Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322628474> ?p ?o ?g. }
- W4322628474 endingPage "477" @default.
- W4322628474 startingPage "477" @default.
- W4322628474 abstract "Literature is scarce regarding volumetric measures of limbic system components across the pediatric age range. The purpose of this study is to remedy this scarcity by reporting continuous volumetric measurements of limbic system components, and to provide consistent stratification data including age-related trajectories and sex-related differences in the pediatric age range in order to improve the recognition of structural variations that might reflect pathology.In this retrospective study, MRI sequences of children with normal clinical MRI examinations of the brain acquired between January 2010 and December 2019 were included. Isotropic 3D T1-weighted were processed using FreeSurfer version 7.3. Total brain volume and volumes of the limbic system including the hippocampus, parahippocampal gyrus, amygdala, hypothalamus, cingulate gyrus, entorhinal cortex, anteroventral thalamic nucleus, and whole thalamus were assessed. Parcellated output was displayed with the respective label map overlay and images were visually inspected for accuracy of regional segmentation results. Continuous data are provided as mean and standard deviation with quadratic trendlines and as mean and 95% confidence intervals. Categorical data are presented as integers and percentages (%).A total of 724 children (401 female, 55.4%), with a mean age at time of MRI of 10.9 ± 4.2 years (range: 1.9-18.2 years), were included in the study. For females, the total brain volume increased from 955 ± 70 mL at the age of 2-3 years to 1140 ± 110 mL at the age of 17-18 years. Similarly, the total brain volume increased for males from 1004 ± 83 mL to 1263 ± 96 mL. The maximum volume was noted at 11-12 years for females (1188 ± 90 mL) and at 14-15 years for males (1310 ± 159 mL). Limbic system structures reached their peak volume more commonly between the 13-14 years to 17-18 years age groups. The male cingulate gyrus, entorhinal cortex, and anteroventral thalamic nucleus reached peak volume before or at 9-10 years.This study provides unique age- and sex-specific volumes of the components of the limbic system throughout the pediatric age range to serve as normal values in comparative studies. Quantification of volumetric abnormalities of the limbic system on brain MRI may offer insights into phenotypical variations of diseases and may help elucidate new pathological phenotypes." @default.
- W4322628474 created "2023-03-01" @default.
- W4322628474 creator A5057212936 @default.
- W4322628474 creator A5060185258 @default.
- W4322628474 creator A5066085902 @default.
- W4322628474 creator A5082839686 @default.
- W4322628474 date "2023-02-27" @default.
- W4322628474 modified "2023-09-26" @default.
- W4322628474 title "MRI Volumetric Analysis of the Hypothalamus and Limbic System across the Pediatric Age Span" @default.
- W4322628474 cites W13231903 @default.
- W4322628474 cites W1966745801 @default.
- W4322628474 cites W1968677514 @default.
- W4322628474 cites W1977884901 @default.
- W4322628474 cites W2002689596 @default.
- W4322628474 cites W2004293194 @default.
- W4322628474 cites W2007581301 @default.
- W4322628474 cites W2009779345 @default.
- W4322628474 cites W2019299015 @default.
- W4322628474 cites W2034336478 @default.
- W4322628474 cites W2040759402 @default.
- W4322628474 cites W2058770289 @default.
- W4322628474 cites W2084407809 @default.
- W4322628474 cites W2084443965 @default.
- W4322628474 cites W2093640020 @default.
- W4322628474 cites W2097986645 @default.
- W4322628474 cites W2101135654 @default.
- W4322628474 cites W2113319997 @default.
- W4322628474 cites W2121369614 @default.
- W4322628474 cites W2129110660 @default.
- W4322628474 cites W2133054185 @default.
- W4322628474 cites W2141693417 @default.
- W4322628474 cites W2142250660 @default.
- W4322628474 cites W2145103486 @default.
- W4322628474 cites W2151721316 @default.
- W4322628474 cites W2157064920 @default.
- W4322628474 cites W2482609177 @default.
- W4322628474 cites W2611096323 @default.
- W4322628474 cites W2737094118 @default.
- W4322628474 cites W2963410151 @default.
- W4322628474 cites W3028368183 @default.
- W4322628474 cites W3034761030 @default.
- W4322628474 cites W3080123676 @default.
- W4322628474 cites W3154548510 @default.
- W4322628474 cites W3204731862 @default.
- W4322628474 cites W3210282555 @default.
- W4322628474 cites W4225246927 @default.
- W4322628474 cites W4241074797 @default.
- W4322628474 cites W4280647176 @default.
- W4322628474 cites W4284892930 @default.
- W4322628474 cites W4285077009 @default.
- W4322628474 cites W4285384439 @default.
- W4322628474 cites W4291972192 @default.
- W4322628474 cites W4296224130 @default.
- W4322628474 cites W4296608980 @default.
- W4322628474 cites W4309271246 @default.
- W4322628474 doi "https://doi.org/10.3390/children10030477" @default.
- W4322628474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36980035" @default.
- W4322628474 hasPublicationYear "2023" @default.
- W4322628474 type Work @default.
- W4322628474 citedByCount "0" @default.
- W4322628474 crossrefType "journal-article" @default.
- W4322628474 hasAuthorship W4322628474A5057212936 @default.
- W4322628474 hasAuthorship W4322628474A5060185258 @default.
- W4322628474 hasAuthorship W4322628474A5066085902 @default.
- W4322628474 hasAuthorship W4322628474A5082839686 @default.
- W4322628474 hasBestOaLocation W43226284741 @default.
- W4322628474 hasConcept C126322002 @default.
- W4322628474 hasConcept C126838900 @default.
- W4322628474 hasConcept C143409427 @default.
- W4322628474 hasConcept C15744967 @default.
- W4322628474 hasConcept C169760540 @default.
- W4322628474 hasConcept C2778013878 @default.
- W4322628474 hasConcept C2778048536 @default.
- W4322628474 hasConcept C2778186239 @default.
- W4322628474 hasConcept C2779144063 @default.
- W4322628474 hasConcept C2779246727 @default.
- W4322628474 hasConcept C2779369059 @default.
- W4322628474 hasConcept C2780715579 @default.
- W4322628474 hasConcept C2781099131 @default.
- W4322628474 hasConcept C2781161787 @default.
- W4322628474 hasConcept C2781192897 @default.
- W4322628474 hasConcept C529278444 @default.
- W4322628474 hasConcept C541082541 @default.
- W4322628474 hasConcept C65835030 @default.
- W4322628474 hasConcept C71924100 @default.
- W4322628474 hasConceptScore W4322628474C126322002 @default.
- W4322628474 hasConceptScore W4322628474C126838900 @default.
- W4322628474 hasConceptScore W4322628474C143409427 @default.
- W4322628474 hasConceptScore W4322628474C15744967 @default.
- W4322628474 hasConceptScore W4322628474C169760540 @default.
- W4322628474 hasConceptScore W4322628474C2778013878 @default.
- W4322628474 hasConceptScore W4322628474C2778048536 @default.
- W4322628474 hasConceptScore W4322628474C2778186239 @default.
- W4322628474 hasConceptScore W4322628474C2779144063 @default.
- W4322628474 hasConceptScore W4322628474C2779246727 @default.
- W4322628474 hasConceptScore W4322628474C2779369059 @default.
- W4322628474 hasConceptScore W4322628474C2780715579 @default.
- W4322628474 hasConceptScore W4322628474C2781099131 @default.