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• W4322501294 endingPage "624" @default.
• W4322501294 startingPage "624" @default.
• W4322501294 abstract "SARS-CoV-2 has caused the COVID-19 pandemic, with over 673 million infections and 6.85 million deaths globally. Novel mRNA and viral-vectored vaccines were developed and licensed for global immunizations under emergency approval. They have demonstrated good safety and high protective efficacy against the SARS-CoV-2 Wuhan strain. However, the emergence of highly infectious and transmissible variants of concern (VOCs) such as Omicron was associated with considerable reductions in the protective efficacy of the current vaccines. The development of next-generation vaccines that could confer broad protection against both the SARS-CoV-2 Wuhan strain and VOCs is urgently needed. A bivalent mRNA vaccine encoding the Spike proteins of both the SARS-CoV-2 Wuhan strain and the Omicron variant has been constructed and approved by the US FDA. However, mRNA vaccines are associated with instability and require an extremely low temperature (-80 °C) for storage and transportation. They also require complex synthesis and multiple chromatographic purifications. Peptide-based next-generation vaccines could be developed by relying on in silico predictions to identify peptides specifying highly conserved B, CD4+ and CD8+ T cell epitopes to elicit broad and long-lasting immune protection. These epitopes were validated in animal models and in early phase clinical trials to demonstrate immunogenicity and safety. Next-generation peptide vaccine formulations could be developed to incorporate only naked peptides, but they are costly to synthesize and production would generate extensive chemical waste. Continual production of recombinant peptides specifying immunogenic B and T cell epitopes could be achieved in hosts such as E. coli or yeast. However, recombinant protein/peptide vaccines require purification before administration. The DNA vaccine might serve as the most effective next-generation vaccine for low-income countries, since it does not require an extremely low temperature for storage or need extensive chromatographic purification. The construction of recombinant plasmids carrying genes specifying highly conserved B and T cell epitopes meant that vaccine candidates representing highly conserved antigenic regions could be rapidly developed. Poor immunogenicity of DNA vaccines could be overcome by the incorporation of chemical or molecular adjuvants and the development of nanoparticles for effective delivery." @default.
• W4322501294 created "2023-02-28" @default.
• W4322501294 creator A5031883144 @default.
• W4322501294 creator A5035001977 @default.
• W4322501294 creator A5035976765 @default.
• W4322501294 creator A5056576319 @default.
• W4322501294 date "2023-02-24" @default.
• W4322501294 modified "2023-10-05" @default.
• W4322501294 title "Development of Next Generation Vaccines against SARS-CoV-2 and Variants of Concern" @default.
• W4322501294 cites W1963781218 @default.
• W4322501294 cites W1968806769 @default.
• W4322501294 cites W2001674944 @default.
• W4322501294 cites W2900898034 @default.
• W4322501294 cites W2942484034 @default.
• W4322501294 cites W3027138240 @default.
• W4322501294 cites W3039901154 @default.
• W4322501294 cites W3084653951 @default.
• W4322501294 cites W3087924281 @default.
• W4322501294 cites W3106595452 @default.
• W4322501294 cites W3107112434 @default.
• W4322501294 cites W3108218756 @default.
• W4322501294 cites W3112028440 @default.
• W4322501294 cites W3119345685 @default.
• W4322501294 cites W3130509966 @default.
• W4322501294 cites W3133277826 @default.
• W4322501294 cites W3133794453 @default.
• W4322501294 cites W3135383916 @default.
• W4322501294 cites W3135956842 @default.
• W4322501294 cites W3139074260 @default.
• W4322501294 cites W3141854134 @default.
• W4322501294 cites W3142193311 @default.
• W4322501294 cites W3152102956 @default.
• W4322501294 cites W3159452464 @default.
• W4322501294 cites W3164513349 @default.
• W4322501294 cites W3165265659 @default.
• W4322501294 cites W3165479483 @default.
• W4322501294 cites W3165872417 @default.
• W4322501294 cites W3167632857 @default.
• W4322501294 cites W3169942726 @default.
• W4322501294 cites W3169972518 @default.
• W4322501294 cites W3172858351 @default.
• W4322501294 cites W3173951993 @default.
• W4322501294 cites W3175923549 @default.
• W4322501294 cites W3183388359 @default.
• W4322501294 cites W3184287782 @default.
• W4322501294 cites W3185503435 @default.
• W4322501294 cites W3187307462 @default.
• W4322501294 cites W3192313478 @default.
• W4322501294 cites W3192691285 @default.
• W4322501294 cites W3193682077 @default.
• W4322501294 cites W3196745706 @default.
• W4322501294 cites W3197259637 @default.
• W4322501294 cites W3199731605 @default.
• W4322501294 cites W3202026753 @default.
• W4322501294 cites W3204497138 @default.
• W4322501294 cites W3206756402 @default.
• W4322501294 cites W3209117690 @default.
• W4322501294 cites W3210781576 @default.
• W4322501294 cites W3212394553 @default.
• W4322501294 cites W3214843790 @default.
• W4322501294 cites W3215049942 @default.
• W4322501294 cites W3216348181 @default.
• W4322501294 cites W3217313168 @default.
• W4322501294 cites W4200047841 @default.
• W4322501294 cites W4200352634 @default.
• W4322501294 cites W4200469507 @default.
• W4322501294 cites W4205584890 @default.
• W4322501294 cites W4206495469 @default.
• W4322501294 cites W4206782835 @default.
• W4322501294 cites W4206961663 @default.
• W4322501294 cites W4207077414 @default.
• W4322501294 cites W4210667549 @default.
• W4322501294 cites W4212880839 @default.
• W4322501294 cites W4213440258 @default.
• W4322501294 cites W4220680697 @default.
• W4322501294 cites W4220807057 @default.
• W4322501294 cites W4221015497 @default.
• W4322501294 cites W4223559662 @default.
• W4322501294 cites W4224039484 @default.
• W4322501294 cites W4224211113 @default.
• W4322501294 cites W4224289523 @default.
• W4322501294 cites W4224321626 @default.
• W4322501294 cites W4224992781 @default.
• W4322501294 cites W4226102343 @default.
• W4322501294 cites W4280594901 @default.
• W4322501294 cites W4281678900 @default.
• W4322501294 cites W4281890729 @default.
• W4322501294 cites W4283157316 @default.
• W4322501294 cites W4283320603 @default.
• W4322501294 cites W4283721263 @default.
• W4322501294 cites W4285012054 @default.
• W4322501294 cites W4285506507 @default.
• W4322501294 cites W4285727132 @default.
• W4322501294 cites W4285797779 @default.
• W4322501294 cites W4294071873 @default.
• W4322501294 cites W4295709321 @default.
• W4322501294 cites W4303575407 @default.
• W4322501294 cites W4306874674 @default.

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