Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322625424> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4322625424 endingPage "1452" @default.
- W4322625424 startingPage "1452" @default.
- W4322625424 abstract "<ns4:p><ns4:bold>Background:</ns4:bold> Medicinal plants have been demonstrated to possess various pharmacological effects including anti-hepatitis C virus. Acacia mangium is one of the Acacia genus that contain with various metabolites. The metaboilites play an important role for antiviral activities. The current study examined the anti-hepatitis C virus (HCV) activities of <ns4:italic>Acacia mangium</ns4:italic> extracts in solvents with various polarities and further evaluated the mechanism of action of the extracts on the protein virus and combination treatment models.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> Anti-hepatitis C virus activities was conducted by <ns4:italic>in vitro</ns4:italic> culture cells of Huh 7it both in a single or combination treatment. Further examined its NS3 protein inhibition was evaluated by western blotting assay.</ns4:p><ns4:p> <ns4:bold>Results:</ns4:bold> The results revealed the strong anti-HCV activities of the extracts. The 50% inhibition concentrations (IC<ns4:sub>50</ns4:sub>s) of the ethanol, n-hexane, dichloromethane and methanol extracts were of 4.6 ± 0.3, 2.9 ± 0.2, 0.2 ± 0.3, and 2.8 ± 0.2 μg/mL, respectively, and no cytotoxic effect was detected. These extracts displayed stronger effects than the positive control ribavirin. The mode of action of the ethanol extract was evaluated at 30 µg/mL, revealing that the inhibitory effect was stronger on the post-entry step than on the entry step. Western blotting revealed that the extracts decreased NS3 protein expression, indicating that virus replication was suppressed. Further evaluation illustrated that combined treatment with the ethanol extract enhanced the anti-viral activity of simeprevir.</ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> These results indicated that <ns4:italic>A. mangium</ns4:italic> leaves could represent sources of anti-HCV agents.</ns4:p>" @default.
- W4322625424 created "2023-03-01" @default.
- W4322625424 creator A5001709132 @default.
- W4322625424 creator A5011778747 @default.
- W4322625424 creator A5019193545 @default.
- W4322625424 creator A5025845504 @default.
- W4322625424 creator A5084435286 @default.
- W4322625424 creator A5078822057 @default.
- W4322625424 date "2023-02-28" @default.
- W4322625424 modified "2023-09-26" @default.
- W4322625424 title "Acacia mangium: A promising plant for isolating anti-hepatitis C virus agents" @default.
- W4322625424 cites W1173053129 @default.
- W4322625424 cites W1960714685 @default.
- W4322625424 cites W1966153332 @default.
- W4322625424 cites W1975576681 @default.
- W4322625424 cites W2001852099 @default.
- W4322625424 cites W2004817638 @default.
- W4322625424 cites W2022621558 @default.
- W4322625424 cites W2026878864 @default.
- W4322625424 cites W2043141710 @default.
- W4322625424 cites W2049495631 @default.
- W4322625424 cites W2051409620 @default.
- W4322625424 cites W2084042049 @default.
- W4322625424 cites W2097084266 @default.
- W4322625424 cites W2104699997 @default.
- W4322625424 cites W2118542945 @default.
- W4322625424 cites W2120490290 @default.
- W4322625424 cites W2130771841 @default.
- W4322625424 cites W2138488044 @default.
- W4322625424 cites W2146882976 @default.
- W4322625424 cites W2149549646 @default.
- W4322625424 cites W2169891043 @default.
- W4322625424 cites W2185218296 @default.
- W4322625424 cites W2652714981 @default.
- W4322625424 cites W2913849859 @default.
- W4322625424 cites W2995013214 @default.
- W4322625424 cites W3120061830 @default.
- W4322625424 cites W3189283617 @default.
- W4322625424 cites W3207200842 @default.
- W4322625424 cites W4307939599 @default.
- W4322625424 doi "https://doi.org/10.12688/f1000research.124947.2" @default.
- W4322625424 hasPublicationYear "2023" @default.
- W4322625424 type Work @default.
- W4322625424 citedByCount "0" @default.
- W4322625424 crossrefType "journal-article" @default.
- W4322625424 hasAuthorship W4322625424A5001709132 @default.
- W4322625424 hasAuthorship W4322625424A5011778747 @default.
- W4322625424 hasAuthorship W4322625424A5019193545 @default.
- W4322625424 hasAuthorship W4322625424A5025845504 @default.
- W4322625424 hasAuthorship W4322625424A5078822057 @default.
- W4322625424 hasAuthorship W4322625424A5084435286 @default.
- W4322625424 hasBestOaLocation W43226254241 @default.
- W4322625424 hasConcept C132379496 @default.
- W4322625424 hasConcept C159047783 @default.
- W4322625424 hasConcept C2522874641 @default.
- W4322625424 hasConcept C2776408679 @default.
- W4322625424 hasConcept C2779854691 @default.
- W4322625424 hasConcept C55493867 @default.
- W4322625424 hasConcept C556039675 @default.
- W4322625424 hasConcept C71924100 @default.
- W4322625424 hasConcept C86803240 @default.
- W4322625424 hasConceptScore W4322625424C132379496 @default.
- W4322625424 hasConceptScore W4322625424C159047783 @default.
- W4322625424 hasConceptScore W4322625424C2522874641 @default.
- W4322625424 hasConceptScore W4322625424C2776408679 @default.
- W4322625424 hasConceptScore W4322625424C2779854691 @default.
- W4322625424 hasConceptScore W4322625424C55493867 @default.
- W4322625424 hasConceptScore W4322625424C556039675 @default.
- W4322625424 hasConceptScore W4322625424C71924100 @default.
- W4322625424 hasConceptScore W4322625424C86803240 @default.
- W4322625424 hasLocation W43226254241 @default.
- W4322625424 hasOpenAccess W4322625424 @default.
- W4322625424 hasPrimaryLocation W43226254241 @default.
- W4322625424 hasRelatedWork W1996544810 @default.
- W4322625424 hasRelatedWork W2016551366 @default.
- W4322625424 hasRelatedWork W2056772893 @default.
- W4322625424 hasRelatedWork W2088796437 @default.
- W4322625424 hasRelatedWork W2123163123 @default.
- W4322625424 hasRelatedWork W2138564085 @default.
- W4322625424 hasRelatedWork W2142062823 @default.
- W4322625424 hasRelatedWork W2188759708 @default.
- W4322625424 hasRelatedWork W2400613564 @default.
- W4322625424 hasRelatedWork W2556776743 @default.
- W4322625424 hasVolume "11" @default.
- W4322625424 isParatext "false" @default.
- W4322625424 isRetracted "false" @default.
- W4322625424 workType "article" @default.