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- W4322490231 endingPage "e202201804" @default.
- W4322490231 startingPage "e202201804" @default.
- W4322490231 abstract "The leukotriene (LT) pathway is positively correlated with the progression of solid malignancies, but the factors that control the expression of 5-lipoxygenase (5-LO), the central enzyme in LT biosynthesis, in tumors are poorly understood. Here, we report that 5-LO along with other members of the LT pathway is up-regulated in multicellular colon tumor spheroids. This up-regulation was inversely correlated with cell proliferation and activation of PI3K/mTORC-2- and MEK-1/ERK-dependent pathways. Furthermore, we found that E2F1 and its target gene MYBL2 were involved in the repression of 5-LO during cell proliferation. Importantly, we found that this PI3K/mTORC-2- and MEK-1/ERK-dependent suppression of 5-LO is also existent in tumor cells from other origins, suggesting that this mechanism is widely applicable to other tumor entities. Our data show that tumor cells fine-tune 5-LO and LT biosynthesis in response to environmental changes repressing the enzyme during proliferation while making use of the enzyme under cell stress conditions, implying that tumor-derived 5-LO plays a role in the manipulation of the tumor stroma to quickly restore cell proliferation." @default.
- W4322490231 created "2023-02-28" @default.
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- W4322490231 date "2023-02-27" @default.
- W4322490231 modified "2023-09-27" @default.
- W4322490231 title "Three-dimensional growth reveals fine-tuning of 5-lipoxygenase by proliferative pathways in cancer" @default.
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- W4322490231 doi "https://doi.org/10.26508/lsa.202201804" @default.
- W4322490231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36849252" @default.
- W4322490231 hasPublicationYear "2023" @default.
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