Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322702927> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4322702927 endingPage "7649" @default.
- W4322702927 startingPage "7639" @default.
- W4322702927 abstract "The dendritic and axonal arbors of developing retinal ganglion cells (RGCs) are exposed to two sources of BDNF: RGC dendrites are exposed to BDNF locally within the retina, and RGC axons are exposed to BDNF at the target, the optic tectum. Our previous studies demonstrated that increasing tectal BDNF levels promotes RGC axon terminal arborization, whereas increasing retinal BDNF levels inhibits RGC dendritic arborization. These results suggested that differential neurotrophic action at the axon versus dendrite might be responsible for the opposing effects of BDNF on RGC axonal versus dendritic arborization. To explore this possibility, we examined the effects of altering BDNF levels at the optic tectum on the elaboration of RGC dendritic arbors in the retina. Increasing tectal BDNF levels resulted in a significant increase in dendritic branching, whereas neutralizing endogenous tectal BDNF with function-blocking antibodies significantly decreased dendritic arbor complexity. Thus, RGC dendritic arbors react in opposing manners to retinal- versus tectal-derived BDNF. Alterations in retinal BDNF levels, however, did not affect axon terminal arborization. Thus, RGC dendritic arborization is controlled in a complementary manner by both local and target-derived sources of BDNF, whereas axon arborization is modulated solely by neurotrophic interactions at the target. Together, our results indicate that developing RGCs modulate dendritic arborization by integrating signals from discrete sources of BDNF in the eye and brain. Differential integration of spatially discrete neurotrophin signals within a single neuron may therefore finely tune afferent and efferent neuronal connectivity." @default.
- W4322702927 created "2023-03-02" @default.
- W4322702927 creator A5004446950 @default.
- W4322702927 creator A5042113667 @default.
- W4322702927 creator A5045570280 @default.
- W4322702927 creator A5056497976 @default.
- W4322702927 creator A5071221295 @default.
- W4322702927 date "2002-09-01" @default.
- W4322702927 modified "2023-10-16" @default.
- W4322702927 title "Local and Target-Derived Brain-Derived Neurotrophic Factor Exert Opposing Effects on the Dendritic Arborization of Retinal Ganglion Cells<i>In Vivo</i>" @default.
- W4322702927 doi "https://doi.org/10.1523/jneurosci.22-17-07639.2002" @default.
- W4322702927 hasPublicationYear "2002" @default.
- W4322702927 type Work @default.
- W4322702927 citedByCount "79" @default.
- W4322702927 countsByYear W43227029272012 @default.
- W4322702927 countsByYear W43227029272013 @default.
- W4322702927 countsByYear W43227029272014 @default.
- W4322702927 countsByYear W43227029272015 @default.
- W4322702927 countsByYear W43227029272016 @default.
- W4322702927 countsByYear W43227029272017 @default.
- W4322702927 countsByYear W43227029272019 @default.
- W4322702927 countsByYear W43227029272020 @default.
- W4322702927 countsByYear W43227029272021 @default.
- W4322702927 countsByYear W43227029272022 @default.
- W4322702927 countsByYear W43227029272023 @default.
- W4322702927 crossrefType "journal-article" @default.
- W4322702927 hasAuthorship W4322702927A5004446950 @default.
- W4322702927 hasAuthorship W4322702927A5042113667 @default.
- W4322702927 hasAuthorship W4322702927A5045570280 @default.
- W4322702927 hasAuthorship W4322702927A5056497976 @default.
- W4322702927 hasAuthorship W4322702927A5071221295 @default.
- W4322702927 hasBestOaLocation W43227029271 @default.
- W4322702927 hasConcept C160539049 @default.
- W4322702927 hasConcept C169760540 @default.
- W4322702927 hasConcept C170493617 @default.
- W4322702927 hasConcept C2777093970 @default.
- W4322702927 hasConcept C2777624874 @default.
- W4322702927 hasConcept C2777918570 @default.
- W4322702927 hasConcept C2778790584 @default.
- W4322702927 hasConcept C2779480072 @default.
- W4322702927 hasConcept C2779530196 @default.
- W4322702927 hasConcept C2780827179 @default.
- W4322702927 hasConcept C529278444 @default.
- W4322702927 hasConcept C552161191 @default.
- W4322702927 hasConcept C55493867 @default.
- W4322702927 hasConcept C68710172 @default.
- W4322702927 hasConcept C86803240 @default.
- W4322702927 hasConcept C92020748 @default.
- W4322702927 hasConcept C95444343 @default.
- W4322702927 hasConceptScore W4322702927C160539049 @default.
- W4322702927 hasConceptScore W4322702927C169760540 @default.
- W4322702927 hasConceptScore W4322702927C170493617 @default.
- W4322702927 hasConceptScore W4322702927C2777093970 @default.
- W4322702927 hasConceptScore W4322702927C2777624874 @default.
- W4322702927 hasConceptScore W4322702927C2777918570 @default.
- W4322702927 hasConceptScore W4322702927C2778790584 @default.
- W4322702927 hasConceptScore W4322702927C2779480072 @default.
- W4322702927 hasConceptScore W4322702927C2779530196 @default.
- W4322702927 hasConceptScore W4322702927C2780827179 @default.
- W4322702927 hasConceptScore W4322702927C529278444 @default.
- W4322702927 hasConceptScore W4322702927C552161191 @default.
- W4322702927 hasConceptScore W4322702927C55493867 @default.
- W4322702927 hasConceptScore W4322702927C68710172 @default.
- W4322702927 hasConceptScore W4322702927C86803240 @default.
- W4322702927 hasConceptScore W4322702927C92020748 @default.
- W4322702927 hasConceptScore W4322702927C95444343 @default.
- W4322702927 hasIssue "17" @default.
- W4322702927 hasLocation W43227029271 @default.
- W4322702927 hasLocation W43227029272 @default.
- W4322702927 hasLocation W43227029273 @default.
- W4322702927 hasOpenAccess W4322702927 @default.
- W4322702927 hasPrimaryLocation W43227029271 @default.
- W4322702927 hasRelatedWork W139264979 @default.
- W4322702927 hasRelatedWork W1499212222 @default.
- W4322702927 hasRelatedWork W1578469297 @default.
- W4322702927 hasRelatedWork W1970991806 @default.
- W4322702927 hasRelatedWork W2023142792 @default.
- W4322702927 hasRelatedWork W2025421955 @default.
- W4322702927 hasRelatedWork W2074585853 @default.
- W4322702927 hasRelatedWork W2136511265 @default.
- W4322702927 hasRelatedWork W2196562403 @default.
- W4322702927 hasRelatedWork W2517896435 @default.
- W4322702927 hasVolume "22" @default.
- W4322702927 isParatext "false" @default.
- W4322702927 isRetracted "false" @default.
- W4322702927 workType "article" @default.