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- W4322576238 abstract "Sepsis can cause lung injury. Prior to the COVID-19 pandemic, sepsis was the main cause of acute respiratory distress syndrome (ARDS), associated with approximately >50% of cases. Mechanical ventilation (MV) may amplify the lung-specific inflammatory response in preinjured lungs by elevating cytokine release and augmenting damage to the alveolar integrity; in addition, sepsis per se constitutes a risk factor for mechanical ventilator-induced lung injury. Inadequate ventilator setting can contribute to increased infection-induced organ failure and uncontrolled systemic inflammatory response. Objectives of invasive MV are to maintain adequate gas exchange: maintain oxygenation goals and adequate ventilation. Regarding ventilatory modes, it has been proposed that volume control-continuous mandatory ventilation may be more protective than pressure control-continuous mandatory ventilation. It may be reasonable to maintain a target arterial partial pressure of oxygen of 60–80 mm Hg (Young et al. 2022) or a saturation of peripheral oxygen of 92%–96% for most patients. Sepsis-induced diaphragmatic dysfunction is a major risk factor of weaning failure during MV. Diaphragmatic ultrasound had been a useful tool for predicting successful liberation from MV. Another important aspect of ventilation is the type of sedation to use." @default.
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- W4322576238 date "2023-01-01" @default.
- W4322576238 modified "2023-10-16" @default.
- W4322576238 title "Mechanical Ventilation in Sepsis" @default.
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- W4322576238 doi "https://doi.org/10.1016/b978-0-323-88271-2.00009-2" @default.
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