Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322582051> ?p ?o ?g. }
- W4322582051 endingPage "014301" @default.
- W4322582051 startingPage "014301" @default.
- W4322582051 abstract "Biological life depends on motion, and this manifests itself in proteins that display motion over a formidable range of time scales spanning from femtoseconds vibrations of atoms at enzymatic transition states, all the way to slow domain motions occurring on micro to milliseconds. An outstanding challenge in contemporary biophysics and structural biology is a quantitative understanding of the linkages among protein structure, dynamics, and function. These linkages are becoming increasingly explorable due to conceptual and methodological advances. In this Perspective article, we will point toward future directions of the field of protein dynamics with an emphasis on enzymes. Research questions in the field are becoming increasingly complex such as the mechanistic understanding of high-order interaction networks in allosteric signal propagation through a protein matrix, or the connection between local and collective motions. In analogy to the solution to the “protein folding problem,” we argue that the way forward to understanding these and other important questions lies in the successful integration of experiment and computation, while utilizing the present rapid expansion of sequence and structure space. Looking forward, the future is bright, and we are in a period where we are on the doorstep to, at least in part, comprehend the importance of dynamics for biological function." @default.
- W4322582051 created "2023-02-28" @default.
- W4322582051 creator A5022993160 @default.
- W4322582051 creator A5073296084 @default.
- W4322582051 date "2023-01-01" @default.
- W4322582051 modified "2023-10-14" @default.
- W4322582051 title "Protein dynamics: The future is bright and complicated!" @default.
- W4322582051 cites W1563420247 @default.
- W4322582051 cites W1631384180 @default.
- W4322582051 cites W1939911045 @default.
- W4322582051 cites W1963510575 @default.
- W4322582051 cites W1965093499 @default.
- W4322582051 cites W1968127704 @default.
- W4322582051 cites W1968910000 @default.
- W4322582051 cites W1972607828 @default.
- W4322582051 cites W1974093948 @default.
- W4322582051 cites W1974225312 @default.
- W4322582051 cites W1976528962 @default.
- W4322582051 cites W1980274652 @default.
- W4322582051 cites W1980397617 @default.
- W4322582051 cites W1980871893 @default.
- W4322582051 cites W1985854865 @default.
- W4322582051 cites W1997477098 @default.
- W4322582051 cites W1998093640 @default.
- W4322582051 cites W1998385377 @default.
- W4322582051 cites W2000870489 @default.
- W4322582051 cites W2001746030 @default.
- W4322582051 cites W2005087735 @default.
- W4322582051 cites W2008609697 @default.
- W4322582051 cites W2010004274 @default.
- W4322582051 cites W2010867867 @default.
- W4322582051 cites W2013593586 @default.
- W4322582051 cites W2014425795 @default.
- W4322582051 cites W2024872256 @default.
- W4322582051 cites W2025587541 @default.
- W4322582051 cites W2028968631 @default.
- W4322582051 cites W2045777307 @default.
- W4322582051 cites W2046002103 @default.
- W4322582051 cites W2048822589 @default.
- W4322582051 cites W2052246375 @default.
- W4322582051 cites W2055214702 @default.
- W4322582051 cites W2055497972 @default.
- W4322582051 cites W2060256690 @default.
- W4322582051 cites W2067236515 @default.
- W4322582051 cites W2083144176 @default.
- W4322582051 cites W2088437224 @default.
- W4322582051 cites W2088838131 @default.
- W4322582051 cites W2089597488 @default.
- W4322582051 cites W2098787719 @default.
- W4322582051 cites W2101868444 @default.
- W4322582051 cites W2111500681 @default.
- W4322582051 cites W2118493964 @default.
- W4322582051 cites W2121627241 @default.
- W4322582051 cites W2126466006 @default.
- W4322582051 cites W2127362915 @default.
- W4322582051 cites W2127433893 @default.
- W4322582051 cites W2128722373 @default.
- W4322582051 cites W2134742468 @default.
- W4322582051 cites W2141838908 @default.
- W4322582051 cites W2147850116 @default.
- W4322582051 cites W2149744037 @default.
- W4322582051 cites W2150378237 @default.
- W4322582051 cites W2151030977 @default.
- W4322582051 cites W2155748850 @default.
- W4322582051 cites W2185488647 @default.
- W4322582051 cites W2252883583 @default.
- W4322582051 cites W2311509164 @default.
- W4322582051 cites W2472055225 @default.
- W4322582051 cites W2507479832 @default.
- W4322582051 cites W2511991795 @default.
- W4322582051 cites W2512259981 @default.
- W4322582051 cites W2516828306 @default.
- W4322582051 cites W2522558972 @default.
- W4322582051 cites W2578958622 @default.
- W4322582051 cites W2586486617 @default.
- W4322582051 cites W2597938361 @default.
- W4322582051 cites W2609912642 @default.
- W4322582051 cites W2617426780 @default.
- W4322582051 cites W2748712299 @default.
- W4322582051 cites W2761947594 @default.
- W4322582051 cites W2769965731 @default.
- W4322582051 cites W2788194767 @default.
- W4322582051 cites W2804043881 @default.
- W4322582051 cites W2887892148 @default.
- W4322582051 cites W2892129768 @default.
- W4322582051 cites W2949706399 @default.
- W4322582051 cites W2963487095 @default.
- W4322582051 cites W2963680108 @default.
- W4322582051 cites W3014987177 @default.
- W4322582051 cites W3015289636 @default.
- W4322582051 cites W3031273907 @default.
- W4322582051 cites W3036620924 @default.
- W4322582051 cites W3048186176 @default.
- W4322582051 cites W3080100106 @default.
- W4322582051 cites W3080779913 @default.
- W4322582051 cites W3084236163 @default.
- W4322582051 cites W3089408272 @default.
- W4322582051 cites W3093331104 @default.