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- W4322619541 startingPage "17" @default.
- W4322619541 abstract "The partial remission (PR) phase of type 1 diabetes (T1D) is an underexplored period characterized by endogenous insulin production and downmodulated autoimmunity. To comprehend the mechanisms behind this transitory phase and develop precision medicine strategies, biomarker discovery and patient stratification are unmet needs. MicroRNAs (miRNAs) are small RNA molecules that negatively regulate gene expression and modulate several biological processes, functioning as biomarkers for many diseases. Here, we identify and validate a unique miRNA signature during PR in pediatric patients with T1D by employing small RNA sequencing and RT-qPCR. These miRNAs were mainly related to the immune system, metabolism, stress, and apoptosis pathways. The implication in autoimmunity of the most dysregulated miRNA, miR-30d-5p, was evaluated in vivo in the non-obese diabetic mouse. MiR-30d-5p inhibition resulted in increased regulatory T cell percentages in the pancreatic lymph nodes together with a higher expression of CD200. In the spleen, a decrease in PD-1+ T lymphocytes and reduced PDCD1 expression were observed. Moreover, miR-30d-5p inhibition led to an increased islet leukocytic infiltrate and changes in both effector and memory T lymphocytes. In conclusion, the miRNA signature found during PR shows new putative biomarkers and highlights the immunomodulatory role of miR-30d-5p, elucidating the processes driving this phase." @default.
- W4322619541 created "2023-03-01" @default.
- W4322619541 creator A5007893238 @default.
- W4322619541 creator A5008950634 @default.
- W4322619541 creator A5016083477 @default.
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- W4322619541 creator A5083265378 @default.
- W4322619541 creator A5085717859 @default.
- W4322619541 creator A5089283689 @default.
- W4322619541 date "2023-02-28" @default.
- W4322619541 modified "2023-10-08" @default.
- W4322619541 title "Immunoregulatory Biomarkers of the Remission Phase in Type 1 Diabetes: miR-30d-5p Modulates PD-1 Expression and Regulatory T Cell Expansion" @default.
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- W4322619541 doi "https://doi.org/10.3390/ncrna9020017" @default.