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- W4322623147 abstract "Abstract Markers predicting response and resistance to chimeric antigen receptor (CAR) T cells in relapsed/refractory multiple myeloma are currently missing. We subjected cells isolated from peripheral blood and bone marrow before and after the application of CAR T cells directed against B cell maturation antigen to single cell multi-omic analyses to identify markers associated with resistance and early relapse. Differences between responders and non-responders were already identified at time of leukapheresis. Non-responders showed an immunosuppressive microenvironment characterized by increased numbers of monocytes expressing the immune checkpoint molecule CD39 and suppressing CD8+ and NK cell function. The analyses of CAR T cells showed cytotoxic and exhausted phenotypes in hyperexpanded compared to low/intermediate expanded clones. We identified potential immunotherapeutic targets on CAR T cells, like PD1 and KLRB1, to improve their functionality and durability. Our work provides first evidence that an immunosuppressive microenvironment is associated with resistance to CAR T cell therapies." @default.
- W4322623147 created "2023-03-01" @default.
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- W4322623147 date "2023-02-28" @default.
- W4322623147 modified "2023-09-27" @default.
- W4322623147 title "Single cell multi-omic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma" @default.
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- W4322623147 doi "https://doi.org/10.21203/rs.3.rs-2626343/v1" @default.
- W4322623147 hasPublicationYear "2023" @default.
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