Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322487110> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4322487110 endingPage "373" @default.
- W4322487110 startingPage "370" @default.
- W4322487110 abstract "Background The only drugs approved by the US Food and Drug Administration for oral treatment of trichomoniasis belong to the 5-nitroimidazole group. Most individuals infected with Trichomonas vaginalis can be cured with a standard treatment of metronidazole or tinidazole, but it is estimated that more than 159,000 people fail treatment each year. Although a minimal lethal concentration (MLC) corresponding to treatment failure has been reported for metronidazole, the MLC for tinidazole associated with treatment failure has not been determined. We conducted a study using T. vaginalis isolates from women with reported treatment success or failure to determine these values. Methods We measured MLCs of 47 isolates obtained from women who had failed metronidazole treatment, 33 isolates from women who had failed tinidazole treatment, and 48 isolates from women successfully cured with metronidazole. The cutoff was calculated as the 95th percentile of MLCs of susceptible isolates for each drug. Results Our data confirmed that the MLC previously associated with metronidazole treatment failure is ≥50 μg/mL and identified the MLC associated with tinidazole treatment failure as ≥6.3 μg/mL. For metronidazole, the agreement between laboratory result and treatment outcome was 93.7%; for tinidazole, this agreement was 88.9%. Conclusions The T. vaginalis susceptibility assay is useful for determining whether 5-nitroimidazole treatment failure in persons with trichomoniasis can be attributed to drug resistance. These results are useful for establishing interpretive guidance of test results, and MLC levels can help guide appropriate patient treatment." @default.
- W4322487110 created "2023-02-28" @default.
- W4322487110 creator A5032005732 @default.
- W4322487110 creator A5040905123 @default.
- W4322487110 creator A5075986818 @default.
- W4322487110 creator A5076715795 @default.
- W4322487110 date "2023-03-24" @default.
- W4322487110 modified "2023-10-01" @default.
- W4322487110 title "In Vitro Testing of Trichomonas vaginalis Drug Susceptibility: Evaluation of Minimal Lethal Concentrations for Metronidazole and Tinidazole That Correspond With Treatment Failure" @default.
- W4322487110 cites W1964506433 @default.
- W4322487110 cites W1969499296 @default.
- W4322487110 cites W1975910922 @default.
- W4322487110 cites W1979439261 @default.
- W4322487110 cites W1988128159 @default.
- W4322487110 cites W2047478018 @default.
- W4322487110 cites W2064389088 @default.
- W4322487110 cites W2078495656 @default.
- W4322487110 cites W2102824635 @default.
- W4322487110 cites W2109981777 @default.
- W4322487110 cites W2145845923 @default.
- W4322487110 cites W2169756226 @default.
- W4322487110 cites W2587942285 @default.
- W4322487110 cites W2790614158 @default.
- W4322487110 cites W2885184145 @default.
- W4322487110 cites W2898005124 @default.
- W4322487110 cites W2963541510 @default.
- W4322487110 cites W3046690023 @default.
- W4322487110 cites W3122088738 @default.
- W4322487110 cites W3135312591 @default.
- W4322487110 cites W3164325962 @default.
- W4322487110 cites W3164421300 @default.
- W4322487110 cites W4210968944 @default.
- W4322487110 doi "https://doi.org/10.1097/olq.0000000000001788" @default.
- W4322487110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36849257" @default.
- W4322487110 hasPublicationYear "2023" @default.
- W4322487110 type Work @default.
- W4322487110 citedByCount "1" @default.
- W4322487110 countsByYear W43224871102023 @default.
- W4322487110 crossrefType "journal-article" @default.
- W4322487110 hasAuthorship W4322487110A5032005732 @default.
- W4322487110 hasAuthorship W4322487110A5040905123 @default.
- W4322487110 hasAuthorship W4322487110A5075986818 @default.
- W4322487110 hasAuthorship W4322487110A5076715795 @default.
- W4322487110 hasBestOaLocation W43224871101 @default.
- W4322487110 hasConcept C114851261 @default.
- W4322487110 hasConcept C126322002 @default.
- W4322487110 hasConcept C142724271 @default.
- W4322487110 hasConcept C2777023796 @default.
- W4322487110 hasConcept C2777396551 @default.
- W4322487110 hasConcept C2780035454 @default.
- W4322487110 hasConcept C2780626017 @default.
- W4322487110 hasConcept C2781047020 @default.
- W4322487110 hasConcept C2781114625 @default.
- W4322487110 hasConcept C29456083 @default.
- W4322487110 hasConcept C501593827 @default.
- W4322487110 hasConcept C71924100 @default.
- W4322487110 hasConcept C86803240 @default.
- W4322487110 hasConcept C89423630 @default.
- W4322487110 hasConcept C90924648 @default.
- W4322487110 hasConcept C98274493 @default.
- W4322487110 hasConceptScore W4322487110C114851261 @default.
- W4322487110 hasConceptScore W4322487110C126322002 @default.
- W4322487110 hasConceptScore W4322487110C142724271 @default.
- W4322487110 hasConceptScore W4322487110C2777023796 @default.
- W4322487110 hasConceptScore W4322487110C2777396551 @default.
- W4322487110 hasConceptScore W4322487110C2780035454 @default.
- W4322487110 hasConceptScore W4322487110C2780626017 @default.
- W4322487110 hasConceptScore W4322487110C2781047020 @default.
- W4322487110 hasConceptScore W4322487110C2781114625 @default.
- W4322487110 hasConceptScore W4322487110C29456083 @default.
- W4322487110 hasConceptScore W4322487110C501593827 @default.
- W4322487110 hasConceptScore W4322487110C71924100 @default.
- W4322487110 hasConceptScore W4322487110C86803240 @default.
- W4322487110 hasConceptScore W4322487110C89423630 @default.
- W4322487110 hasConceptScore W4322487110C90924648 @default.
- W4322487110 hasConceptScore W4322487110C98274493 @default.
- W4322487110 hasIssue "6" @default.
- W4322487110 hasLocation W43224871101 @default.
- W4322487110 hasLocation W43224871102 @default.
- W4322487110 hasLocation W43224871103 @default.
- W4322487110 hasLocation W43224871104 @default.
- W4322487110 hasOpenAccess W4322487110 @default.
- W4322487110 hasPrimaryLocation W43224871101 @default.
- W4322487110 hasRelatedWork W131983924 @default.
- W4322487110 hasRelatedWork W1964506433 @default.
- W4322487110 hasRelatedWork W2100194553 @default.
- W4322487110 hasRelatedWork W2109981777 @default.
- W4322487110 hasRelatedWork W2218687910 @default.
- W4322487110 hasRelatedWork W2738619617 @default.
- W4322487110 hasRelatedWork W4282918499 @default.
- W4322487110 hasRelatedWork W4318933965 @default.
- W4322487110 hasRelatedWork W4322487110 @default.
- W4322487110 hasRelatedWork W5576171 @default.
- W4322487110 hasVolume "50" @default.
- W4322487110 isParatext "false" @default.
- W4322487110 isRetracted "false" @default.
- W4322487110 workType "article" @default.