Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322701732> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4322701732 endingPage "1808" @default.
- W4322701732 startingPage "1804" @default.
- W4322701732 abstract "BACKGROUND Adenocarcinomas and carcinoid tumors are the most common malignant tumors of the small intestine. K-ras oncogene mutations at codon 12 are common in gastric, pancreatic, and colon carcinomas, with an incidence of 35-88%. K-ras mutations have not been extensively studied in either adenocarcinomas or carcinoid tumors of the small bowel. The purpose of this study was to determine whether ras mutations play an important role in the formation of these tumors. METHODS Archival tissues from 28 adenocarcinomas and 22 carcinoid tumors of the small bowel were studied, along with archival tissues from 32 adenocarcinomas of the large bowel, which were used as controls. DNA from the small intestine tumors was analyzed for K-ras, H-ras, and N-ras oncogene mutations at codons 12, 13, and 61, using polymerase chain reaction and sequence specific oligonucleotide hybridization techniques. Large bowel adenocarcinomas were analyzed for K-ras mutations at codons 12 and 13. RESULTS A point mutation of K-ras at codon 12 was detected in 4 of 28 (14.3%) of the small bowel adenocarcinomas, in 12 of 32 (37.5%) of the large bowel adenocarcinomas, and in 0 of 22 small intestine carcinoid tumors. No other K-ras, H-ras, or N-ras mutations were detected in any of the small bowel tumors. Each small intestine K-ras mutation was found in a duodenal adenocarcinoma (4 of 12 cases, 33%), whereas none occurred in 16 other jejunal or ileal adenocarcinomas. CONCLUSIONS K-ras mutations appear to play a significant role in the pathogenesis of duodenal adenocarcinomas, but they do not appear to be important in the development of jejunal or ileal adenocarcinomas or of carcinoid tumors of the small intestine. Cancer 1997; 79:1804-8. © 1997 American Cancer Society." @default.
- W4322701732 created "2023-03-02" @default.
- W4322701732 creator A5012182559 @default.
- W4322701732 creator A5012975808 @default.
- W4322701732 creator A5018461350 @default.
- W4322701732 creator A5026242562 @default.
- W4322701732 creator A5047802881 @default.
- W4322701732 creator A5087296692 @default.
- W4322701732 date "1997-05-01" @default.
- W4322701732 modified "2023-10-10" @default.
- W4322701732 title "The presence of K-12ras mutations in duodenal adenocarcinomas and the absence ofras mutations in other small bowel adenocarcinomas and carcinoid tumors" @default.
- W4322701732 cites W1973800266 @default.
- W4322701732 cites W1980847511 @default.
- W4322701732 cites W2001258296 @default.
- W4322701732 cites W2004945048 @default.
- W4322701732 cites W2005664971 @default.
- W4322701732 cites W2049509335 @default.
- W4322701732 cites W2053265230 @default.
- W4322701732 cites W2058649415 @default.
- W4322701732 cites W2061106767 @default.
- W4322701732 cites W2063361805 @default.
- W4322701732 cites W2063862702 @default.
- W4322701732 cites W2065349468 @default.
- W4322701732 cites W2071697240 @default.
- W4322701732 cites W2073336864 @default.
- W4322701732 cites W2091723114 @default.
- W4322701732 cites W2091976105 @default.
- W4322701732 cites W2094565618 @default.
- W4322701732 cites W2127218675 @default.
- W4322701732 cites W2170585471 @default.
- W4322701732 cites W2313978670 @default.
- W4322701732 cites W2320138981 @default.
- W4322701732 doi "https://doi.org/10.1002/(sici)1097-0142(19970501)79:9<1804::aid-cncr24>3.0.co;2-0" @default.
- W4322701732 hasPublicationYear "1997" @default.
- W4322701732 type Work @default.
- W4322701732 citedByCount "44" @default.
- W4322701732 countsByYear W43227017322012 @default.
- W4322701732 countsByYear W43227017322013 @default.
- W4322701732 countsByYear W43227017322015 @default.
- W4322701732 countsByYear W43227017322016 @default.
- W4322701732 countsByYear W43227017322018 @default.
- W4322701732 countsByYear W43227017322021 @default.
- W4322701732 crossrefType "journal-article" @default.
- W4322701732 hasAuthorship W4322701732A5012182559 @default.
- W4322701732 hasAuthorship W4322701732A5012975808 @default.
- W4322701732 hasAuthorship W4322701732A5018461350 @default.
- W4322701732 hasAuthorship W4322701732A5026242562 @default.
- W4322701732 hasAuthorship W4322701732A5047802881 @default.
- W4322701732 hasAuthorship W4322701732A5087296692 @default.
- W4322701732 hasConcept C104317684 @default.
- W4322701732 hasConcept C121608353 @default.
- W4322701732 hasConcept C126322002 @default.
- W4322701732 hasConcept C142724271 @default.
- W4322701732 hasConcept C176944494 @default.
- W4322701732 hasConcept C2777882243 @default.
- W4322701732 hasConcept C2778506435 @default.
- W4322701732 hasConcept C2781182431 @default.
- W4322701732 hasConcept C2908862229 @default.
- W4322701732 hasConcept C501734568 @default.
- W4322701732 hasConcept C502942594 @default.
- W4322701732 hasConcept C54355233 @default.
- W4322701732 hasConcept C71924100 @default.
- W4322701732 hasConcept C86803240 @default.
- W4322701732 hasConcept C90924648 @default.
- W4322701732 hasConceptScore W4322701732C104317684 @default.
- W4322701732 hasConceptScore W4322701732C121608353 @default.
- W4322701732 hasConceptScore W4322701732C126322002 @default.
- W4322701732 hasConceptScore W4322701732C142724271 @default.
- W4322701732 hasConceptScore W4322701732C176944494 @default.
- W4322701732 hasConceptScore W4322701732C2777882243 @default.
- W4322701732 hasConceptScore W4322701732C2778506435 @default.
- W4322701732 hasConceptScore W4322701732C2781182431 @default.
- W4322701732 hasConceptScore W4322701732C2908862229 @default.
- W4322701732 hasConceptScore W4322701732C501734568 @default.
- W4322701732 hasConceptScore W4322701732C502942594 @default.
- W4322701732 hasConceptScore W4322701732C54355233 @default.
- W4322701732 hasConceptScore W4322701732C71924100 @default.
- W4322701732 hasConceptScore W4322701732C86803240 @default.
- W4322701732 hasConceptScore W4322701732C90924648 @default.
- W4322701732 hasIssue "9" @default.
- W4322701732 hasLocation W43227017321 @default.
- W4322701732 hasOpenAccess W4322701732 @default.
- W4322701732 hasPrimaryLocation W43227017321 @default.
- W4322701732 hasRelatedWork W1480986388 @default.
- W4322701732 hasRelatedWork W1984842630 @default.
- W4322701732 hasRelatedWork W2029130896 @default.
- W4322701732 hasRelatedWork W2040015620 @default.
- W4322701732 hasRelatedWork W2060452880 @default.
- W4322701732 hasRelatedWork W2124687734 @default.
- W4322701732 hasRelatedWork W22414651 @default.
- W4322701732 hasRelatedWork W2345941100 @default.
- W4322701732 hasRelatedWork W2985303393 @default.
- W4322701732 hasRelatedWork W314682845 @default.
- W4322701732 hasVolume "79" @default.
- W4322701732 isParatext "false" @default.
- W4322701732 isRetracted "false" @default.
- W4322701732 workType "article" @default.