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- W4322622919 abstract "Precisely organizing functional molecules of the catalytic cores in natural enzymes to promote catalytic performance is a challenging goal in respect to artificial enzyme construction. In this work, we report a DNA-scaffolded mimicry of the catalytic cores of hydrolases, which showed a controllable and hierarchical acceleration of the hydrolysis of fluorescein diacetate (FDA). The results revealed that the efficiency of hydrolysis was greatly increased by the DNA-scaffold-induced proximity of catalytic amino acid residues (histidine and arginine) with up to 4-fold improvement relative to the free amino acids. In addition, DNA-scaffolded one-dimensional and two-dimensional assemblies of multiple catalytic cores could further accelerate the hydrolysis. This work demonstrated that the DNA-guided assembly could be used as a promising platform to build enzyme mimics in a programmable and hierarchical way." @default.
- W4322622919 created "2023-03-01" @default.
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- W4322622919 date "2023-02-28" @default.
- W4322622919 modified "2023-10-09" @default.
- W4322622919 title "Controlled Self-Assembly of the Catalytic Core of Hydrolases Using DNA Scaffolds" @default.
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- W4322622919 doi "https://doi.org/10.1021/acs.nanolett.2c03387" @default.
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