FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322709042> ?p ?o ?g. }

• W4322709042 endingPage "45" @default.
• W4322709042 startingPage "39" @default.
• W4322709042 abstract "The effect of a single injection of doxorubicin, 8-day administration of two 5-hydroxypyrimidine derivatives, SNK-411 (2-Isobutyl-4,6-dimethyl-5-hydroxypyrimidine) and SNK-578 (hydrochloride of 2-isobutyl-4,6-dimethyl-5-hydroxypyrimidine), on metastases, lifespan and serum cytokines has been investigated in С57ВL/6 mice after removal of a primary tumor node of Lewis lung carcinoma (LLC). LLC cells (1×106) were injected in the footpad of right hind feet of mice in control and experimental groups; after 14 days of tumor development the hind feet with the tumor were amputated at the ankle level. One hour before the amputation mice received a single injection of doxorubicin (4 mg/kg) and 8-day therapy with the 5-hydroxypyrimidine derivatives started. SNK-578 monotherapy was performed at a dose of 10 mg/kg administered intraperitoneally (i.p.). SNK-411 was administered per os at a dose of 25 mg/kg. In the case of combined therapy mice also received a single injection of doxorubicin (4 mg/kg; i.p.). The metastasis inhibition index in mice-treated with SNK-411 and SNK-578 were 53.3% as compared with control mice (with removed tumor). The mice-treated with SNK-411, doxorubicin, and the combination SNK-578 + doxorubicin had lifespan increased by 60.2%, 53.9%, and 42.9%, respectively. A single injection of doxorubicin, the course administration of the 5-hydroxypyrimidine derivative alone and in combination with single injection of doxorubicin completely decreased serum levels of the prooncogenic Th2-cytokines IL-4, and IL-6 and significantly decreased the level of the Th2-cytokine IL-5. Administration of doxorubicin, SNK-411 and SNK-578 did not influence serum concentration of Th1-cytokine interferon gamma (IFN-γ). These data confirm our previous findings that administration of the compounds studied decreased concentrations of prooncogenic IL-4 and IL-6 in tumor-bearing mice with LLC and had no effect on concentrations of the Th1-cytokine IFN-γ." @default.
• W4322709042 created "2023-03-02" @default.
• W4322709042 creator A5009569965 @default.
• W4322709042 creator A5013229572 @default.
• W4322709042 creator A5032408883 @default.
• W4322709042 creator A5056156940 @default.
• W4322709042 creator A5084880679 @default.
• W4322709042 date "2023-01-01" @default.
• W4322709042 modified "2023-10-16" @default.
• W4322709042 title "Correction of serum prooncogenic cytokines and metastases by 5-hydroxypyrimidine derivatives and doxorubicin after removal of a primary tumor node in mice with the Lewis lung epidermoid carcinoma" @default.
• W4322709042 cites W2006371195 @default.
• W4322709042 cites W2009993815 @default.
• W4322709042 cites W2018895076 @default.
• W4322709042 cites W2099055390 @default.
• W4322709042 cites W2125573114 @default.
• W4322709042 cites W2321191168 @default.
• W4322709042 cites W2509486054 @default.
• W4322709042 cites W2535384004 @default.
• W4322709042 cites W2554618897 @default.
• W4322709042 cites W2605497049 @default.
• W4322709042 cites W2898432308 @default.
• W4322709042 cites W2948631285 @default.
• W4322709042 cites W2964993184 @default.
• W4322709042 cites W2994137058 @default.
• W4322709042 cites W3011450177 @default.
• W4322709042 cites W3036335130 @default.
• W4322709042 cites W3084159535 @default.
• W4322709042 cites W3095780027 @default.
• W4322709042 cites W3118346571 @default.
• W4322709042 cites W3118655301 @default.
• W4322709042 cites W3120928805 @default.
• W4322709042 cites W3154716133 @default.
• W4322709042 doi "https://doi.org/10.18097/pbmc20236901039" @default.
• W4322709042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36857425" @default.
• W4322709042 hasPublicationYear "2023" @default.
• W4322709042 type Work @default.
• W4322709042 citedByCount "0" @default.
• W4322709042 crossrefType "journal-article" @default.
• W4322709042 hasAuthorship W4322709042A5009569965 @default.
• W4322709042 hasAuthorship W4322709042A5013229572 @default.
• W4322709042 hasAuthorship W4322709042A5032408883 @default.
• W4322709042 hasAuthorship W4322709042A5056156940 @default.
• W4322709042 hasAuthorship W4322709042A5084880679 @default.
• W4322709042 hasConcept C121608353 @default.
• W4322709042 hasConcept C126322002 @default.
• W4322709042 hasConcept C185592680 @default.
• W4322709042 hasConcept C2776694085 @default.
• W4322709042 hasConcept C2777847059 @default.
• W4322709042 hasConcept C2779013556 @default.
• W4322709042 hasConcept C2781303535 @default.
• W4322709042 hasConcept C71924100 @default.
• W4322709042 hasConcept C98274493 @default.
• W4322709042 hasConceptScore W4322709042C121608353 @default.
• W4322709042 hasConceptScore W4322709042C126322002 @default.
• W4322709042 hasConceptScore W4322709042C185592680 @default.
• W4322709042 hasConceptScore W4322709042C2776694085 @default.
• W4322709042 hasConceptScore W4322709042C2777847059 @default.
• W4322709042 hasConceptScore W4322709042C2779013556 @default.
• W4322709042 hasConceptScore W4322709042C2781303535 @default.
• W4322709042 hasConceptScore W4322709042C71924100 @default.
• W4322709042 hasConceptScore W4322709042C98274493 @default.
• W4322709042 hasIssue "1" @default.
• W4322709042 hasLocation W43227090421 @default.
• W4322709042 hasLocation W43227090422 @default.
• W4322709042 hasOpenAccess W4322709042 @default.
• W4322709042 hasPrimaryLocation W43227090421 @default.
• W4322709042 hasRelatedWork W2001740086 @default.
• W4322709042 hasRelatedWork W2018180569 @default.
• W4322709042 hasRelatedWork W2088159400 @default.
• W4322709042 hasRelatedWork W2371666691 @default.
• W4322709042 hasRelatedWork W2372387733 @default.
• W4322709042 hasRelatedWork W2378355431 @default.
• W4322709042 hasRelatedWork W2419019593 @default.
• W4322709042 hasRelatedWork W2748952813 @default.
• W4322709042 hasRelatedWork W2899084033 @default.
• W4322709042 hasRelatedWork W2929820477 @default.
• W4322709042 hasVolume "69" @default.
• W4322709042 isParatext "false" @default.
• W4322709042 isRetracted "false" @default.
• W4322709042 workType "article" @default.