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- W4322709871 abstract "Genes implicated in mechanisms that alter the pharmacokinetics of small-molecule therapeutics have historically been the focus of pharmacogenetic research. The FDA allows new protein therapeutics in the market based on pharmacogenetics for clinical applications. It is a time-old knowledge that genetic polymorphisms affect the efficacy and toxicity of an approved drug. The complexity of biological organisms allows protein therapeutics development to proceed cautiously. Methodologies using pharmacogenetic information about the protein therapeutic candidates and their protein receptors can yield successful protein-based drugs. Immunogenicity of protein therapies is becoming a major issue in the development and approval of biologics, indicating that a pharmacogenetic strategy is required. Hence, the hallmarks of therapeutic reactions should be listed and analyzed in order to improve biologics and their success." @default.
- W4322709871 created "2023-03-02" @default.
- W4322709871 creator A5047697724 @default.
- W4322709871 date "2023-01-01" @default.
- W4322709871 modified "2023-10-16" @default.
- W4322709871 title "Pharmacogenetic Biomarkers of Protein Therapeutics" @default.
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- W4322709871 doi "https://doi.org/10.1007/978-981-19-8249-1_8" @default.
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