites W2090887754 @default.
• W4322487042 cites W2097417489 @default.
• W4322487042 cites W2104838697 @default.
• W4322487042 cites W2106039274 @default.
• W4322487042 cites W2114478647 @default.
• W4322487042 cites W2115495500 @default.
• W4322487042 cites W2120349627 @default.
• W4322487042 cites W2121287580 @default.
• W4322487042 cites W2129210977 @default.
• W4322487042 cites W2132976721 @default.
• W4322487042 cites W2136386687 @default.
• W4322487042 cites W2139170605 @default.
• W4322487042 cites W2146372535 @default.
• W4322487042 cites W2155376412 @default.
• W4322487042 cites W2155858493 @default.
• W4322487042 cites W2159192177 @default.
• W4322487042 cites W2166214695 @default.
• W4322487042 cites W2168639701 @default.
• W4322487042 cites W2223836536 @default.
• W4322487042 cites W2296979866 @default.
• W4322487042 cites W2300135289 @default.
• W4322487042 cites W2324799729 @default.
• W4322487042 cites W2408322376 @default.
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• W4322487042 cites W2467565876 @default.
• W4322487042 cites W2514582647 @default.
• W4322487042 cites W2625461439 @default.
• W4322487042 cites W2730372362 @default.
• W4322487042 cites W2767747597 @default.
• W4322487042 cites W2776559018 @default.
• W4322487042 cites W2795718064 @default.
• W4322487042 cites W2802049840 @default.
• W4322487042 cites W2883802790 @default.
• W4322487042 cites W2910568912 @default.
• W4322487042 cites W2912127110 @default.
• W4322487042 cites W2912327568 @default.
• W4322487042 cites W2948933218 @default.
• W4322487042 cites W2977849281 @default.
• W4322487042 cites W2982293539 @default.
• W4322487042 cites W2994999359 @default.
• W4322487042 cites W2999304916 @default.
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• W4322487042 cites W3133557863 @default.
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• W4322487042 doi "https://doi.org/10.1101/2023.02.27.530264" @default.
• W4322487042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36909509" @default.
• W4322487042 hasPublicationYear "2023" @default.
• W4322487042 type Work @default.
• W4322487042 citedByCount "1" @default.

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