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- W4322501748 abstract "Since its introduction in 2007 in Europe and in 2017 in the United States, 5-ALA has demonstrated an undisputed advantage in providing real-time tumor visualization. The aim of the present paper is to summarize our institutional experience over a decade of routine 5-ALA-guided procedures in order to provide five surgical tricks to ease surgical workflow.Data were collected from 822 patients diagnosed with histopathologically confirmed high-grade gliomas (HGG)-according to the WHO 2021 criteria-who underwent surgery at the Fondazione Policlinico Universitario Agostino Gemelli between January 2012 and January 2022.From our large institutional experience, the learned technical pearls were grouped in five distinct domains: 1. Analysis of visualization, overall workflow, and technical recommendations to improve intraoperative set-up; 2. Techniques to reduce the risk of inadvertent residuals and failure to evocate fluorescence; 3. Analysis of specific surgical conditions favoring remnants; 4. Assessment of different degrees of fluorescence and their surgical meaning; 5. Analysis of false positive cases.With all the limitations of a qualitative and retrospective analysis, this paper was specifically conceived as a vademecum for educational purposes to promote and maximize 5-ALA employment." @default.
- W4322501748 created "2023-02-28" @default.
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- W4322501748 date "2023-02-27" @default.
- W4322501748 modified "2023-09-30" @default.
- W4322501748 title "Technical Pearls to Effectively Use 5-ALA in Fluorescence-Guided Tumor Resection—5 Lessons from the Operating Room" @default.
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- W4322501748 doi "https://doi.org/10.3390/brainsci13030411" @default.
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