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- W4322619881 abstract "cAMP is a second messenger that regulates a myriad of cellular functions in response to multiple extracellular stimuli. New developments in the field have provided exciting insights into how cAMP utilizes compartmentalization to ensure specificity when the message conveyed to the cell by an extracellular stimulus is translated into the appropriate functional outcome. cAMP compartmentalization relies on the formation of local signaling domains where the subset of cAMP signaling effectors, regulators and targets involved in a specific cellular response cluster together. These domains are dynamic in nature and underpin the exacting spatiotemporal regulation of cAMP signaling. In this review, we focus on how the proteomics toolbox can be utilized to identify the molecular components of these domains and to define the dynamic cellular cAMP signaling landscape. From a therapeutic perspective, compiling data on compartmentalized cAMP signaling in physiological and pathological conditions will help define the signaling events underlying disease and may reveal domain-specific targets for the development of precision medicine interventions." @default.
- W4322619881 created "2023-03-01" @default.
- W4322619881 creator A5003664415 @default.
- W4322619881 creator A5030709777 @default.
- W4322619881 creator A5043602547 @default.
- W4322619881 date "2023-02-28" @default.
- W4322619881 modified "2023-10-14" @default.
- W4322619881 title "Using the Proteomics Toolbox to Resolve Topology and Dynamics of Compartmentalized cAMP Signaling" @default.
- W4322619881 cites W1500288237 @default.
- W4322619881 cites W1595835172 @default.
- W4322619881 cites W1948425938 @default.
- W4322619881 cites W1964332360 @default.
- W4322619881 cites W1968063944 @default.
- W4322619881 cites W1972029787 @default.
- W4322619881 cites W1980496079 @default.
- W4322619881 cites W1981153918 @default.
- W4322619881 cites W1981251596 @default.
- W4322619881 cites W1986015398 @default.
- W4322619881 cites W1987437644 @default.
- W4322619881 cites W1989433476 @default.
- W4322619881 cites W1990337343 @default.
- W4322619881 cites W1993402059 @default.
- W4322619881 cites W1995365389 @default.
- W4322619881 cites W2002117545 @default.
- W4322619881 cites W2006189460 @default.
- W4322619881 cites W2012223636 @default.
- W4322619881 cites W2015359315 @default.
- W4322619881 cites W2021469232 @default.
- W4322619881 cites W2023949937 @default.
- W4322619881 cites W2027651093 @default.
- W4322619881 cites W2028576131 @default.
- W4322619881 cites W2033889320 @default.
- W4322619881 cites W2035671523 @default.
- W4322619881 cites W2037787472 @default.
- W4322619881 cites W2038199718 @default.
- W4322619881 cites W2039021768 @default.
- W4322619881 cites W2045402087 @default.
- W4322619881 cites W2048249034 @default.
- W4322619881 cites W2048280438 @default.
- W4322619881 cites W2049253479 @default.
- W4322619881 cites W2049374415 @default.
- W4322619881 cites W2049594822 @default.
- W4322619881 cites W2056344220 @default.
- W4322619881 cites W2057066298 @default.
- W4322619881 cites W2059179399 @default.
- W4322619881 cites W2078933682 @default.
- W4322619881 cites W2079843936 @default.
- W4322619881 cites W2085253664 @default.
- W4322619881 cites W2086948789 @default.
- W4322619881 cites W2089244020 @default.
- W4322619881 cites W2090485158 @default.
- W4322619881 cites W2093028936 @default.
- W4322619881 cites W2099817260 @default.
- W4322619881 cites W2102145001 @default.
- W4322619881 cites W2103017472 @default.
- W4322619881 cites W2103573390 @default.
- W4322619881 cites W2105707485 @default.
- W4322619881 cites W2111098663 @default.
- W4322619881 cites W2111677023 @default.
- W4322619881 cites W2120016245 @default.
- W4322619881 cites W2120171716 @default.
- W4322619881 cites W2121103946 @default.
- W4322619881 cites W2121169682 @default.
- W4322619881 cites W2121262235 @default.
- W4322619881 cites W2125574061 @default.
- W4322619881 cites W2130434635 @default.
- W4322619881 cites W2140946052 @default.
- W4322619881 cites W2145480416 @default.
- W4322619881 cites W2148490163 @default.
- W4322619881 cites W2148801773 @default.
- W4322619881 cites W2148810272 @default.
- W4322619881 cites W2159330532 @default.
- W4322619881 cites W2168434032 @default.
- W4322619881 cites W2170177782 @default.
- W4322619881 cites W2170776626 @default.
- W4322619881 cites W2172231976 @default.
- W4322619881 cites W2181409166 @default.
- W4322619881 cites W2278988761 @default.
- W4322619881 cites W2302020441 @default.
- W4322619881 cites W2304846645 @default.
- W4322619881 cites W2312292507 @default.
- W4322619881 cites W2312990705 @default.
- W4322619881 cites W2317082846 @default.
- W4322619881 cites W2327951898 @default.
- W4322619881 cites W2343251287 @default.
- W4322619881 cites W2346277556 @default.
- W4322619881 cites W2404856950 @default.
- W4322619881 cites W2411269790 @default.
- W4322619881 cites W2604738787 @default.
- W4322619881 cites W2604924504 @default.
- W4322619881 cites W2605804656 @default.
- W4322619881 cites W2606932135 @default.
- W4322619881 cites W2607253842 @default.
- W4322619881 cites W2611451206 @default.
- W4322619881 cites W2637236839 @default.
- W4322619881 cites W2674118028 @default.
- W4322619881 cites W2750671143 @default.
- W4322619881 cites W2762504941 @default.