Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322631805> ?p ?o ?g. }
- W4322631805 endingPage "1537" @default.
- W4322631805 startingPage "1537" @default.
- W4322631805 abstract "Malignant pleural mesothelioma (MPM) is an aggressive thoracic cancer that is mainly associated with prior exposure to asbestos fibers. Despite being a rare cancer, its global rate is increasing and the prognosis remains extremely poor. Over the last two decades, despite the constant research of new therapeutic options, the combination chemotherapy with cisplatin and pemetrexed has remained the only first-line therapy for MPM. The recent approval of immune checkpoint blockade (ICB)-based immunotherapy has opened new promising avenues of research. However, MPM is still a fatal cancer with no effective treatments. Enhancer of zeste homolog 2 (EZH2) is a histone methyl transferase that exerts pro-oncogenic and immunomodulatory activities in a variety of tumors. Accordingly, a growing number of studies indicate that EZH2 is also an oncogenic driver in MPM, but its effects on tumor microenvironments are still largely unexplored. This review describes the state-of-the-art of EZH2 in MPM biology and discusses its potential use both as a diagnostic and therapeutic target. We highlight current gaps of knowledge, the filling of which will likely favor the entry of EZH2 inhibitors within the treatment options for MPM patients." @default.
- W4322631805 created "2023-03-01" @default.
- W4322631805 creator A5019310092 @default.
- W4322631805 creator A5027311900 @default.
- W4322631805 creator A5035167543 @default.
- W4322631805 creator A5085799356 @default.
- W4322631805 date "2023-02-28" @default.
- W4322631805 modified "2023-09-26" @default.
- W4322631805 title "Benefits and Challenges of Inhibiting EZH2 in Malignant Pleural Mesothelioma" @default.
- W4322631805 cites W1538763181 @default.
- W4322631805 cites W1827919153 @default.
- W4322631805 cites W1982067611 @default.
- W4322631805 cites W1985690846 @default.
- W4322631805 cites W1986659029 @default.
- W4322631805 cites W1988400501 @default.
- W4322631805 cites W1991863108 @default.
- W4322631805 cites W2004432761 @default.
- W4322631805 cites W2007265317 @default.
- W4322631805 cites W2011088911 @default.
- W4322631805 cites W2016343650 @default.
- W4322631805 cites W2017492512 @default.
- W4322631805 cites W2034042626 @default.
- W4322631805 cites W2042959792 @default.
- W4322631805 cites W2057065967 @default.
- W4322631805 cites W2074699765 @default.
- W4322631805 cites W2083654253 @default.
- W4322631805 cites W2100630390 @default.
- W4322631805 cites W2102627969 @default.
- W4322631805 cites W2103021272 @default.
- W4322631805 cites W2113035823 @default.
- W4322631805 cites W2124505866 @default.
- W4322631805 cites W2130085343 @default.
- W4322631805 cites W2132310381 @default.
- W4322631805 cites W2140590116 @default.
- W4322631805 cites W2142607055 @default.
- W4322631805 cites W2157316821 @default.
- W4322631805 cites W2199397492 @default.
- W4322631805 cites W2215044613 @default.
- W4322631805 cites W2230894635 @default.
- W4322631805 cites W2274387391 @default.
- W4322631805 cites W2291531085 @default.
- W4322631805 cites W2291537115 @default.
- W4322631805 cites W2320983896 @default.
- W4322631805 cites W2324509048 @default.
- W4322631805 cites W2461824643 @default.
- W4322631805 cites W2473077661 @default.
- W4322631805 cites W2512573865 @default.
- W4322631805 cites W2520974189 @default.
- W4322631805 cites W2538189337 @default.
- W4322631805 cites W2553388903 @default.
- W4322631805 cites W2558414061 @default.
- W4322631805 cites W2586367025 @default.
- W4322631805 cites W2698245864 @default.
- W4322631805 cites W2737220388 @default.
- W4322631805 cites W2748527944 @default.
- W4322631805 cites W2751044391 @default.
- W4322631805 cites W2754312097 @default.
- W4322631805 cites W2767175100 @default.
- W4322631805 cites W2769376917 @default.
- W4322631805 cites W2783083929 @default.
- W4322631805 cites W2791898765 @default.
- W4322631805 cites W2793237841 @default.
- W4322631805 cites W2794473240 @default.
- W4322631805 cites W2794718095 @default.
- W4322631805 cites W2794825632 @default.
- W4322631805 cites W2795441802 @default.
- W4322631805 cites W2795557894 @default.
- W4322631805 cites W2808497725 @default.
- W4322631805 cites W2811134526 @default.
- W4322631805 cites W2888230996 @default.
- W4322631805 cites W2892042921 @default.
- W4322631805 cites W2897299514 @default.
- W4322631805 cites W2902678397 @default.
- W4322631805 cites W2911341716 @default.
- W4322631805 cites W2912552280 @default.
- W4322631805 cites W2918094089 @default.
- W4322631805 cites W2920068846 @default.
- W4322631805 cites W2924341172 @default.
- W4322631805 cites W2941053886 @default.
- W4322631805 cites W2941221744 @default.
- W4322631805 cites W2943931049 @default.
- W4322631805 cites W2970548174 @default.
- W4322631805 cites W2970734757 @default.
- W4322631805 cites W2973266161 @default.
- W4322631805 cites W2976577691 @default.
- W4322631805 cites W2983752863 @default.
- W4322631805 cites W2986062566 @default.
- W4322631805 cites W2995917664 @default.
- W4322631805 cites W3002750475 @default.
- W4322631805 cites W3005469082 @default.
- W4322631805 cites W3011290602 @default.
- W4322631805 cites W3018674756 @default.
- W4322631805 cites W3021608864 @default.
- W4322631805 cites W3028339529 @default.
- W4322631805 cites W3034278654 @default.
- W4322631805 cites W3037243834 @default.
- W4322631805 cites W3039614857 @default.
- W4322631805 cites W3045753156 @default.