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- W4322625512 endingPage "100522" @default.
- W4322625512 startingPage "100522" @default.
- W4322625512 abstract "PKC epsilon (PKCε) plays important roles in behavioral responses to alcohol and in anxiety-like behavior in rodents, making it a potential drug target for reducing alcohol consumption and anxiety. Identifying signals downstream of PKCε could reveal additional targets and strategies for interfering with PKCε signaling. We used a chemical genetic screen combined with mass spectrometry to identify direct substrates of PKCε in mouse brain and validated findings for 39 of them using peptide arrays and in vitro kinase assays. Prioritizing substrates with several public databases such as LINCS-L1000, STRING, GeneFriends, and GeneMAINA predicted interactions between these putative substrates and PKCε and identified substrates associated with alcohol-related behaviors, actions of benzodiazepines, and chronic stress. The 39 substrates could be broadly classified in three functional categories: cytoskeletal regulation, morphogenesis, and synaptic function. These results provide a list of brain PKCε substrates, many of which are novel, for future investigation to determine the role of PKCε signaling in alcohol responses, anxiety, responses to stress, and other related behaviors." @default.
- W4322625512 created "2023-03-01" @default.
- W4322625512 creator A5007608050 @default.
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- W4322625512 creator A5082573171 @default.
- W4322625512 date "2023-04-01" @default.
- W4322625512 modified "2023-10-18" @default.
- W4322625512 title "Chemical Genetic Identification of PKC Epsilon Substrates in Mouse Brain" @default.
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