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• W4322493073 abstract "AbstractBackground Allergic rhinitis (AR) is a great risk factor for developing asthma, and its pathogenesis is affected by various factors, such as gene and environment. GSDMB is related to allergic diseases. Our purpose is to explore the correlation of single nucleotide polymorphisms (SNPs) in GSDMB and AR risk in the Chinese population.Methods We performed a case-control study including 1005 cases and 1004 controls. Rs2305479, rs4795400, and rs12450091 in GSDMB were geneotyped using Agena MassARRAY. The relationships between GSDMB SNPs and AR risk were assessed by logistic regression analysis in PLINK1.9.Results Our study showed that rs4795400 was a protective factor for AR in overall (TT vs. CC: OR = 0.66, p = 0.009; TT vs. CC/TC: OR = 0.67, p = 0.008; additive: OR = 0.87, p = 0.042 males, people with BMI ≤ 24, and living in wind-blown sand area. Rs2305479 was associated with a reduced AR risk in males (TT vs. CC: OR = 0.47, p = 0.014; TT vs. CC/TC: OR = 0.43, p = 0.004). However, rs12450091 was a risk factor for AR in people living in the loess hilly region (CC: OR = 4.75, p = 0.047). The levels of EO and EO_per in the case group were significantly higher than those in the control group (p < 0.05).Conclusion This study indicated that GSDMB polymorphisms (rs4795400, rs2305479, and rs12450091) were associated with AR susceptibility. Further studies are required to confirm our findings and to clarify the functional relationship.Keywords: Chinese populationallergic rhinitisGSDMBsingle nucleotide polymorphisms Declaration of interestThe authors declare no conflict of interest.Ethics standard statementThis study approved by the ethics committee of Shenmu hospital, and all experimental methods were strictly in compliance with the 1964 Helsinki Declaration. Each participant completed an informed consent form after learning about the study objectives.Additional informationFundingThis work was supported by Natural Science Foundation of Shanxi Province (2021SF-075), Science and Technology Plan Project of Yulin City (YF-2020–191), and Shenmu Municipal Government Scientific Research Project (2019) No. 5." @default.
• W4322493073 created "2023-02-28" @default.
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• W4322493073 date "2023-03-21" @default.
• W4322493073 modified "2023-10-17" @default.
• W4322493073 title "Association between polymorphisms of the <i>GSDMB</i> gene and allergic rhinitis risk in the Chinese population: a case-control study" @default.
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• W4322493073 doi "https://doi.org/10.1080/02770903.2023.2185893" @default.
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