FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322616804> ?p ?o ?g. }

• W4322616804 endingPage "3415" @default.
• W4322616804 startingPage "3404" @default.
• W4322616804 abstract "Focal cortical dysplasia (FCD) type II is a highly epileptogenic developmental malformation and a common cause of surgically treated drug-resistant epilepsy. While clinical observations suggest frequent occurrence in the frontal lobe, mechanisms for such propensity remain unexplored. Here, we hypothesized that cortex-wide spatial associations of FCD distribution with cortical cytoarchitecture, gene expression and organizational axes may offer complementary insights into processes that predispose given cortical regions to harbour FCD. We mapped the cortex-wide MRI distribution of FCDs in 337 patients collected from 13 sites worldwide. We then determined its associations with (i) cytoarchitectural features using histological atlases by Von Economo and Koskinas and BigBrain; (ii) whole-brain gene expression and spatiotemporal dynamics from prenatal to adulthood stages using the Allen Human Brain Atlas and PsychENCODE BrainSpan; and (iii) macroscale developmental axes of cortical organization. FCD lesions were preferentially located in the prefrontal and fronto-limbic cortices typified by low neuron density, large soma and thick grey matter. Transcriptomic associations with FCD distribution uncovered a prenatal component related to neuroglial proliferation and differentiation, likely accounting for the dysplastic makeup, and a postnatal component related to synaptogenesis and circuit organization, possibly contributing to circuit-level hyperexcitability. FCD distribution showed a strong association with the anterior region of the antero-posterior axis derived from heritability analysis of interregional structural covariance of cortical thickness, but not with structural and functional hierarchical axes. Reliability of all results was confirmed through resampling techniques. Multimodal associations with cytoarchitecture, gene expression and axes of cortical organization indicate that prenatal neurogenesis and postnatal synaptogenesis may be key points of developmental vulnerability of the frontal lobe to FCD. Concordant with a causal role of atypical neuroglial proliferation and growth, our results indicate that FCD-vulnerable cortices display properties indicative of earlier termination of neurogenesis and initiation of cell growth. They also suggest a potential contribution of aberrant postnatal synaptogenesis and circuit development to FCD epileptogenicity." @default.
• W4322616804 created "2023-03-01" @default.
• W4322616804 creator A5002190177 @default.
• W4322616804 creator A5005096130 @default.
• W4322616804 creator A5005755344 @default.
• W4322616804 creator A5009709929 @default.
• W4322616804 creator A5009870571 @default.
• W4322616804 creator A5011890517 @default.
• W4322616804 creator A5013301045 @default.
• W4322616804 creator A5023036783 @default.
• W4322616804 creator A5026728473 @default.
• W4322616804 creator A5028374451 @default.
• W4322616804 creator A5035326417 @default.
• W4322616804 creator A5040180003 @default.
• W4322616804 creator A5044809264 @default.
• W4322616804 creator A5053193830 @default.
• W4322616804 creator A5070848254 @default.
• W4322616804 creator A5073875594 @default.
• W4322616804 creator A5074816207 @default.
• W4322616804 creator A5075090194 @default.
• W4322616804 creator A5077690362 @default.
• W4322616804 creator A5077774398 @default.
• W4322616804 creator A5083765806 @default.
• W4322616804 creator A5083945779 @default.
• W4322616804 creator A5084835401 @default.
• W4322616804 creator A5091400465 @default.
• W4322616804 date "2023-02-28" @default.
• W4322616804 modified "2023-10-17" @default.
• W4322616804 title "Multimodal mapping of regional brain vulnerability to focal cortical dysplasia" @default.
• W4322616804 cites W1483653355 @default.
• W4322616804 cites W1837238719 @default.
• W4322616804 cites W1896089105 @default.
• W4322616804 cites W1900267874 @default.
• W4322616804 cites W1939528805 @default.
• W4322616804 cites W1963806203 @default.
• W4322616804 cites W1968931043 @default.
• W4322616804 cites W1969085791 @default.
• W4322616804 cites W1973319971 @default.
• W4322616804 cites W1987182404 @default.
• W4322616804 cites W1990300831 @default.
• W4322616804 cites W1998859476 @default.
• W4322616804 cites W2008357135 @default.
• W4322616804 cites W2011842664 @default.
• W4322616804 cites W2018667441 @default.
• W4322616804 cites W2019715927 @default.
• W4322616804 cites W2022689242 @default.
• W4322616804 cites W2029923284 @default.
• W4322616804 cites W2035282286 @default.
• W4322616804 cites W2037192432 @default.
• W4322616804 cites W2038933710 @default.
• W4322616804 cites W2046683077 @default.
• W4322616804 cites W2055655674 @default.
• W4322616804 cites W2058046532 @default.
• W4322616804 cites W2059707668 @default.
• W4322616804 cites W2060290761 @default.
• W4322616804 cites W2066096950 @default.
• W4322616804 cites W2068943457 @default.
• W4322616804 cites W2072499064 @default.
• W4322616804 cites W2079980086 @default.
• W4322616804 cites W2080591926 @default.
• W4322616804 cites W2084459267 @default.
• W4322616804 cites W2086686257 @default.
• W4322616804 cites W2099726665 @default.
• W4322616804 cites W2101135654 @default.
• W4322616804 cites W2105549490 @default.
• W4322616804 cites W2105727230 @default.
• W4322616804 cites W2107836788 @default.
• W4322616804 cites W2111043432 @default.
• W4322616804 cites W2120282622 @default.
• W4322616804 cites W2121539587 @default.
• W4322616804 cites W2131339155 @default.
• W4322616804 cites W2148601705 @default.
• W4322616804 cites W2152748843 @default.
• W4322616804 cites W2153614880 @default.
• W4322616804 cites W2155740914 @default.
• W4322616804 cites W2157617631 @default.
• W4322616804 cites W2159289472 @default.
• W4322616804 cites W2161493176 @default.
• W4322616804 cites W2162500823 @default.
• W4322616804 cites W2215436807 @default.
• W4322616804 cites W2260830658 @default.
• W4322616804 cites W2266968689 @default.
• W4322616804 cites W2268666612 @default.
• W4322616804 cites W2268902789 @default.
• W4322616804 cites W2331575464 @default.
• W4322616804 cites W2411308809 @default.
• W4322616804 cites W2497939844 @default.
• W4322616804 cites W2536956629 @default.
• W4322616804 cites W2542664757 @default.
• W4322616804 cites W2567586580 @default.
• W4322616804 cites W2580798480 @default.
• W4322616804 cites W2582025421 @default.
• W4322616804 cites W2588142332 @default.
• W4322616804 cites W2766867032 @default.
• W4322616804 cites W2773293192 @default.
• W4322616804 cites W2777756804 @default.
• W4322616804 cites W2790570242 @default.
• W4322616804 cites W2793783592 @default.

• next