Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322490302> ?p ?o ?g. }
- W4322490302 abstract "A challenge for screening new candidate drugs to treat cancer is that efficacy in cell culture models is not always predictive of efficacy in patients. One limitation of standard cell culture is a reliance on non-physiological nutrient levels to propagate cells. Which nutrients are available can influence how cancer cells use metabolism to proliferate and impact sensitivity to some drugs, but a general assessment of how physiological nutrients affect cancer cell response to small molecule therapies is lacking. To enable screening of compounds to determine how the nutrient environment impacts drug efficacy, we developed a serum-derived culture medium that supports the proliferation of diverse cancer cell lines and is amenable to high-throughput screening. We used this system to screen several small molecule libraries and found that compounds targeting metabolic enzymes were enriched as having differential efficacy in standard compared to serum-derived medium. We exploited the differences in nutrient levels between each medium to understand why medium conditions affected the response of cells to some compounds, illustrating how this approach can be used to screen potential therapeutics and understand how their efficacy is modified by available nutrients." @default.
- W4322490302 created "2023-02-28" @default.
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- W4322490302 date "2023-02-27" @default.
- W4322490302 modified "2023-10-18" @default.
- W4322490302 title "Screening in serum-derived medium reveals differential response to compounds targeting metabolism" @default.
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- W4322490302 cites W2104696999 @default.
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- W4322490302 cites W2530859476 @default.
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- W4322490302 cites W2586265133 @default.
- W4322490302 cites W2604353006 @default.
- W4322490302 cites W2606822414 @default.
- W4322490302 cites W2726164542 @default.
- W4322490302 cites W2727828415 @default.
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- W4322490302 cites W2759290374 @default.
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- W4322490302 cites W2808976292 @default.
- W4322490302 cites W2891318902 @default.
- W4322490302 cites W2906906692 @default.
- W4322490302 cites W2916822920 @default.
- W4322490302 cites W2950983102 @default.
- W4322490302 cites W2974335854 @default.
- W4322490302 cites W2980028148 @default.
- W4322490302 cites W3013554928 @default.
- W4322490302 cites W3041700018 @default.
- W4322490302 cites W3043969900 @default.
- W4322490302 cites W3109957234 @default.
- W4322490302 cites W3123922203 @default.
- W4322490302 cites W3133635220 @default.
- W4322490302 cites W3168590102 @default.
- W4322490302 cites W3205872415 @default.
- W4322490302 cites W3214041919 @default.
- W4322490302 cites W3214360707 @default.
- W4322490302 cites W4206447491 @default.
- W4322490302 cites W4226141710 @default.
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- W4322490302 doi "https://doi.org/10.1101/2023.02.25.529972" @default.
- W4322490302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36909640" @default.
- W4322490302 hasPublicationYear "2023" @default.